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5KCD
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN N-METHYL SUBSTITUTED OBHS-N DERIVATIVE
Descriptor:Estrogen receptor, NCOA2, (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-methyl-N-phenyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Zhou, H.B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B.S., Griffin, P.R., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-06-06
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5KCE
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN N-METHYL, 2-CHLOROBENZYL OBHS-N DERIVATIVE
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, (1S,2R,4S)-N-(2-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-methyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Zhou, H.B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B.S., Griffin, P.R., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-06-06
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.847 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5KCF
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN N-ETHYL, 4-METHOXYBENZYL OBHS-N DERIVATIVE
Descriptor:Estrogen receptor, NCOA2, (1R,2S,4R)-N-ethyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, ...
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Zhou, H.B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B.S., Griffin, P.R., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-06-06
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5KCT
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN N-ETHYL, 4-CHLOROBENZYL OBHS-N DERIVATIVE
Descriptor:Estrogen receptor, NCOA2, (1R,2S,4R)-N-(4-chlorophenyl)-N-ethyl-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, ...
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Zhou, H.B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B.S., Griffin, P.R., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-06-07
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5KCU
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN N-ETHYL, ALPHA-NAPHTHYL OBHS-N DERIVATIVE
Descriptor:Estrogen receptor, NCOA2, (1S,2R,4S)-N-ethyl-5,6-bis(4-hydroxyphenyl)-N-(naphthalen-2-yl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Zhou, H.B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B.S., Griffin, P.R., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-06-07
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5KCW
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN N-TRIFLUOROETHYL OBHS-N DERIVATIVE
Descriptor:Estrogen receptor, NCOA2, (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-phenyl-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Zhou, H.B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B.S., Griffin, P.R., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-06-07
Release date:2016-11-16
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5KD9
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN N-TRIFLUOROETHYL 4-CHLOROBENZYL OBHS-N DERIVATIVE
Descriptor:Estrogen receptor, NCOA2, (1S,2R,4S)-N-(4-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Zhou, H.B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B.S., Griffin, P.R., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-06-07
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5W0P
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN DETERMINED BY X-RAY FREE ELECTRON LASER
Descriptor:Endolysin,Rhodopsin,S-arrestin, N-ACETYL-D-GLUCOSAMINE
Authors:Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., Xu, H.E.
Deposit date:2017-05-31
Release date:2017-08-09
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (3.013 Å)
Cite:Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell, 170, 2017
4LKP
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CRYSTAL STRUCTURE OF APO HUMAN EPIDERMAL FATTY ACID BINDING PROTEIN (FABP5)
Descriptor:Fatty acid-binding protein, epidermal, CHLORIDE ION, ...
Authors:Armstrong, E.H., Ortlund, E.A.
Deposit date:2013-07-08
Release date:2014-03-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta / delta (FABP5-PPAR beta / delta ) signaling pathway.
J.Biol.Chem., 289, 2014
4LKT
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CRYSTAL STRUCTURE OF HUMAN EPIDERMAL FATTY ACID BINDING PROTEIN (FABP5) IN COMPLEX WITH LINOLEIC ACID
Descriptor:Fatty acid-binding protein, epidermal, LINOLEIC ACID, ...
Authors:Armstrong, E.H., Ortlund, E.A.
Deposit date:2013-07-08
Release date:2014-03-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta / delta (FABP5-PPAR beta / delta ) signaling pathway.
J.Biol.Chem., 289, 2014
5KCC
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH OXABICYCLIC HEPTENE SULFONAMIDE (OBHS-N)
Descriptor:Estrogen receptor, NCOA2, (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-phenyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide
Authors:Nwachukwu, J.C., Srinivasan, S., Zheng, Y., Wang, S., Min, J., Dong, C., Liao, Z., Cavett, V., Nowak, J., Houtman, R., Carlson, K.E., Josan, J.S., Elemento, O., Katzenellenbogen, J.A., Zhou, H.B., Nettles, K.W.
Deposit date:2016-06-06
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.386 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5L11
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HUMAN LIVER RECEPTOR HOMOLOGUE-1 (LRH-1) BOUND TO RJW100 AND A FRAGMENT OF TIF-2
Descriptor:Nuclear receptor subfamily 5 group A member 2, Tif2, (1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol
Authors:Mays, S.G., Ortlund, E.A.
Deposit date:2016-07-28
Release date:2016-10-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
J. Biol. Chem., 291, 2016
5SYZ
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HUMAN LIVER RECEPTOR HOMOLOGUE-1 (LRH-1) BOUND TO A RJW100 STEREOISOMER AND A FRAGMENT OF TIF-2
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, (1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol
Authors:Ortlund, E.A., Mays, S.G.
Deposit date:2016-08-12
Release date:2016-10-12
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.9261 Å)
Cite:Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
J. Biol. Chem., 291, 2016