Author results

1JMT
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X-RAY STRUCTURE OF A CORE U2AF65/U2AF35 HETERODIMER
Descriptor:SPLICING FACTOR U2AF 35 KDA SUBUNIT, SPLICING FACTOR U2AF 65 KDA SUBUNIT, HEXANE-1,6-DIOL
Authors:Kielkopf, C.L., Rodionova, N.A., Green, M.R., Burley, S.K.
Deposit date:2001-07-19
Release date:2001-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer.
Cell(Cambridge,Mass.), 106, 2001
1T5I
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF UAP56
Descriptor:C_TERMINAL DOMAIN OF A PROBABLE ATP-DEPENDENT RNA HELICASE
Authors:Zhao, R., Green, M.R., Shen, J.
Deposit date:2004-05-04
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of UAP56, a "DEXD/H-box" protein involved in pre-mRNA splicing and mRNA export
Structure, 12, 2004
1U2F
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SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN OF HU2AF65
Descriptor:PROTEIN (SPLICING FACTOR U2AF 65 KD SUBUNIT)
Authors:Ito, T., Muto, Y., Green, M.R., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1999-05-26
Release date:1999-08-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)).
EMBO J., 18, 1999
2U2F
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SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN OF HU2AF65
Descriptor:PROTEIN (SPLICING FACTOR U2AF 65 KD SUBUNIT)
Authors:Ito, T., Muto, Y., Green, M.R., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1999-05-26
Release date:1999-08-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)).
EMBO J., 18, 1999
1BHI
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STRUCTURE OF TRANSACTIVATION DOMAIN OF CRE-BP1/ATF-2, NMR, 20 STRUCTURES
Descriptor:CRE-BP1
Authors:Nagadoi, A., Nakazawa, K., Uda, H., Maekawa, T., Ishii, S., Nishimura, Y.
Deposit date:1998-06-09
Release date:1999-06-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain.
J.Mol.Biol., 287, 1999
1T6N
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN UAP56
Descriptor:Probable ATP-dependent RNA helicase, CITRATE ANION
Authors:Zhao, R.
Deposit date:2004-05-06
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal Structure of UAP56, a DExD/H-Box Protein Involved in Pre-mRNA Splicing and mRNA Export
Structure, 12, 2004
2G4B
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STRUCTURE OF U2AF65 VARIANT WITH POLYURIDINE TRACT
Descriptor:5'-R(P*UP*UP*UP*UP*UP*UP*U)-3', Splicing factor U2AF 65 kDa subunit, 1,4-DIETHYLENE DIOXIDE
Authors:Sickmier, E.A., Kielkopf, C.L.
Deposit date:2006-02-21
Release date:2006-07-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of polypyrimidine tract recognition by the essential splicing factor U2AF65.
Mol.Cell, 23, 2006
3VAF
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STRUCTURE OF U2AF65 VARIANT WITH BRU3 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA 5'-D(*UP*UP*(BRU)P*(BRU)P*UP*UP*U)-3', 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAG
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STRUCTURE OF U2AF65 VARIANT WITH BRU3C2 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA 5'-D(*U*CP*(BRU)P*UP*UP*UP*U)-3', 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAH
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STRUCTURE OF U2AF65 VARIANT WITH BRU3C4 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA 5'-D(P*UP*UP*(BRU)P*CP*UP*UP*U)-3', 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAI
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STRUCTURE OF U2AF65 VARIANT WITH BRU3C5 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA 5'-D(*UP*UP*(BRU)P*UP*CP*UP*U)-3', 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Frato, K.H., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAJ
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STRUCTURE OF U2AF65 VARIANT WITH BRU5C6 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*CP*U)-3'), 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAK
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STRUCTURE OF U2AF65 VARIANT WITH BRU5 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAL
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STRUCTURE OF U2AF65 VARIANT WITH BRU5C1 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA (5'-D(*C*UP*UP*UP*(BRU)P*UP*U)-3'), 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Frato, K.H., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAM
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STRUCTURE OF U2AF65 VARIANT WITH BRU5C2 DNA
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA (5'-D(*UP*CP*UP*UP*(BRU)P*UP*U)-3'), 1,4-DIETHYLENE DIOXIDE, ...
Authors:Jenkins, J.L., Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
4FXW
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STRUCTURE OF PHOSPHORYLATED SF1 COMPLEX WITH U2AF65-UHM DOMAIN
Descriptor:Splicing factor U2AF 65 kDa subunit, Splicing factor 1, SULFATE ION
Authors:Wang, W., Bauer, W.J., Wedekind, J.E., Kielkopf, C.L.
Deposit date:2012-07-03
Release date:2013-01-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of Phosphorylated SF1 Bound to U2AF(65) in an Essential Splicing Factor Complex.
Structure, 21, 2013
4FXX
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STRUCTURE OF SF1 COILED-COIL DOMAIN
Descriptor:Splicing factor 1, IMIDAZOLE, MALONATE ION
Authors:Gupta, A., Bauer, W.J., Wang, W., Kielkopf, C.L.
Deposit date:2012-07-03
Release date:2013-01-16
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.4801 Å)
Cite:Structure of Phosphorylated SF1 Bound to U2AF(65) in an Essential Splicing Factor Complex.
Structure, 21, 2013
4OZ0
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CRYSTAL STRUCTURE OF HUMAN CAPERALPHA U2AF HOMOLOGY MOTIF (APO-STATE)
Descriptor:RNA-binding protein 39, CHLORIDE ION
Authors:Loerch, S., Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
4OZ1
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CRYSTAL STRUCTURE OF HUMAN CAPERALPHA UHM BOUND TO SF3B155 ULM5
Descriptor:RNA-binding protein 39, Splicing factor 3B subunit 1, POTASSIUM ION, ...
Authors:Loerch, S., Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
5EV1
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STRUCTURE I OF INTACT U2AF65 RECOGNIZING A 3' SPLICE SITE SIGNAL
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(*UP*UP*U)-D(P*UP*UP*(BRU)P*U)-R(P*UP*U)-3'), SODIUM ION, ...
Authors:Agrawal, A.A., Jenkins, J.L., Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.037 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV2
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STRUCTURE II OF INTACT U2AF65 RECOGNIZING THE 3' SPLICE SITE SIGNAL
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA (5'-R(P*UP*U)-D(P*UP*U)-R(P*U)-D(P*UP*(BRU)P*U)-3'), 1,4-DIETHYLENE DIOXIDE, ...
Authors:Agrawal, A.A., Jenkins, J.L., Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV3
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STRUCTURE III OF INTACT U2AF65 RECOGNIZING THE 3' SPLICE SITE SIGNAL
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)-3')
Authors:Agrawal, A.A., Jenkins, J.L., Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV4
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STRUCTURE IV OF INTACT U2AF65 RECOGNIZING THE 3' SPLICE SITE SIGNAL
Descriptor:Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*UP*UP*(UD)P*UP*U)-D(P*(BRU)P*(UD))-R(P*C)-3'), GLYCEROL
Authors:Agrawal, A.A., Jenkins, J.L., Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
2HZC
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CRYSTAL STRUCTURE OF THE N-TERMINAL RRM OF THE U2AF LARGE SUBUNIT
Descriptor:Splicing factor U2AF 65 kDa subunit, ZINC ION, HEXAETHYLENE GLYCOL
Authors:Thickman, K.R., Sickmier, E.A., Kielkopf, C.L.
Deposit date:2006-08-08
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF(65) RNA Recognition Motif.
J.Mol.Biol., 366, 2007
2YH1
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MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING
Descriptor:SPLICING FACTOR U2AF 65 KDA SUBUNIT, 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3'
Authors:Mackereth, C.D., Madl, T., Simon, B., Zanier, K., Gasch, A., Sattler, M.
Deposit date:2011-04-26
Release date:2011-07-20
Last modified:2011-07-27
Method:SOLUTION NMR
Cite:Multi-Domain Conformational Selection Underlies Pre-Mrna Splicing Regulation by U2Af
Nature, 475, 2011