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4YT9
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CRYSTAL STRUCTURE OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE (PPAD) SUBSTRATE-UNBOUND.
Descriptor:Peptidylarginine deiminase, SODIUM ION, GLYCEROL
Authors:Goulas, T., Mizgalska, D., Garcia-Ferrer, I., Kantyka, T., Guevara, T., Szmigielski, B., Sroka, A., Millan, C., Uson, I., Veillard, F., Potempa, B., Mydel, P., Sola, M., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTB
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CRYSTAL STRUCTURE OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE (PPAD) IN COMPLEX WITH DIPEPTIDE ASP-GLN.
Descriptor:Peptidylarginine deiminase, SODIUM ION, ASPARTIC ACID, ...
Authors:Goulas, T., Mizgalska, D., Garcia-Ferrer, I., Kantyka, T., Guevara, T., Szmigielski, B., Sroka, A., Millan, C., Uson, I., Veillard, F., Potempa, B., Mydel, P., Sola, M., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTG
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CRYSTAL STRUCTURE OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE (PPAD) MUTANT C351A IN COMPLEX WITH DIPEPTIDE MET-ARG.
Descriptor:Peptidylarginine deiminase, SODIUM ION, CYSTEINE, ...
Authors:Goulas, T., Mizgalska, D., Garcia-Ferrer, I., Kantyka, T., Guevara, T., Szmigielski, B., Sroka, A., Millan, C., Uson, I., Veillard, F., Potempa, B., Mydel, P., Sola, M., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
3P24
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STRUCTURE OF PROFRAGILYSIN-3 FROM BACTEROIDES FRAGILIS
Descriptor:BFT-3, TETRAETHYLENE GLYCOL, GLYCEROL, ...
Authors:Goulas, T., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2010-10-01
Release date:2010-12-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog.
Proc.Natl.Acad.Sci.USA, 108, 2011
5CX8
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STRUCTURE OF RAGB, A MAJOR IMMUNODOMINANT VIRULENCE FACTOR OF PORPHYROMONAS GINGIVALIS.
Descriptor:Lipoprotein RagB, 3-deoxy-beta-D-ribo-hexopyranose, 6-O-phosphono-D-tagatose, ...
Authors:Goulas, T., Garcia-Ferrer, I., Hutcherson, J.A., Potempa, B.A., Potempa, J., Scott, D.A., Gomis-Ruth, F.X.
Deposit date:2015-07-28
Release date:2015-10-21
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis.
Mol Oral Microbiol, 31, 2016
5NCS
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STRUCTURE OF THE NATIVE SERPIN-TYPE PROTEINASE INHIBITOR, MIROPIN.
Descriptor:Serpin
Authors:Goulas, T., Ksiazek, M., Garcia-Ferrer, I., Mizgalska, D., Potempa, J., Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NCT
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STRUCTURE OF THE TRYPSIN INDUCED SERPIN-TYPE PROTEINASE INHIBITOR, MIROPIN.
Descriptor:Serpin-type proteinase inhibitor, miropin, ASPARTIC ACID, ...
Authors:Goulas, T., Ksiazek, M., Garcia-Ferrer, I., Mizgalska, D., Potempa, J., Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NCU
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STRUCTURE OF THE SUBTILISIN INDUCED SERPIN-TYPE PROTEINASE INHIBITOR, MIROPIN.
Descriptor:Serpin, POTASSIUM ION, IODIDE ION, ...
Authors:Goulas, T., Ksiazek, M., Garcia-Ferrer, I., Mizgalska, D., Potempa, J., Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NCW
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STRUCTURE OF THE TRYPSIN INDUCED SERPIN-TYPE PROTEINASE INHIBITOR, MIROPIN (V367K/K368A MUTANT).
Descriptor:Serpin-type proteinase inhibitor, miropin, ZINC ION, ...
Authors:Goulas, T., Ksiazek, M., Garcia-Ferrer, I., Mizgalska, D., Potempa, J., Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
6I0X
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PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEMINASE (PPAD) MUTANT G231N/E232T/N235D IN COMPLEX WITH CL-AMIDINE.
Descriptor:Peptidylarginine deiminase, SODIUM ION, N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE, ...
Authors:Gomis-Ruth, F.X., Goulas, T., Sola, M., Potempa, J.
Deposit date:2018-10-26
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure, function, and inhibition of a genomic/clinical variant of Porphyromonas gingivalis peptidylarginine deiminase.
Protein Sci., 28, 2019
4ACQ
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ALPHA-2 MACROGLOBULIN
Descriptor:ALPHA-2-MACROGLOBULIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Marrero, A., Duquerroy, S., Trapani, S., Goulas, T., Guevara, T., Andersen, G.R., Navaza, J., Sottrup-Jensen, L., Gomis-Ruth, F.X.
Deposit date:2011-12-17
Release date:2012-02-22
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:The crystal structure of human alpha 2-macroglobulin reveals a unique molecular cage.
Angew. Chem. Int. Ed. Engl., 51, 2012
5M11
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STRUCTURAL AND FUNCTIONAL PROBING OF PORZ, AN ESSENTIAL BACTERIAL SURFACE COMPONENT OF THE TYPE-IX SECRETION SYSTEM OF HUMAN ORAL-MICROBIOMIC PORPHYROMONAS GINGIVALIS.
Descriptor:Immunoreactive 84kD antigen PG93, CALCIUM ION, ZINC ION, ...
Authors:Lasica, A.M., Goulas, T., Mizgalska, D., Zhou, X., Ksiazek, M., Madej, M., Guo, Y., Guevara, T., Nowak, M., Potempa, B., Goel, A., Sztukowska, M., Prabhakar, A.T., Bzowska, M., Widziolek, M., Thogersen, I.B., Enghild, J.J., Simonian, M., Kulczyk, A.W., Nguyen, K.-A., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Sci Rep, 6, 2016
5MUN
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STRUCTURAL INSIGHT INTO ZYMOGENIC LATENCY OF GINGIPAIN K FROM PORPHYROMONAS GINGIVALIS.
Descriptor:Lys-gingipain W83, AZIDE ION
Authors:Pomowski, A., Uson, I., Nowakovska, Z., Veillard, F., Sztukowska, M.N., Guevara, T., Goulas, T., Mizgalska, D., Nowak, M., Potempa, B., Huntington, J.A., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
J. Biol. Chem., 292, 2017
6HT9
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MOUSE FETUIN-B IN COMPLEX WITH CRAYFISH ASTACIN
Descriptor:Astacin, Fetuin-B, ZINC ION, ...
Authors:Gomis-Ruth, F.X., Goulas, T., Guevara, T., Cuppari, A.
Deposit date:2018-10-03
Release date:2019-03-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition.
Iucrj, 6, 2019
4YU5
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CRYSTAL STRUCTURE OF SELENOMETHIONINE VARIANT OF BACILLUS ANTHRACIS IMMUNE INHIBITOR A2 PEPTIDASE ZYMOGEN
Descriptor:Immune inhibitor A, metalloprotease, ZINC ION, ...
Authors:Arolas, J.L., Goulas, T., Gomis-Ruth, F.X.
Deposit date:2015-03-18
Release date:2015-10-28
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome.
Structure, 24, 2016
4YU6
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CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS IMMUNE INHIBITOR A2 PEPTIDASE ZYMOGEN
Descriptor:Immune inhibitor A, metalloprotease, ZINC ION, ...
Authors:Arolas, J.L., Goulas, T., Gomis-Ruth, F.X.
Deposit date:2015-03-18
Release date:2015-10-28
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome.
Structure, 24, 2016
4ZIQ
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CRYSTAL STRUCTURE OF TRYPSIN ACTIVATED ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI.
Descriptor:Uncharacterized lipoprotein YfhM, GLYCEROL, CHLORIDE ION
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZIU
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CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING THE RESIDUES FROM DOMAIN MG7 TO THE C-TERMINUS.
Descriptor:Uncharacterized lipoprotein YfhM, NICKEL (II) ION, GLYCEROL
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZJG
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CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING DOMAINS MG0-NIE-MG1.
Descriptor:alpha-2-Macroglobulin, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ...
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, X.F.
Deposit date:2015-04-29
Release date:2015-06-10
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZJH
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CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING DOMAINS NIE-MG1.
Descriptor:alpha-2-Macroglobulin, ACETATE ION, GLYCEROL
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, X.F.
Deposit date:2015-04-29
Release date:2015-06-10
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
5A42
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CRYO-EM SINGLE PARTICLE 3D RECONSTRUCTION OF THE NATIVE CONFORMATION OF E. COLI ALPHA-2-MACROGLOBULIN (ECAM)
Descriptor:UNCHARACTERIZED LIPOPROTEIN YFHM
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, F.X.
Deposit date:2015-06-04
Release date:2015-07-29
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (16 Å)
Cite:Structural and Functional Insights Into Escherichia Coli Alpha2- Macroglobulin Endopeptidase Snap-Trap Inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
5NV6
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STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR BETA-INDUCED PROTEIN (TGFBIP).
Descriptor:Transforming growth factor-beta-induced protein ig-h3, ACETATE ION
Authors:Garcia-Castellanos, R., Nielsen, S.N., Runager, K., Thogersen, B.I., Goulas, T., Enghild, J.J., Gomis-Ruth, F.X.
Deposit date:2017-05-03
Release date:2017-08-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural and Functional Implications of Human Transforming Growth Factor beta-Induced Protein, TGFBIp, in Corneal Dystrophies.
Structure, 25, 2017
6HPV
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CRYSTAL STRUCTURE OF MOUSE FETUIN-B
Descriptor:Fetuin-B, N-ACETYL-D-GLUCOSAMINE, ACETATE ION
Authors:Fahrenkamp, D., Dietzel, E., de Sanctis, D., Jovine, L.
Deposit date:2018-09-22
Release date:2019-02-20
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition.
Iucrj, 6, 2019
6I9A
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PORPHYROMONAS GINGIVALIS GINGIPAIN K (KGP) IN COMPLEX WITH INHIBITOR KYT-36
Descriptor:Lys-gingipain W83, UNKNOWN ATOM OR ION, SODIUM ION, ...
Authors:Gomis-Ruth, F.X., Guevara, T., Rofdriguez-Banqueri, A.
Deposit date:2018-11-22
Release date:2019-03-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.
Sci Rep, 9, 2019