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5O9M
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BU of 5o9m by Molmil
Crystal structure of human Histamine-Releasing Factor (HRF/TCTP)containing a disulphide-linked dimer
Descriptor: DI(HYDROXYETHYL)ETHER, Translationally-controlled tumor protein
Authors:Dore, K.A, Kashiwakura, J, McDonnell, J.M, Gould, H.J, Kawakami, T, Sutton, B.J, Davies, A.M.
Deposit date:2017-06-19
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.
Mol. Immunol., 93, 2017
5O9L
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BU of 5o9l by Molmil
Crystal structure of human Histamine-Releasing Factor (HRF/TCTP)
Descriptor: Translationally-controlled tumor protein
Authors:Dore, K.A, Kashiwakura, J, McDonnell, J.M, Gould, H.J, Kawakami, T, Sutton, B.J, Davies, A.M.
Deposit date:2017-06-19
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.
Mol. Immunol., 93, 2017
5O9K
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BU of 5o9k by Molmil
Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP)
Descriptor: GLYCEROL, Translationally-controlled tumor protein
Authors:Dore, K.A, Kashiwakura, J, McDonnell, J.M, Gould, H.J, Kawakami, T, Sutton, B.J, Davies, A.M.
Deposit date:2017-06-19
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.014 Å)
Cite:Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.
Mol. Immunol., 93, 2017
1G84
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BU of 1g84 by Molmil
THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE
Descriptor: IMMUNOGLOBULIN E
Authors:McDonnell, J.M, Cowburn, D, Gould, H.J, Sutton, B.J, Calvert, R, Beavil, R.E, Beavil, A.J, Henry, A.J.
Deposit date:2000-11-16
Release date:2001-05-16
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.
Nat.Struct.Biol., 8, 2001
5ANM
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BU of 5anm by Molmil
Crystal structure of IgE Fc in complex with a neutralizing antibody
Descriptor: IG EPSILON CHAIN C REGION, IMMUNOGLOBULIN G, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Cohen, E.S, Dobson, C.L, Kack, H, Wang, B, Sims, D.A, Lloyd, C.O, England, E, Rees, D.G, Guo, H, Karagiannis, S.N, O'Brien, S, Persdotter, S, Ekdahl, H, Butler, R, Keyes, F, Oakley, S, Carlsson, M, Briend, E, Wilkinson, T, Anderson, I.K, Monk, P.D, vonWachenfeldt, K, Eriksson, P.O, Gould, H.J, Vaughan, T.J, May, R.D.
Deposit date:2015-09-07
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A Novel Ige-Neutralizing Antibody for the Treatment of Severe Uncontrolled Asthma.
Mabs, 6, 2015
4B53
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Crystal structure of the isolated IgG4 CH3 domain
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
Authors:Davies, A.M, Rispens, T, den Bleker, T.H, McDonnell, J.M, Gould, H.J, Aalberse, R.C, Sutton, B.J.
Deposit date:2012-08-02
Release date:2012-12-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Human Igg4 C(H)3 Dimer Reveals the Role of Arg409 in the Mechanism of Fab-Arm Exchange.
Mol.Immunol., 54, 2012
4C55
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Crystal structure of serum-derived human IgG4 Fc
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, IG GAMMA-4 CHAIN C REGION, ...
Authors:Davies, A.M, Rispens, T, Ooijevaar-deHeer, P, Gould, H.J, Jefferis, R, Aalberse, R.C, Sutton, B.J.
Deposit date:2013-09-10
Release date:2013-11-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Determinants of Unique Properties of Human Igg4-Fc
J.Mol.Biol., 426, 2014
4C54
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Crystal structure of recombinant human IgG4 Fc
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Davies, A.M, Rispens, T, Ooijevaar-deHeer, P, Gould, H.J, Jefferis, R, Aalberse, R.C, Sutton, B.J.
Deposit date:2013-09-10
Release date:2013-11-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Determinants of Unique Properties of Human Igg4-Fc
J.Mol.Biol., 426, 2014
4BUH
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BU of 4buh by Molmil
Human IgE against the major allergen Bet v 1 - Crystal structure of clone M0418 scFv
Descriptor: 1,2-ETHANEDIOL, CLONE M0418 SCFV, DI(HYDROXYETHYL)ETHER
Authors:Davies, A.M, Levin, M, Lilljekvist, M, Carlsson, F, Gould, H.J, Sutton, B.J, Ohlin, M.
Deposit date:2013-06-20
Release date:2013-11-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Human Ige Against the Major Allergen Bet V 1 - Defining an Epitope with Limited Cross-Reactivity between Different Pr-10 Family Proteins
Clin.Exp.Allergy, 44, 2014
1T8C
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BU of 1t8c by Molmil
Structure of the C-type lectin domain of CD23
Descriptor: Low affinity immunoglobulin epsilon Fc receptor
Authors:Hibbert, R.G, Teriete, P, Grundy, G.J, Sutton, B.J, Gould, H.J, McDonnell, J.M.
Deposit date:2004-05-12
Release date:2005-07-26
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:The structure of human CD23 and its interactions with IgE and CD21
J.Exp.Med., 202, 2005
1T8D
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BU of 1t8d by Molmil
Structure of the C-type lectin domain of CD23
Descriptor: Low affinity immunoglobulin epsilon Fc receptor
Authors:Hibbert, R.G, Teriete, P, Grundy, G.J, Sutton, B.J, Gould, H.J, McDonnell, J.M.
Deposit date:2004-05-12
Release date:2005-07-26
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The structure of human CD23 and its interactions with IgE and CD21
J.Exp.Med., 202, 2005
6EYO
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BU of 6eyo by Molmil
Structure of extended IgE-Fc in complex with two anti-IgE Fabs
Descriptor: 8D6 Fab heavy chain, 8D6 Fab light chain, Immunoglobulin heavy constant epsilon, ...
Authors:Chen, J.B, Ramadani, F, Pang, M.O.Y, Beavil, R.L, Holdom, M.D, Mitropoulou, A.N, Beavil, A.J, Gould, H.J, Chang, T.W, Sutton, B.J, McDonnell, J.M, Davies, A.M.
Deposit date:2017-11-13
Release date:2018-08-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.
Sci Rep, 8, 2018
6EYN
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BU of 6eyn by Molmil
Structure of the 8D6 (anti-IgE) Fab
Descriptor: 1,2-ETHANEDIOL, 8D6 Fab heavy chain, 8D6 Fab light chain, ...
Authors:Chen, J.B, Ramadani, F, Pang, M.O.Y, Beavil, R.L, Holdom, M.D, Mitropoulou, A.N, Beavil, A.J, Gould, H.J, Chang, T.W, Sutton, B.J, McDonnell, J.M, Davies, A.M.
Deposit date:2017-11-13
Release date:2018-08-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.
Sci Rep, 8, 2018
1O0V
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BU of 1o0v by Molmil
The crystal structure of IgE Fc reveals an asymmetrically bent conformation
Descriptor: GLYCEROL, Immunoglobulin heavy chain epsilon-1, SULFATE ION, ...
Authors:Wan, T, Beavil, R.L, Fabiane, S.M, Beavil, A.J, Sohi, M.K, Keown, M, Young, R.J, Henry, A.J, Owens, R.J, Gould, H.J, Sutton, B.J.
Deposit date:2002-09-06
Release date:2002-09-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of IgE Fc reveals an asymmetrically bent conformation
NAT.IMMUNOL., 3, 2002
5OTJ
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BU of 5otj by Molmil
Monomeric polcalcin (Phl p 7) in complex with two identical allergen-specific antibodies
Descriptor: 1,2-ETHANEDIOL, 102.1F10 Fab heavy chain, 102.1F10 Fab light chain, ...
Authors:Mitropoulou, A.N, Davies, A.M, Beavil, A.J, McDonnell, J.M, Sutton, B.J.
Deposit date:2017-08-22
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8OJU
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BU of 8oju by Molmil
Crystal structure of the human IgD Fab - structure Fab3
Descriptor: 1,2-ETHANEDIOL, Human IgD Fab heavy chain, Human IgD Fab light chain, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023
8OJV
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BU of 8ojv by Molmil
Crystal structure of the human IgD Fab - structure Fab4
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023
8OJS
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BU of 8ojs by Molmil
Crystal structure of the human IgD Fab - structure Fab1
Descriptor: 1,2-ETHANEDIOL, Human IgD Fab heavy chain, Human IgD Fab light chain, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023
8OJT
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BU of 8ojt by Molmil
Crystal structure of the human IgD Fab - structure Fab2
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AZIDE ION, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023
8Q6K
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BU of 8q6k by Molmil
Human IgD Fab in complex with an orthosteric inhibitor of Phl p 7
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Human IgD Fab heavy chain, ...
Authors:Davies, A.M, Vester, S.K, McDonnell, J.M.
Deposit date:2023-08-11
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor.
Antibodies, 12, 2023
5LGJ
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BU of 5lgj by Molmil
THE CRYSTAL STRUCTURE OF IGE FC MUTANT - P333C
Descriptor: GLYCEROL, Ig epsilon chain C region, SULFATE ION, ...
Authors:Dhaliwal, B, Pang, M.O.Y, Sutton, B.J.
Deposit date:2016-07-07
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:THE CRYSTAL STRUCTURE OF IGE FC MUTANT - P333C
To Be Published
5LGK
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BU of 5lgk by Molmil
Crystal structure of the human IgE-Fc bound to its B cell receptor derCD23
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, ...
Authors:Dhaliwal, B, Pang, M.O.Y, Sutton, B.J.
Deposit date:2016-07-07
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:IgE binds asymmetrically to its B cell receptor CD23.
Sci Rep, 7, 2017
2WQR
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BU of 2wqr by Molmil
The high resolution crystal structure of IgE Fc
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, IG EPSILON CHAIN C REGION, ...
Authors:Dhaliwal, B, Sutton, B.J, Beavil, A.J.
Deposit date:2009-08-26
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011
2Y7Q
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BU of 2y7q by Molmil
THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA, IG EPSILON CHAIN C REGION, ...
Authors:Davies, A.M, Holdom, M.D, Nettleship, J.E, Beavil, A.J, Owens, R.J, Sutton, B.J.
Deposit date:2011-02-01
Release date:2011-04-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011
4EZM
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BU of 4ezm by Molmil
Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23
Descriptor: Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, alpha-D-mannopyranose, ...
Authors:Dhaliwal, B, Yuan, D, Sutton, B.J.
Deposit date:2012-05-03
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc{varepsilon}RI.
Proc.Natl.Acad.Sci.USA, 109, 2012

 

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