Author results

1BIX
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THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES
Descriptor:AP ENDONUCLEASE 1, SAMARIUM (III) ION, PLATINUM (II) ION
Authors:Gorman, M.A., Morera, S., Rothwell, D.G., De La Fortelle, E., Mol, C.D., Tainer, J.A., Hickson, I.D., Freemont, P.S.
Deposit date:1998-06-19
Release date:1999-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
EMBO J., 16, 1997
3HA4
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CRYSTAL STRUCTURE OF THE TYPE ONE MEMBRANE PROTEIN MIX1 FROM LEISHMANIA
Descriptor:MIX1, CARBONATE ION
Authors:Gorman, M.A., Walsh, P.J., Parker, M.W.
Deposit date:2009-05-01
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Leishmania major MIX protein: A scaffold protein that mediates protein-protein interactions.
Protein Sci., 20, 2011
4ONI
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STRUCTURE OF HUMAN ORPHAN RECEPTOR LRH1 BOUND TO TWO BACTERIAL PHOSPHOLIPIDS
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor subfamily 0 group B member 2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Gorman, M.A., Parker, M.W., Kusumo, S.
Deposit date:2014-01-28
Release date:2015-02-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human nuclear receptor LRH1 bound to phosopholipids and SHP peptide
To be Published
4TKX
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STRUCTURE OF PROTEASE
Descriptor:Lys-gingipain W83, SULFATE ION, SODIUM ION, ...
Authors:Gorman, M.A., Parker, M.W.
Deposit date:2014-05-28
Release date:2014-12-31
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health.
Protein Sci., 24, 2015
3VFL
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STRUCTURE, FUNCTION, STABILITY AND KNOCKOUT PHENOTYPE OF DIHYDRODIPICOLINATE SYNTHASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Dihydrodipicolinate synthase, POTASSIUM ION, GLYCEROL, ...
Authors:Gorman, M.A.
Deposit date:2012-01-10
Release date:2013-06-12
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure, Function, Stability and Knockout Phenotype of Dihydrodipicolinate Synthase from Streptococcus pneumoniae
To be Published
2R5G
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STRUCTURE OF HUMAN CLIC2, CRYSTAL FORM B
Descriptor:Chloride intracellular channel protein 2
Authors:Gorman, M.A., Hansen, G., Cromer, B.A., Parker, M.W.
Deposit date:2007-09-03
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
5VP3
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LIGHT-SENSITIVE PHOTOPROTEIN
Descriptor:Mnemiopsin 1, CADMIUM ION, NICKEL (II) ION, ...
Authors:Gorman, M.A., Parker, M.W.
Deposit date:2017-05-04
Release date:2018-05-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations.
J. Biol. Chem., 294, 2019
4FHA
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STRUCTURE OF DIHYDRODIPICOLINATE SYNTHASE FROM STREPTOCOCCUS PNEUMONIAE,BOUND TO PYRUVATE AND LYSINE
Descriptor:Dihydrodipicolinate synthase, LYSINE, SODIUM ION
Authors:Perugini, M.A., Dogovski, C., Parker, M.W., Gorman, M.A.
Deposit date:2012-06-06
Release date:2013-09-18
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure, Function, Stability and Knockout Phenotype of Dihydrodipicolinate Synthase from Streptococcus pneumoniae
To be Published
1E32
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STRUCTURE OF THE N-TERMINAL DOMAIN AND THE D1 AAA DOMAIN OF MEMBRANE FUSION ATPASE P97
Descriptor:P97, ADENOSINE-5'-DIPHOSPHATE
Authors:Zhang, X., Shaw, A., Bates, P.A., Gorman, M.A., Kondo, H., Dokurno, P., Leonard M, G., Sternberg, J.E., Freemont, P.S.
Deposit date:2000-06-05
Release date:2001-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Aaa ATPase P97
Mol.Cell, 6, 2000
2BSK
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CRYSTAL STRUCTURE OF THE TIM9 TIM10 HEXAMERIC COMPLEX
Descriptor:MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9 A, MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10
Authors:Webb, C.T., Gorman, M.A., Lazarus, M., Ryan, M.T., Gulbis, J.M.
Deposit date:2005-05-23
Release date:2006-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structure of the Mitochondrial Chaperone Tim910 Reveals a Six-Bladed Alpha-Propeller.
Mol.Cell, 21, 2006
2R4V
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STRUCTURE OF HUMAN CLIC2, CRYSTAL FORM A
Descriptor:Chloride intracellular channel protein 2, GLUTATHIONE
Authors:Hansen, G., Cromer, B.A., Gorman, M.A., Parker, M.W.
Deposit date:2007-09-02
Release date:2007-11-13
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
4Y0G
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BETA2 CARBOHYDRATE BINDING MODULE (CBM) OF AMP-ACTIVATED PROTEIN KINASE (AMPK)
Descriptor:5'-AMP-activated protein kinase subunit beta-2, GLYCEROL
Authors:Mobbs, J., Gorman, M.A., Parker, M.W., Gooley, P.R., Griffin, M.
Deposit date:2015-02-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.
Biochem.J., 468, 2015
4YEE
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BETA2 CARBOHYDRATE BINDING MODULE (CBM) OF AMP-ACTIVATED PROTEIN KINASE (AMPK) IN COMPLEX WITH GLUCOSYL-BETA-CYCLODEXTRIN
Descriptor:5'-AMP-activated protein kinase subunit beta-2, GLYCEROL, 6-O-alpha-D-Glucosyl-beta-cyclodextrin
Authors:Mobbs, J., Gorman, M.A., Parker, M.W., Gooley, P.R., Griffin, M.
Deposit date:2015-02-24
Release date:2015-04-01
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.
Biochem.J., 468, 2015
4YEF
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BETA1 CARBOHYDRATE BINDING MODULE (CBM) OF AMP-ACTIVATED PROTEIN KINASE (AMPK) IN COMPLEX WITH GLUCOSYL-BETA-CYCLODODEXTRIN
Descriptor:5'-AMP-activated protein kinase subunit beta-1, 6-O-alpha-D-Glucosyl-beta-cyclodextrin, GLYCEROL, ...
Authors:Mobbs, J., Gorman, M.A., Parker, M.W., Gooley, P.R., Griffin, M.
Deposit date:2015-02-24
Release date:2015-06-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.
Biochem.J., 468, 2015
4ZHX
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NOVEL BINDING SITE FOR ALLOSTERIC ACTIVATION OF AMPK
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Langendorf, C.G., Ngoei, K.R., Issa, S.M.A., Ling, N., Gorman, M.A., Parker, M.W., Sakamoto, K., Scott, J.W., Oakhill, J.S., Kemp, B.E.
Deposit date:2015-04-27
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
Nat Commun, 7, 2016
5DHL
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CRYSTAL STRUCTURE OF TOXIN, MUTANT N197W
Descriptor:Perfringolysin O, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Parker, M.W., Gorman, M.A., Lawrence, S.L.
Deposit date:2015-08-31
Release date:2016-11-09
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structure of mutant toxin
To Be Published
5DIM
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MUTANT TOXIN IN 'NATIVE' SPACE GROUP
Descriptor:Perfringolysin O, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Parker, M.W., Gorman, M.A., Lawrence, S.L.
Deposit date:2015-09-01
Release date:2016-11-09
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structure of mutant toxin at 3.32 Angstrom resolution
To Be Published
1POS
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CRYSTAL STRUCTURE OF A NOVEL DISULFIDE-LINKED "TREFOIL" MOTIF FOUND IN A LARGE FAMILY OF PUTATIVE GROWTH FACTORS
Descriptor:PORCINE PANCREATIC SPASMOLYTIC POLYPEPTIDE
Authors:De, A., Brown, D., Gorman, M., Carr, M., Sanderson, M.R., Freemont, P.S.
Deposit date:1993-10-08
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.
Proc.Natl.Acad.Sci.USA, 91, 1994
4NKQ
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STRUCTURE OF A CYTOKINE RECEPTOR COMPLEX
Descriptor:Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, ...
Authors:Parker, M.W., Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4RS1
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CRYSTAL STRUCTURE OF RECEPTOR-CYTOKINE COMPLEX
Descriptor:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, Granulocyte-macrophage colony-stimulating factor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W., Dhagat, U.
Deposit date:2014-11-06
Release date:2015-11-11
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4ZGH
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STRUCTURE OF SUGAR BINDING PROTEIN PNEUMOLYSIN
Descriptor:Pneumolysin, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Parker, M.W., Feil, S.C., Morton, C.
Deposit date:2015-04-23
Release date:2016-03-09
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Sci Rep, 5, 2015
5BUO
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A RECEPTOR MOLECULE
Descriptor:Amyloid beta A4 protein, ZINC ION, CALCIUM ION, ...
Authors:Gao, C., Crespi, G.A.N., Gorman, M.A., Nero, T.L., Parker, M.W., Miles, L.A.
Deposit date:2015-06-04
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:NULL
To Be Published
5EZV
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X-RAY CRYSTAL STRUCTURE OF AMP-ACTIVATED PROTEIN KINASE ALPHA-2/ALPHA-1 RIM CHIMAERA (ALPHA-2(1-347)/ALPHA-1(349-401)/ALPHA-2(397-END) BETA-1 GAMMA-1) CO-CRYSTALLIZED WITH C2 (5-(5-HYDROXYL-ISOXAZOL-3-YL)-FURAN-2-PHOSPHONIC ACID)
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-2/alpha-1 RIM SWAP chimera, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Langendorf, C.G., Kemp, B.E.
Deposit date:2015-11-26
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
Nat Commun, 7, 2016
5IMT
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TOXIN RECEPTOR COMPLEX
Descriptor:Intermedilysin, CD59 glycoprotein, TRIETHYLENE GLYCOL, ...
Authors:Morton, C.J., Lawrence, S.L., Feil, S.C., Parker, M.W.
Deposit date:2016-03-06
Release date:2016-08-24
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.7001 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
5IMW
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TRAPPED TOXIN
Descriptor:Intermedilysin
Authors:Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W.
Deposit date:2016-03-07
Release date:2016-08-24
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
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