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1XJO
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STRUCTURE OF AMINOPEPTIDASE
Descriptor:AMINOPEPTIDASE, ZINC ION, PHOSPHATE ION, ...
Authors:Greenblatt, H.M., Barra, D., Blumberg, S., Shoham, G.
Deposit date:1996-10-09
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution.
J.Mol.Biol., 265, 1997
1ARL
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CARBOXYPEPTIDASE A WITH ZN REMOVED
Descriptor:APO-CARBOXYPEPTIDASE A=ALPHA= (COX)
Authors:Greenblatt, H.M., Feinberg, H., Tucker, P.A., Shoham, G.
Deposit date:1994-11-22
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.
Acta Crystallogr.,Sect.D, 54, 1998
1ARM
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CARBOXYPEPTIDASE A WITH ZN REPLACED BY HG
Descriptor:HG-CARBOXYPEPTIDASE A=ALPHA= (COX), MERCURY (II) ION, COPPER (II) ION, ...
Authors:Greenblatt, H.M., Feinberg, H., Tucker, P.A., Shoham, G.
Deposit date:1994-11-22
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.
Acta Crystallogr.,Sect.D, 54, 1998
1DX6
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STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-GALANTHAMINE AT 2.3A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, TETRAETHYLENE GLYCOL, (-)-GALANTHAMINE, ...
Authors:Greenblatt, H.M., Kryger, G., Lewis, T.T., Silman, I., Sussman, J.L.
Deposit date:1999-12-21
Release date:2000-01-02
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Acetylcholinesterase Complexed with (-)-Galanthamine at 2.3A Resolution
FEBS Lett., 463, 1999
1W4L
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COMPLEX OF TCACHE WITH BIS-ACTING GALANTHAMINE DERIVATIVE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, GALANTHAMINE DERIVATIVE
Authors:Greenblatt, H.M., Guillou, C., Guenard, D., Badet, B., Thal, C., Silman, I., Sussman, J.L.
Deposit date:2004-07-25
Release date:2004-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:The Complex of a Bivalent Derivative of Galanthamine with Torpedo Acetycholinesterase Displays Drastic Deformation of the Active-Site Gorge: Implications for Structure-Based Drug Design
J.Am.Chem.Soc., 126, 2004
1W6R
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COMPLEX OF TCACHE WITH GALANTHAMINE DERIVATIVE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, (-)-GALANTHAMINE, ...
Authors:Greenblatt, H.M., Guillou, C., Guenard, D., Badet, B., Thal, C., Silman, I., Sussman, J.L.
Deposit date:2004-08-23
Release date:2004-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Complex of a Bivalent Derivative of Galanthamine with Torpedo Acetycholinesterase Displays Drastic Deformation of the Active-Site Gorge: Implications for Structure-Based Drug Design
J.Am.Chem.Soc., 126, 2004
1W75
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NATIVE ORTHORHOMBIC FORM OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE (ACHE)
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE
Authors:Greenblatt, H.M., Botti, S., Argaman, A., Silman, I., Sussman, J.L.
Deposit date:2004-08-29
Release date:2004-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Complex of a Bivalent Derivative of Galanthamine with Torpedo Acetycholinesterase Displays Drastic Deformation of the Active-Site Gorge: Implications for Structure-Based Drug Design
J.Am.Chem.Soc., 126, 2004
1W76
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ORTHORHOMBIC FORM OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE (ACHE) COMPLEXED WITH BIS-ACTING GALANTHAMINE DERIVATIVE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, (-)-GALANTHAMINE
Authors:Greenblatt, H.M., Guillou, C., Guenard, D., Badet, B., Thal, C., Silman, I., Sussman, J.L.
Deposit date:2004-08-30
Release date:2004-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Complex of a Bivalent Derivative of Galanthamine with Torpedo Acetycholinesterase Displays Drastic Deformation of the Active-Site Gorge: Implications for Structure-Based Drug Design
J.Am.Chem.Soc., 126, 2004
1YME
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STRUCTURE OF CARBOXYPEPTIDASE
Descriptor:CARBOXYPEPTIDASE A ALPHA, ZINC ION
Authors:Greenblatt, H.M., Tucker, P.A., Shoham, G.
Deposit date:1996-07-15
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.
Acta Crystallogr.,Sect.D, 54, 1998
4AB1
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RECOMBINANT HUMAN CARBOXYLESTERASE 1 FROM WHOLE CABBAGE LOOPERS
Descriptor:LIVER CARBOXYLESTERASE 1, N-ACETYL-D-GLUCOSAMINE, THIOCYANATE ION
Authors:Greenblatt, H.M., Otto, T.C., Cerasoli, D.M., Sussman, J.L.
Deposit date:2011-12-06
Release date:2012-03-07
Last modified:2012-05-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae.
Acta Crystallogr.,Sect.F, 68, 2012
1SOM
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENT GD (SOMAN).
Descriptor:PROTEIN (ACETYLCHOLINESTERASE), N-ACETYL-D-GLUCOSAMINE, UNKNOWN ATOM OR ION, ...
Authors:Greenblatt, H.M., Millard, C.B., Sussman, J.L., Silman, I.
Deposit date:1999-03-17
Release date:1999-06-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38, 1999
1HBJ
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X-RAY CRYSTAL STRUCTURE OF COMPLEX BETWEEN TORPEDO CALIFORNICA ACHE AND A REVERSIBLE INHIBITOR, 4-AMINO-5-FLUORO-2-METHYL-3-(3-TRIFLUOROACETYLBENZYLTHIOMETHYL)QUINOLINE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL, ...
Authors:Greenblatt, H.M., Kryger, G., Lewis, T.L., Doucet, C., Viner, R., Silman, I., Sussman, J.L.
Deposit date:2001-04-16
Release date:2001-09-25
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Structure-Based Design Approach to the Development of Novel, Reversible Ache Inhibitors
J.Med.Chem., 44, 2001
1CP7
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AMINOPEPTIDASE FROM STREPTOMYCES GRISEUS
Descriptor:AMINOPEPTIDASE, ZINC ION, CALCIUM ION
Authors:Gilboa, R., Greenblatt, H.M., Perach, M., Spungin-Bialik, A., Lessel, U., Schomburg, D., Blumberg, S., Shoham, G.
Deposit date:1999-06-10
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
1QQ9
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STREPTOMYCES GRISEUS AMINOPEPTIDASE COMPLEXED WITH METHIONINE
Descriptor:AMINOPEPTIDASE, ZINC ION, CALCIUM ION, ...
Authors:Gilboa, R., Greenblatt, H.M., Perach, M., Spungin-Bialik, A., Lessel, U., Schomburg, D., Blumberg, S., Shoham, G.
Deposit date:1999-06-12
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
1ZGC
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CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (RS)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
1ODC
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9"-(1",2",3",4"-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.2A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-QUINOLIN-4-YL-N'-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-02-15
Release date:2005-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
1UT6
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.4 ANGSTROMS RESOLUTION.
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE
Authors:Brumshtein, B., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-12-04
Release date:2005-04-21
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
1ZGB
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CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (R)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5R)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
1H22
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(10)-HUPYRIDONE AT 2.15A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,10-DIAMINODECANE DIHYDROCHLORIDE, N-ACETYL-D-GLUCOSAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2002-07-30
Release date:2002-12-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J.Am.Chem.Soc., 125, 2003
1H23
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, N-ACETYL-D-GLUCOSAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.F., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2002-07-30
Release date:2002-12-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J.Am.Chem.Soc., 125, 2003
1M4L
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STRUCTURE OF NATIVE CARBOXYPEPTIDASE A AT 1.25 RESOLUTION
Descriptor:CARBOXYPEPTIDASE A, ZINC ION
Authors:Kilshtain-Vardi, A., Glick, M., Greenblatt, H.M., Goldblum, A., Shoham, G.
Deposit date:2002-07-03
Release date:2003-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Refined structure of bovine carboxypeptidase A at 1.25 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
1Y7W
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CRYSTAL STRUCTURE OF A HALOTOLERANT CARBONIC ANHYDRASE FROM DUNALIELLA SALINA
Descriptor:Halotolerant alpha-type carbonic anhydrase (dCA II), SODIUM ION, ZINC ION, ...
Authors:Premkumar, L., Greenblatt, H.M., Bageshwar, U.K., Savchenko, T., Gokhman, I., Sussman, J.L., Zamir, A., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-12-10
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2C4H
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 500MM ACETYLTHIOCHOLINE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, TRIETHYLENE GLYCOL, ...
Authors:Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M.
Deposit date:2005-10-19
Release date:2006-06-14
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into substrate traffic and inhibition in acetylcholinesterase.
EMBO J., 25, 2006
2C58
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 20MM ACETYLTHIOCHOLINE
Descriptor:ACETYLCHOLINESTERASE, 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, ACETYLTHIOCHOLINE, ...
Authors:Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M.
Deposit date:2005-10-26
Release date:2006-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.
Embo J., 25, 2006
2C5F
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N-TRIMETHYLPENTANAMINIUM
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, TRIETHYLENE GLYCOL, ...
Authors:Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M.
Deposit date:2005-10-27
Release date:2006-06-14
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.
Embo J., 25, 2006
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