2B0Y
| Solution Structure of a peptide mimetic of the fourth cytoplasmic loop of the G-protein coupled CB1 cannabinoid receptor | Descriptor: | Cannabinoid receptor 1 | Authors: | Grace, C.R, Cowsik, S.M, Shim, J.Y, Welsh, W.J, Howlett, A.C. | Deposit date: | 2005-09-15 | Release date: | 2006-08-29 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment. J.Struct.Biol., 159, 2007
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1U34
| 3D NMR structure of the first extracellular domain of CRFR-2beta, a type B1 G-protein coupled receptor | Descriptor: | Corticotropin releasing factor receptor 2 | Authors: | Grace, C.R, Perrin, M.H, DiGruccio, M.R, Miller, C.L, Rivier, J.E, Vale, W.W, Riek, R. | Deposit date: | 2004-07-20 | Release date: | 2004-09-07 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor Proc.Natl.Acad.Sci.USA, 101, 2004
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2N0W
| Mdmx-SJ212 | Descriptor: | 4-({(4S,5R)-4-(5-bromo-2-fluorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 | Authors: | Grace, C.R, Kriwacki, R.W. | Deposit date: | 2015-03-17 | Release date: | 2016-01-27 | Last modified: | 2016-05-04 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2N06
| Mdmx-298 | Descriptor: | 4-[[(4S,5R)-5-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, Protein Mdm4 | Authors: | Grace, C.R, Kriwacki, R.W. | Deposit date: | 2015-03-04 | Release date: | 2016-01-27 | Last modified: | 2019-11-06 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2N14
| Mdmx-295 | Descriptor: | 4-({(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 | Authors: | Grace, C.R, Kriwacki, R.W. | Deposit date: | 2015-03-20 | Release date: | 2016-01-27 | Last modified: | 2016-05-04 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2N0U
| Mdmx-057 | Descriptor: | 4-[(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-1-(3-oxidanylidenepiperazin-1-yl)carbonyl-4,5-dihydroimidazol-2-yl]-3-propan-2-yloxy-benzenecarbonitrile, Protein Mdm4 | Authors: | Grace, C.R, Kriwacki, R.W. | Deposit date: | 2015-03-17 | Release date: | 2016-01-27 | Last modified: | 2016-05-04 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2MWY
| Mdmx-p53 | Descriptor: | Cellular tumor antigen p53, Protein Mdm4 | Authors: | Grace, C.R. | Deposit date: | 2014-12-03 | Release date: | 2016-01-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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6CKV
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8UM1
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8UM2
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4PX9
| DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
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4PXA
| DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
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3RTR
| A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases | Descriptor: | Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION | Authors: | Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A. | Deposit date: | 2011-05-03 | Release date: | 2011-07-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases. Nat.Struct.Mol.Biol., 18, 2011
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2M5B
| The NMR structure of the BID-BAK complex | Descriptor: | Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB | Authors: | Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R. | Deposit date: | 2013-02-19 | Release date: | 2013-04-17 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | BID-induced structural changes in BAK promote apoptosis. Nat.Struct.Mol.Biol., 20, 2013
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2L27
| NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist | Descriptor: | Corticotropin-releasing factor receptor 1, peptide agonist | Authors: | Grace, C.R.R, Perrin, M.H, Gulyas, J.R.R, Rivier, J.E, Vale, W.W, Riek, R.R. | Deposit date: | 2010-08-12 | Release date: | 2010-09-01 | Last modified: | 2017-03-01 | Method: | SOLUTION NMR | Cite: | NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist. J.Biol.Chem., 285, 2010
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2RMI
| 3D NMR structure of astressin | Descriptor: | astressin | Authors: | Royappa, G.C.R, Cervini, L, Gulyas, J, Rivier, J, Riek, R. | Deposit date: | 2007-10-17 | Release date: | 2007-10-30 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide Biopolymers, 87, 2007
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4R2Y
| Crystal structure of APC11 RING domain | Descriptor: | Anaphase-promoting complex subunit 11, ZINC ION | Authors: | Brown, N.G, Watson, E.R, Weissmann, F, Jarvis, M.A, Vanderlinden, R, Grace, C.R.R, Frye, J.J, Dube, P, Qiao, R, Petzold, G, Cho, S.E, Alsharif, O, Bao, J, Zheng, J, Nourse, A, Kurinov, I, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2014-08-13 | Release date: | 2014-10-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.755 Å) | Cite: | Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly. Mol.Cell, 56, 2014
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6D74
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6MH9
| The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein A121I mutant to 2.02 Angstrom resolution | Descriptor: | Fatty Acid Kinase (Fak) B1 protein, PALMITIC ACID | Authors: | Cuypers, M.G, Ericson, M, Subramanian, C, White, S.W, Rock, C.O. | Deposit date: | 2018-09-17 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes. J.Biol.Chem., 298, 2022
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5JG6
| APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C | Descriptor: | Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION | Authors: | Brown, N.G, Zhang, W, Yu, S, Miller, D.J, Sidhu, S.S, Schulman, B.A. | Deposit date: | 2016-04-19 | Release date: | 2016-06-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.0013 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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4N8M
| Structural polymorphism in the N-terminal oligomerization domain of NPM1 | Descriptor: | COBALT (II) ION, Nucleophosmin | Authors: | Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W. | Deposit date: | 2013-10-17 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc.Natl.Acad.Sci.USA, 111, 2014
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4HNJ
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5L9U
| Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-11 | Release date: | 2016-09-14 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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5L9T
| Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-11 | Release date: | 2016-10-26 | Last modified: | 2016-11-02 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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3O6B
| A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB) low resolution | Descriptor: | Cell division control protein 53, Defective in cullin neddylation protein 1 | Authors: | Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A. | Deposit date: | 2010-07-28 | Release date: | 2010-09-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A dual E3 mechanism for Rub1 ligation to Cdc53. Mol.Cell, 39, 2010
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