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3I9O
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH RIBO-2'F-ADP RIBOSE
Descriptor:ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Graeff, R., Liu, Q., Kriksunov, I.A., Kotaka, M., Oppenheimer, N., Hao, Q., Lee, H.C.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
J.Biol.Chem., 284, 2009
2HCT
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ACIDIC RESIDUES AT THE ACTIVE SITES OF CD38 AND ADP-RIBOSYL CYCLASE DETERMINE NAAPD SYNTHESIS AND HYDROLYSIS ACTIVITIES
Descriptor:ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Hao, Q., Graeff, R., Lee, H.C.
Deposit date:2006-06-18
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
J.Biol.Chem., 281, 2006
1R0S
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CRYSTAL STRUCTURE OF ADP-RIBOSYL CYCLASE GLU179ALA MUTANT
Descriptor:ADP-ribosyl cyclase
Authors:Love, M.L., Szebenyi, D.M.E., Kriksunov, I.A., Thiel, D.J., Munshi, C., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2003-09-22
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R12
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NATIVE APLYSIA ADP RIBOSYL CYCLASE
Descriptor:ADP-ribosyl cyclase
Authors:Love, M.L., Szebenyi, D.M.E., Kriksunov, I.A., Thiel, D.J., Munshi, C., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R15
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APLYSIA ADP RIBOSYL CYCLASE WITH BOUND NICOTINAMIDE AND R5P
Descriptor:ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, NICOTINAMIDE
Authors:Love, M.L., Szebenyi, D.M.E., Kriksunov, I.A., Thiel, D.J., Munshi, C., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R16
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APLYSIA ADP RIBOSYL CYCLASE WITH BOUND PYRIDYLCARBINOL AND R5P
Descriptor:ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, 3-PYRIDINYLCARBINOL
Authors:Love, M.L., Szebenyi, D.M.E., Kriksunov, I.A., Thiel, D.J., Munshi, C., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1YH3
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN
Descriptor:ADP-ribosyl cyclase 1
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Munshi, C., Lee, H.C., Hao, Q.
Deposit date:2005-01-06
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of human CD38 extracellular domain.
Structure, 13, 2005
2I65
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STRUCTURAL BASIS FOR THE MECHANISTIC UNDERSTANDING HUMAN CD38 CONTROLLED MULTIPLE CATALYSIS
Descriptor:ADP-ribosyl cyclase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Munshi, C., Lee, H.C., Hao, Q.
Deposit date:2006-08-28
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I66
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STRUCTURAL BASIS FOR THE MECHANISTIC UNDERSTANDING HUMAN CD38 CONTROLLED MULTIPLE CATALYSIS
Descriptor:ADP-ribosyl cyclase 1, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5S)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Munshi, C., Lee, H.C., Hao, Q.
Deposit date:2006-08-28
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I67
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STRUCTURAL BASIS FOR THE MECHANISTIC UNDERSTANDING HUMAN CD38 CONTROLLED MULTIPLE CATALYSIS
Descriptor:ADP-ribosyl cyclase 1, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Munshi, C., Lee, H.C., Hao, Q.
Deposit date:2006-08-28
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2O3Q
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STRUCTURAL BASIS FOR FORMATION AND HYDROLYSIS OF CALCIUM MESSENGER CYCLIC ADP-RIBOSE BY HUMAN CD38
Descriptor:ADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2006-12-01
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3R
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STRUCTURAL BASIS FOR FORMATION AND HYDROLYSIS OF CALCIUM MESSENGER CYCLIC ADP-RIBOSE BY HUMAN CD38
Descriptor:ADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2006-12-01
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3S
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STRUCTURAL BASIS FOR FORMATION AND HYDROLYSIS OF CALCIUM MESSENGER CYCLIC ADP-RIBOSE BY HUMAN CD38
Descriptor:ADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2006-12-01
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3T
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STRUCTURAL BASIS FOR FORMATION AND HYDROLYSIS OF CALCIUM MESSENGER CYCLIC ADP-RIBOSE BY HUMAN CD38
Descriptor:ADP-ribosyl cyclase 1, CYCLIC GUANOSINE DIPHOSPHATE-RIBOSE
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2006-12-01
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3U
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STRUCTURAL BASIS FOR FORMATION AND HYDROLYSIS OF CALCIUM MESSENGER CYCLIC ADP-RIBOSE BY HUMAN CD38
Descriptor:ADP-ribosyl cyclase 1, 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]PYRIDINIUM
Authors:Liu, Q., Kriksunov, I.A., Graeff, R., Lee, H.C., Hao, Q.
Deposit date:2006-12-01
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2PGJ
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CATALYSIS ASSOCIATED CONFORMATIONAL CHANGES REVEALED BY HUMAN CD38 COMPLEXED WITH A NON-HYDROLYZABLE SUBSTRATE ANALOG
Descriptor:ADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
Authors:Liu, Q., Kriksunov, I.A., Moreau, C., Graeff, R., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2007-04-09
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog
J.Biol.Chem., 282, 2007
2PGL
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CATALYSIS ASSOCIATED CONFORMATIONAL CHANGES REVEALED BY HUMAN CD38 COMPLEXED WITH A NON-HYDROLYZABLE SUBSTRATE ANALOG
Descriptor:ADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
Authors:Liu, Q., Kriksunov, I.A., Moreau, C., Graeff, R., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2007-04-09
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog
J.Biol.Chem., 282, 2007
3DZF
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN COMPLEXED WITH A COVALENT INTERMEDIATE, ARA-F-RIBOSE-5'-PHOSPHATE
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZG
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, ARA-F-RIBOSE-5'-PHOSPHATE/NICOTINAMIDE COMPLEX
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose, NICOTINAMIDE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZH
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, GTP COMPLEX
Descriptor:ADP-ribosyl cyclase 1, GUANOSINE-5'-TRIPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZI
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, RIBOSE-5'-PHOSPHATE INTERMEDIATE/GTP COMPLEX
Descriptor:ADP-ribosyl cyclase 1, 2-amino-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-9H-purin-6-yl 5-O-phosphono-beta-D-ribofuranoside, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, ...
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZJ
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN E226Q MUTANT, NMN COMPLEX
Descriptor:ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZK
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, NMN COMPLEX
Descriptor:ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3F6Y
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CONFORMATIONAL CLOSURE OF THE CATALYTIC SITE OF HUMAN CD38 INDUCED BY CALCIUM
Descriptor:ADP-ribosyl cyclase 1, CALCIUM ION
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Lam, C.M.C., Lee, H.C., Hao, Q.
Deposit date:2008-11-07
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium
Biochemistry, 47, 2008
3I9J
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH A SUBSTRATE ANALOG AND A PRODUCT NICOTINAMIDE
Descriptor:ADP-ribosyl cyclase, Nicotinamide 2-fluoro-adenine dinucleotide, [(2R,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ...
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
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