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3I9O
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BU of 3i9o by Molmil
Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose
Descriptor: ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Graeff, R, Liu, Q, Kriksunov, I.A, Kotaka, M, Oppenheimer, N, Hao, Q, Lee, H.C.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
J.Biol.Chem., 284, 2009
2HCT
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BU of 2hct by Molmil
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
Descriptor: ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q, Kriksunov, I.A, Hao, Q, Graeff, R, Lee, H.C.
Deposit date:2006-06-18
Release date:2006-08-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
J.Biol.Chem., 281, 2006
1YH3
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BU of 1yh3 by Molmil
Crystal structure of human CD38 extracellular domain
Descriptor: ADP-ribosyl cyclase 1
Authors:Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
Deposit date:2005-01-06
Release date:2005-09-27
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of human CD38 extracellular domain.
Structure, 13, 2005
3U4H
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BU of 3u4h by Molmil
CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
Descriptor: 8-Amino-N1-Cyclic Inosine 5'-Diphosphoribose, ADP-ribosyl cyclase 1
Authors:Liu, Q, Hao, Q, Lee, H.C, Graeff, R.
Deposit date:2011-10-08
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.878 Å)
Cite:CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
3U4I
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BU of 3u4i by Molmil
CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
Descriptor: ADP-ribosyl cyclase 1, Cyclic adenosine 5'-diphosphocarbocyclic ribose
Authors:Liu, Q, Hao, Q, Lee, H.C, Graeff, R.
Deposit date:2011-10-08
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.118 Å)
Cite:CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
1R12
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BU of 1r12 by Molmil
Native Aplysia ADP ribosyl cyclase
Descriptor: ADP-ribosyl cyclase
Authors:Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R0S
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BU of 1r0s by Molmil
Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant
Descriptor: ADP-ribosyl cyclase
Authors:Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
Deposit date:2003-09-22
Release date:2004-03-09
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R16
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BU of 1r16 by Molmil
Aplysia ADP ribosyl cyclase with bound pyridylcarbinol and R5P
Descriptor: 3-PYRIDINYLCARBINOL, ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE
Authors:Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R15
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Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P
Descriptor: ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, NICOTINAMIDE
Authors:Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
2I67
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BU of 2i67 by Molmil
Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase 1
Authors:Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
Deposit date:2006-08-28
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I66
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BU of 2i66 by Molmil
Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
Descriptor: ADP-ribosyl cyclase 1, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5S)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
Authors:Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
Deposit date:2006-08-28
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I65
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BU of 2i65 by Molmil
Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
Descriptor: ADP-ribosyl cyclase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
Deposit date:2006-08-28
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
3I9N
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BU of 3i9n by Molmil
Crystal structure of human CD38 complexed with an analog ribo-2'F-ADP ribose
Descriptor: ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Jiang, H, Zhang, B, Oppenheimer, N, Lin, H, Potter, B.V.L, Lee, H.C, Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9K
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BU of 3i9k by Molmil
Crystal structure of ADP ribosyl cyclase complexed with substrate NAD
Descriptor: ADP-ribosyl cyclase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Jiang, H, Zhang, B, Oppenheimer, N, Lin, H, Potter, B.V.L, Lee, H.C, Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9M
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BU of 3i9m by Molmil
Crystal structure of human CD38 complexed with an analog ara-2'F-ADPR
Descriptor: ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Jiang, H, Zhang, B, Oppenheimer, N, Lin, H, Potter, B.V.L, Lee, H.C, Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9L
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BU of 3i9l by Molmil
Crystal structure of ADP ribosyl cyclase complexed with N1-cIDPR
Descriptor: ADP-ribosyl cyclase, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Jiang, H, Zhang, B, Oppenheimer, N, Lin, H, Potter, B.V.L, Lee, H.C, Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9J
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BU of 3i9j by Molmil
Crystal structure of ADP ribosyl cyclase complexed with a substrate analog and a product nicotinamide
Descriptor: ADP-ribosyl cyclase, NICOTINAMIDE, Nicotinamide 2-fluoro-adenine dinucleotide, ...
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Jiang, H, Zhang, B, Oppenheimer, N, Lin, H, Potter, B.V.L, Lee, H.C, Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3ZWN
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BU of 3zwn by Molmil
Crystal structure of Aplysia cyclase complexed with substrate NGD and product cGDPR
Descriptor: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-RIBOSYL CYCLASE, CYCLIC GUANOSINE DIPHOSPHATE-RIBOSE
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWW
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BU of 3zww by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom
Descriptor: ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWM
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BU of 3zwm by Molmil
Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR
Descriptor: ADP-RIBOSYL CYLCASE, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWP
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BU of 3zwp by Molmil
Crystal structure of ADP ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.1 angstrom
Descriptor: ADP-RIBOSYL CYCLASE, GLYCEROL, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWV
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BU of 3zwv by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom
Descriptor: ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase.
J. Mol. Biol., 415, 2012
3ZWY
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BU of 3zwy by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose and cyclic 8-bromo-cyclic-ADP-ribose
Descriptor: (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published
3ZWO
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BU of 3zwo by Molmil
Crystal structure of ADP ribosyl cyclase complexed with reaction intermediate
Descriptor: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-RIBOSYL CYCLASE, GUANOSINE DIPHOSPHATE RIBOSE
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWX
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BU of 3zwx by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose
Descriptor: ADP-RIBOSYL CYCLASE, CHLORIDE ION, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published

 

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