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5FV7
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BU of 5fv7 by Molmil
Human Fen1 in complex with an N-hydroxyurea compound
Descriptor: 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, FLAP ENDONUCLEASE 1, MAGNESIUM ION
Authors:Exell, J.C, Thompson, M.J, Finger, L.D, Shaw, S.K, Abbott, W.M, McWhirter, C, Debreczeni, J.E, Jones, C.D, Nissink, J.W.M, Ward, T.A, Sioberg, C.W.L, Molina, D.M, Durant, S.T, Grasby, J.A.
Deposit date:2016-02-03
Release date:2016-08-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site
Nat.Chem.Biol., 12, 2016
3Q8K
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BU of 3q8k by Molmil
Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+, and K+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A.
Deposit date:2011-01-06
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2001 Å)
Cite:Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3Q8M
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BU of 3q8m by Molmil
Crystal Structure of Human Flap Endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and K+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A.
Deposit date:2011-01-06
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3Q8L
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BU of 3q8l by Molmil
Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+, and K+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A.
Deposit date:2011-01-06
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.319 Å)
Cite:Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
5KSE
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BU of 5kse by Molmil
Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2016-07-08
Release date:2017-06-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5K97
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BU of 5k97 by Molmil
Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2016-05-31
Release date:2017-06-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5UM9
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BU of 5um9 by Molmil
Flap endonuclease 1 (FEN1) D86N with 5'-flap substrate DNA and Sm3+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2017-01-26
Release date:2017-06-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
4HDV
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BU of 4hdv by Molmil
Crystal structure of S. pombe ATL1 in complex with damaged DNA containing 2,6-diaminopurine
Descriptor: 5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3', 5'-D(*GP*CP*CP*AP*TP*GP*(1AP)P*CP*TP*AP*GP*TP*A)-3', Alkyltransferase-like protein 1
Authors:Tubbs, J.L, Tainer, J.A.
Deposit date:2012-10-02
Release date:2012-12-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-{pi} interactions.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HDU
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BU of 4hdu by Molmil
Crystal structure of S. pombe ATL1 in complex with damaged DNA containing 2-aminopurine
Descriptor: 5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3', 5'-D(*GP*CP*CP*AP*TP*GP*(2PR)P*CP*TP*AP*GP*TP*A)-3', Alkyltransferase-like protein 1
Authors:Tubbs, J.L, Tainer, J.A.
Deposit date:2012-10-02
Release date:2012-12-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.848 Å)
Cite:Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-{pi} interactions.
Proc.Natl.Acad.Sci.USA, 109, 2012

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PDB entries from 2024-03-27

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