8PE3
 
 | | Structure of Csm6' from Streptococcus thermophilus in complex with cyclic hexa-adenylate (cA6) | | Descriptor: | CRISPR system endoribonuclease Csm6', Cyclic hexaadenosine monophosphate (cA6), RNA | | Authors: | McQuarrie, S.J, Athukoralage, J.S, McMahon, S.A, Graham, S, Ackerman, K, Bode, B.E, White, M.F, Gloster, T.M. | | Deposit date: | 2023-06-13 | | Release date: | 2023-10-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open.
Nucleic Acids Res., 51, 2023
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8PCW
 | | Structure of Csm6' from Streptococcus thermophilus | | Descriptor: | CRISPR system endoribonuclease Csm6' | | Authors: | McQuarrie, S.J, Athukoralage, J.S, McMahon, S.A, Graham, S, Ackerman, K, Bode, B.E, White, M.F, Gloster, T.M. | | Deposit date: | 2023-06-11 | | Release date: | 2023-10-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.54 Å) | | Cite: | Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open.
Nucleic Acids Res., 51, 2023
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6YUD
 | | Structure of Csx3/Crn3 from Archaeoglobus fulgidus in complex with cyclic tetra-adenylate (cA4) | | Descriptor: | Cyclic tetraadenosine monophosphate (cA4), Uncharacterized protein AF_1864 | | Authors: | McQuarrie, S, Gloster, T.M, White, M.F, Graham, S, Athukoralage, J.S, Gruschow, S. | | Deposit date: | 2020-04-27 | | Release date: | 2020-08-19 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage.
Elife, 9, 2020
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7BDV
 | | Structure of Can2 from Sulfobacillus thermosulfidooxidans in complex with cyclic tetra-adenylate (cA4) | | Descriptor: | Can2, Cyclic tetraadenosine monophosphate (cA4) | | Authors: | McQuarrie, S, McMahon, S.A, Gloster, T.M, White, M.F, Graham, S, Zhu, W, Gruschow, S. | | Deposit date: | 2020-12-22 | | Release date: | 2021-03-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.
Nucleic Acids Res., 49, 2021
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3TEK
 | | ThermoDBP: a non-canonical single-stranded DNA binding protein with a novel structure and mechanism | | Descriptor: | ThermoDBP-single stranded DNA binding protein | | Authors: | White, M.F, Paytubi, S, Liu, H, Graham, S, McMahon, S.A, Naismith, J.H. | | Deposit date: | 2011-08-15 | | Release date: | 2011-11-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6SCF
 | | A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate | | Descriptor: | Uncharacterized protein, cyclic oligoadenylate | | Authors: | McMahon, S.A, Athukoralage, J.S, Graham, S, White, M.F, Gloster, T.M. | | Deposit date: | 2019-07-24 | | Release date: | 2019-10-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity.
Nature, 577, 2020
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8B2X
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8ANE
 | | Structure of the type I-G CRISPR effector | | Descriptor: | Cas7, RNA (66-MER) | | Authors: | Shangguan, Q, Graham, S, Sundaramoorthy, R, White, M.F. | | Deposit date: | 2022-08-05 | | Release date: | 2022-11-09 | | Last modified: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure and mechanism of the type I-G CRISPR effector.
Nucleic Acids Res., 50, 2022
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6SCE
 | | Structure of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate | | Descriptor: | Uncharacterized protein, cyclic oligoadenylate | | Authors: | McMahon, S.A, Zhu, W, Graham, S, White, M.F, Gloster, T.M. | | Deposit date: | 2019-07-24 | | Release date: | 2020-02-19 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate.
Nat Commun, 11, 2020
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2WZL
 | | The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein | | Descriptor: | GLYCEROL, PHOSPHOPROTEIN | | Authors: | Assenberg, R, Delmas, O, Ren, J, Vidalain, P, Verma, A, Larrous, F, Graham, S, Tangy, F, Grimes, J, Bourhy, H. | | Deposit date: | 2009-11-30 | | Release date: | 2009-12-15 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Structure of the N-RNA Binding Domain of the Mokola Virus Phosphoprotein
J.Virol., 84, 2010
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3FKT
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7YAR
 | | ZIKV_Fab_G9E | | Descriptor: | E protein, M protein, heavy chain, ... | | Authors: | Shu, B, Thiam-Seng, N, Lok, S. | | Deposit date: | 2022-06-28 | | Release date: | 2023-01-04 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus.
Plos Pathog., 19, 2023
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8BMW
 | | SsoCsm | | Descriptor: | CRISPR-associated Cas7 paralog (Type III-D), CRISPR-associated protein Cas10 (Type III-D), CRISPR-associated protein Cas5 (Type III-D), ... | | Authors: | Spagnolo, L, White, M.F. | | Deposit date: | 2022-11-11 | | Release date: | 2023-03-01 | | Last modified: | 2023-03-22 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the Saccharolobus solfataricus type III-D CRISPR effector.
Curr Res Struct Biol, 5, 2023
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7QQK
 | | TIR-SAVED effector bound to cA3 | | Descriptor: | RNA (5'-R(P*AP*AP*A)-3'), TIR_SAVED fusion protein | | Authors: | Spagnolo, L, White, M.F, Hogrel, G, Guild, A. | | Deposit date: | 2022-01-09 | | Release date: | 2022-06-15 | | Last modified: | 2022-09-07 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cyclic nucleotide-induced helical structure activates a TIR immune effector.
Nature, 608, 2022
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2IRZ
 | | Crystal structure of human Beta-secretase complexed with inhibitor | | Descriptor: | 3-{5-[(1R)-1-AMINO-1-METHYL-2-PHENYLETHYL]-1,3,4-OXADIAZOL-2-YL}-N-[(1R)-1-(4-FLUOROPHENYL)ETHYL]-5-[METHYL(METHYLSULFONYL)AMINO]BENZAMIDE, Beta-secretase 1 | | Authors: | Munshi, S. | | Deposit date: | 2006-10-16 | | Release date: | 2006-11-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
J.Med.Chem., 49, 2006
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2IS0
 | | Crystal structure of human Beta-secretase complexed with inhibitor | | Descriptor: | (2S)-2-AMINO-2-BENZYL-3-HYDROXYPROPYL 3-({[(1R)-1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)-5-[METHYL(METHYLSULFONYL)AMINO]BENZOATE, Beta-secretase 1 | | Authors: | Munshi, S. | | Deposit date: | 2006-10-16 | | Release date: | 2006-11-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
J.Med.Chem., 49, 2006
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8DV6
 | | Zika virus envelope protein structure in complex with a potent Human mAb | | Descriptor: | Envelope protein E, mAb Fab Heavy Chain, mAb Fab Light Chain | | Authors: | Cameron, A, Puhl, A.C, deSilva, A.M, Premkumar, L. | | Deposit date: | 2022-07-28 | | Release date: | 2023-01-04 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.38 Å) | | Cite: | Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus.
Plos Pathog., 19, 2023
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5V2A
 | | Crystal structure of Fab H7.167 in complex with influenza virus hemagglutinin from A/Shanghai/02/2013 (H7N9) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H7.167 antibody, Hemagglutinin, ... | | Authors: | Zhang, H, Zhu, X, Wilson, I.A. | | Deposit date: | 2017-03-03 | | Release date: | 2017-04-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (4.656 Å) | | Cite: | H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.
J. Clin. Invest., 126, 2016
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3PS0
 | | The structure of the CRISPR-associated protein, csa2, from Sulfolobus solfataricus | | Descriptor: | CRISPR-Associated protein, CSA2 | | Authors: | Lintner, N.G, Sdano, M, Young, M.J, Lawrence, C.M. | | Deposit date: | 2010-11-30 | | Release date: | 2011-04-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE).
J.Biol.Chem., 286, 2011
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3ZFV
 | | Crystal structure of an archaeal CRISPR-associated Cas6 nuclease | | Descriptor: | CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1, GLYCEROL | | Authors: | Reeks, J, Liu, H, White, M.F, Naismith, J.H. | | Deposit date: | 2012-12-12 | | Release date: | 2013-04-03 | | Last modified: | 2013-05-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of a Dimeric Crenarchaeal Cas6 Enzyme with an Atypical Active Site for Crispr RNA Processing
Biochem.J., 452, 2013
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3ZC4
 | | The structure of Csa5 from Sulfolobus solfataricus. | | Descriptor: | DI(HYDROXYETHYL)ETHER, SSO1398 | | Authors: | Reeks, J, Anderson, L, White, M.F, Naismith, J.H. | | Deposit date: | 2012-11-15 | | Release date: | 2013-02-20 | | Last modified: | 2013-07-31 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structure of the Archaeal Cascade Subunit Csa5: Relating the Small Subunits of Crispr Effector Complexes.
RNA Biol., 10, 2013
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2XVO
 | | SSO1725, a protein involved in the CRISPR/Cas pathway | | Descriptor: | BETA-MERCAPTOETHANOL, SSO1725, SULFATE ION | | Authors: | Reeks, J, Liu, H, Naismith, J, White, M, McMahon, S. | | Deposit date: | 2010-10-26 | | Release date: | 2010-12-29 | | Last modified: | 2014-02-05 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structure and Mechanism of the Cmr Complex for Crispr-Mediated Antiviral Immunity.
Mol.Cell, 45, 2012
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4AI4
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4AI5
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4AIA
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