Author results

1AMH
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UNCOMPLEXED RAT TRYPSIN MUTANT WITH ASP 189 REPLACED WITH SER (D189S)
Descriptor:ANIONIC TRYPSIN, CALCIUM ION
Authors:Szabo, E., Bocskei, Z.S., Naray-Szabo, G., Graf, L.
Deposit date:1997-06-17
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The three-dimensional structure of Asp189Ser trypsin provides evidence for an inherent structural plasticity of the protease.
Eur.J.Biochem., 263, 1999
2F91
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1.2A RESOLUTION STRUCTURE OF A CRAYFISH TRYPSIN COMPLEXED WITH A PEPTIDE INHIBITOR, SGTI
Descriptor:hepatopancreas trypsin, Serine protease inhibitor I/II, CADMIUM ION, ...
Authors:Fodor, K., Harmat, V., Hetenyi, C., Kardos, J., Antal, J., Perczel, A., Patthy, A., Katona, G., Graf, L.
Deposit date:2005-12-05
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Enzyme:Substrate Hydrogen Bond Shortening during the Acylation Phase of Serine Protease Catalysis.
Biochemistry, 45, 2006
1H4W
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STRUCTURE OF HUMAN TRYPSIN IV (BRAIN TRYPSIN)
Descriptor:TRYPSIN IVA, BENZAMIDINE, CALCIUM ION
Authors:Katona, G., Berglund, G.I., Hajdu, J., Graf, L., Szilagyi, L.
Deposit date:2001-05-15
Release date:2002-02-11
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.
J. Mol. Biol., 315, 2002
1KDQ
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CRYSTAL STRUCTURE ANALYSIS OF THE MUTANT S189D RAT CHYMOTRYPSIN
Descriptor:CHYMOTRYPSIN B, B CHAIN, C CHAIN, ...
Authors:Szabo, E., Bocskei, Z., Naray-Szabo, G., Graf, L., Venekei, I.
Deposit date:2001-11-13
Release date:2003-06-10
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Three Dimensional Structures of S189D Chymotrypsin and D189S Trypsin Mutants: The Effect of Polarity at Site 189 on a Protease-specific Stabilization of the Substrate-binding Site
J.Mol.Biol., 331, 2003
1KGM
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SOLUTION STRUCTURE OF THE SMALL SERINE PROTEASE INHIBITOR SGCI
Descriptor:SERINE PROTEASE INHIBITOR I
Authors:Gaspari, Z., Patthy, A., Graf, L., Perczel, A.
Deposit date:2001-11-28
Release date:2001-12-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Comparative structure analysis of proteinase inhibitors from the desert locust, Schistocerca gregaria.
Eur.J.Biochem., 269, 2002
1KIO
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SOLUTION STRUCTURE OF THE SMALL SERINE PROTEASE INHIBITOR SGCI[L30R, K31M]
Descriptor:SERINE PROTEASE INHIBITOR I
Authors:Gaspari, Z., Patthy, A., Graf, L., Perczel, A.
Deposit date:2001-12-03
Release date:2001-12-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Comparative structure analysis of proteinase inhibitors from the desert locust, Schistocerca gregaria.
Eur.J.Biochem., 269, 2002
1KJ0
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SOLUTION STRUCTURE OF THE SMALL SERINE PROTEASE INHIBITOR SGTI
Descriptor:SERINE PROTEASE INHIBITOR I
Authors:Gaspari, Z., Patthy, A., Graf, L., Perczel, A.
Deposit date:2001-12-04
Release date:2001-12-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Comparative structure analysis of proteinase inhibitors from the desert locust, Schistocerca gregaria.
Eur.J.Biochem., 269, 2002
2JET
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CRYSTAL STRUCTURE OF A TRYPSIN-LIKE MUTANT (S189D , A226G) CHYMOTRYPSIN.
Descriptor:CHYMOTRYPSINOGEN B CHAIN A, CHYMOTRYPSINOGEN B CHAIN B, CHYMOTRYPSINOGEN B CHAIN C
Authors:Jelinek, B., Katona, G., Fodor, K., Venekei, I., Graf, L.
Deposit date:2007-01-22
Release date:2007-09-18
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Crystal Structure of a Trypsin-Like Mutant Chymotrypsin: The Role of Position 226 in the Activity and Specificity of S189D Chymotrypsin.
Protein J., 27, 2008
2QY0
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ACTIVE DIMERIC STRUCTURE OF THE CATALYTIC DOMAIN OF C1R REVEALS ENZYME-PRODUCT LIKE CONTACTS
Descriptor:Complement C1r subcomponent, GLYCEROL
Authors:Kardos, J., Harmat, V., Pallo, A., Barabas, O., Szilagyi, K., Graf, L., Naray-Szabo, G., Goto, Y., Zavodszky, P., Gal, P.
Deposit date:2007-08-13
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r.
Mol.Immunol., 45, 2008
2XTT
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BOVINE TRYPSIN IN COMPLEX WITH EVOLUTIONARY ENHANCED SCHISTOCERCA GREGARIA PROTEASE INHIBITOR 1 (SGPI-1-P02)
Descriptor:PROTEASE INHIBITOR SGPI-1, CATIONIC TRYPSIN, CALCIUM ION, ...
Authors:Wahlgren, W.Y., Pal, G., Kardos, J., Porrogi, P., Szenthe, B., Patthy, A., Graf, L., Katona, G.
Deposit date:2010-10-12
Release date:2010-11-10
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (0.93 Å)
Cite:The Catalytic Aspartate is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-Like Inhibitor: A Refined Mechanism of Serine Protease Action.
J.Biol.Chem., 286, 2011
4BNR
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EXTREMELY STABLE COMPLEX OF CRAYFISH TRYPSIN WITH BOVINE TRYPSIN INHIBITOR
Descriptor:HEPATOPANCREAS TRYPSIN, PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, ...
Authors:Molnar, T., Voros, J., Szeder, B., Takats, K., Kardos, J., Katona, G., Graf, L.
Deposit date:2013-05-17
Release date:2013-09-04
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparison of Complexes Formed by a Crustacean and a Vertebrate Trypsin with Bovine Pancreatic Trypsin Inhibitor - the Key to Achieving Extreme Stability?
FEBS J., 280, 2013
5GTM
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MODIFIED HUMAN MXA, NUCLEOTIDE-FREE FORM
Descriptor:Interferon-induced GTP-binding protein Mx1
Authors:Chen, Y., Gao, S.
Deposit date:2016-08-22
Release date:2017-05-31
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.896 Å)
Cite:Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
Nat Commun, 8, 2017
1IRK
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR
Descriptor:INSULIN RECEPTOR TYROSINE KINASE DOMAIN, ETHYL MERCURY ION
Authors:Hubbard, S.R., Wei, L., Ellis, L., Hendrickson, W.A.
Deposit date:1995-01-02
Release date:1995-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature, 372, 1994
1Q3X
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CRYSTAL STRUCTURE OF THE CATALYTIC REGION OF HUMAN MASP-2
Descriptor:Mannan-binding lectin serine protease 2, SODIUM ION, GLYCEROL
Authors:Harmat, V., Gal, P., Kardos, J., Szilagyi, K., Ambrus, G., Naray-Szabo, G., Zavodszky, P.
Deposit date:2003-08-01
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
J.Mol.Biol., 342, 2004