Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1ESL
DownloadVisualize
BU of 1esl by Molmil
INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS
Descriptor: CALCIUM ION, CHLORIDE ION, HUMAN E-SELECTIN
Authors:Graves, B.J, Crowther, R.L.
Deposit date:1994-06-03
Release date:1994-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.
Nature, 367, 1994
2ILA
DownloadVisualize
BU of 2ila by Molmil
STRUCTURE OF INTERLEUKIN 1ALPHA AT 2.7-ANGSTROMS RESOLUTION
Descriptor: INTERLEUKIN-1 ALPHA
Authors:Graves, B.J, Hatada, M.H.
Deposit date:1991-05-01
Release date:1992-10-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of interleukin 1 alpha at 2.7-A resolution.
Biochemistry, 29, 1990
3KMM
DownloadVisualize
BU of 3kmm by Molmil
Structure of human LCK kinase with a small molecule inhibitor
Descriptor: 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION
Authors:Graves, B.J, Surgenor, A, Harris, W, Smith, I, Orchard, S, Flotow, H, Murray, E.
Deposit date:2009-11-10
Release date:2010-12-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of human LCK kinase with a small molecule inhibitor
To be Published
1HXB
DownloadVisualize
BU of 1hxb by Molmil
HIV-1 proteinase complexed with RO 31-8959
Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, HIV-1 PROTEASE
Authors:Graves, B.J, Hatada, M.H, Crowther, R.L.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.
J.Med.Chem., 34, 1991
1R36
DownloadVisualize
BU of 1r36 by Molmil
NMR-based structure of autoinhibited murine Ets-1 deltaN301
Descriptor: C-ets-1 protein
Authors:Lee, G.M, Donaldson, L.W, Pufall, M.A, Kang, H.-S, Pot, I, Graves, B.J, McIntosh, L.P.
Deposit date:2003-09-30
Release date:2004-11-09
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition
J.Biol.Chem., 280, 2005
6DA1
DownloadVisualize
BU of 6da1 by Molmil
ETS1 in complex with synthetic SRR mimic
Descriptor: Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide
Authors:Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P.
Deposit date:2018-05-01
Release date:2019-01-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.000127 Å)
Cite:The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor.
J. Mol. Biol., 431, 2019
6DAT
DownloadVisualize
BU of 6dat by Molmil
ETS1 in complex with synthetic SRR mimic
Descriptor: Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide
Authors:Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P.
Deposit date:2018-05-02
Release date:2019-01-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.35002637 Å)
Cite:The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor.
J. Mol. Biol., 431, 2019
1MDM
DownloadVisualize
BU of 1mdm by Molmil
INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA
Descriptor: C-ETS-1 PROTEIN, PAIRED BOX PROTEIN PAX-5, PAX5/ETS BINDING SITE ON THE MB-1 PROMOTER
Authors:Garvie, C.W, Pufall, M.A, Graves, B.J, Wolberger, C.
Deposit date:2002-08-07
Release date:2002-12-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:STRUCTURAL ANALYSIS OF THE AUTOINHIBITION OF ETS-1 AND ITS ROLE IN PROTEIN PARTNERSHIPS
J.Biol.Chem., 277, 2002
1MD0
DownloadVisualize
BU of 1md0 by Molmil
CRYSTAL STRUCTURE OF AN INHIBITED FRAGMENT OF Ets-1
Descriptor: C-ets-1 protein
Authors:Garvie, C.W, Pufall, M.A, Graves, B.J, Wolberger, C.
Deposit date:2002-08-06
Release date:2002-12-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of the Autoinhibition of Ets-1 and Its Role in Protein Partnerships
J.Biol.Chem., 277, 2002
2JUO
DownloadVisualize
BU of 2juo by Molmil
GABPa OST domain
Descriptor: GA-binding protein alpha chain
Authors:Kang, H, Nelson, M.L, Mackereth, C.D, Schaerpf, M, Graves, B.J, McIntosh, L.P.
Deposit date:2007-08-31
Release date:2008-04-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha
J.Mol.Biol., 377, 2008
2KMD
DownloadVisualize
BU of 2kmd by Molmil
Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to co-activator CBP
Descriptor: Protein C-ets-1
Authors:Nelson, M.L, Kang, H, Lee, G.M, Blaszczak, A.G, Lau, D.K.W, McIntosh, L.P, Graves, B.J.
Deposit date:2009-07-27
Release date:2010-05-05
Last modified:2012-03-21
Method:SOLUTION NMR
Cite:Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.
Proc.Natl.Acad.Sci.USA, 107, 2010
2LF8
DownloadVisualize
BU of 2lf8 by Molmil
Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458
Descriptor: Transcription factor ETV6
Authors:Coyne III, H, Green, S.M, Graves, B.J, Mcintosh, L.P.
Deposit date:2011-06-28
Release date:2012-05-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain.
J.Mol.Biol., 421, 2012
2LF7
DownloadVisualize
BU of 2lf7 by Molmil
Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to Q436
Descriptor: Transcription factor ETV6
Authors:Coyne III, H, Green, S.M, Graves, B.J, Mcintosh, L.P.
Deposit date:2011-06-28
Release date:2012-05-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain.
J.Mol.Biol., 421, 2012
4MHG
DownloadVisualize
BU of 4mhg by Molmil
Crystal structure of ETV6 bound to a specific DNA sequence
Descriptor: Complementary Specific 14 bp DNA, Specific 14 bp DNA, Transcription factor ETV6
Authors:Chan, A.C, De, S, Coyne III, H.J, Okon, M, Murphy, M.E, Graves, B.J, McIntosh, L.P.
Deposit date:2013-08-29
Release date:2014-01-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
J.Mol.Biol., 426, 2014
2MD5
DownloadVisualize
BU of 2md5 by Molmil
Structure of uninhibited ETV6 ETS domain
Descriptor: Transcription factor ETV6
Authors:De, S, Mcintosh, L.P, Chan, A.C, Coyne, H.J, Okon, M, Graves, B.J, Murphy, M.E.
Deposit date:2013-08-29
Release date:2013-12-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
J.Mol.Biol., 426, 2014
8GJS
DownloadVisualize
BU of 8gjs by Molmil
Stapled Peptide ALRN-6924 Bound to MDMX
Descriptor: ACE-LEU-THR-PHE-ALA-GLU-TYR-TRP-ALA-GLN-LEU-DAL-ALA-ALA-ALA-ALA-ALA-DAL, Protein Mdm4
Authors:Graves, B.J, Janson, C, Lukacs, C.
Deposit date:2023-03-16
Release date:2023-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized alpha-Helical Peptide in Clinical Development.
J.Med.Chem., 66, 2023
4LWV
DownloadVisualize
BU of 4lwv by Molmil
The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353
Descriptor: (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Graves, B.J, Lukacs, C, Janson, C.A.
Deposit date:2013-07-28
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development.
ACS MED.CHEM.LETT., 5, 2014
4LWT
DownloadVisualize
BU of 4lwt by Molmil
The 1.6A Crystal Structure of Humanized Xenopus MDM2 with RO5027344
Descriptor: (3S)-3-[(3R)-1-acetylpiperidin-3-yl]-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-2H-indol-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Graves, B.J, Lukacs, C, Kammlott, U.
Deposit date:2013-07-28
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Bioorg.Med.Chem., 22, 2014
4LWU
DownloadVisualize
BU of 4lwu by Molmil
The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252
Descriptor: (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Graves, B.J, Lukacs, C, Janson, C.A.
Deposit date:2013-07-28
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Bioorg.Med.Chem., 22, 2014
4N5T
DownloadVisualize
BU of 4n5t by Molmil
The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041
Descriptor: ATSP-7041 stapled-peptide, Protein Mdm4
Authors:Graves, B.J, Lukacs, C, Janson, C.A.
Deposit date:2013-10-10
Release date:2013-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J3E
DownloadVisualize
BU of 4j3e by Molmil
The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
Descriptor: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Graves, B.J, Lukacs, C.M, Kammlott, R.U, Crowther, R.
Deposit date:2013-02-05
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ACS Med Chem Lett, 4, 2013
4IPF
DownloadVisualize
BU of 4ipf by Molmil
The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337
Descriptor: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone
Authors:Graves, B.J, Lukacs, C, Kammlott, R.U, Crowther, R.
Deposit date:2013-01-09
Release date:2013-02-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models.
Cancer Res., 73, 2013
4JRG
DownloadVisualize
BU of 4jrg by Molmil
The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor
Descriptor: (3R,4R,5S)-3-(3-chlorophenyl)-4-(4-chlorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide, E3 ubiquitin-protein ligase Mdm2
Authors:Graves, B.J, Janson, C.A, Lukacs, C.
Deposit date:2013-03-21
Release date:2013-07-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development.
J.Med.Chem., 56, 2013
3U15
DownloadVisualize
BU of 3u15 by Molmil
Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443
Descriptor: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, Protein Mdm4, SULFATE ION
Authors:Lukacs, C.M, Janson, C.A, Graves, B.J.
Deposit date:2011-09-29
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc.Natl.Acad.Sci.USA, 109, 2012
3VBG
DownloadVisualize
BU of 3vbg by Molmil
Structure of hDM2 with Dimer Inducing Indolyl Hydantoin RO-2443
Descriptor: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, E3 ubiquitin-protein ligase Mdm2
Authors:Lukacs, C.M, Janson, C.A, Graves, B.J.
Deposit date:2012-01-02
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc.Natl.Acad.Sci.USA, 109, 2012

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon