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Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution
Descriptor:	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ...
Authors:	Borodovsky, A, Wang, Y, Deng, N, Ye, M, Stephen, T.L, Goodwin, K, Goodwin, R, Strittmatter, N, Shaw, J, Sachsenmeier, K, Clarke, J.D, Hay, C, Reimer, C, Andrews, S.P, Brown, G.A, Congreve, M, Cheng, R.K.Y, Dore, A.S, Mason, J.S, Marshall, F.H, Weir, M.P, Lyne, P, Woessner, R.
Deposit date:	2018-06-15
Release date:	2019-06-26
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity J Immunother Cancer, 2020

Human JAK1 kinase in complex with compound 30 at 2.30 Angstroms resolution
Descriptor:	6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine, DI(HYDROXYETHYL)ETHER, Tyrosine-protein kinase JAK1
Authors:	Ferguson, A.D.
Deposit date:	2015-09-29
Release date:	2015-11-25
Last modified:	2015-12-30
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Identification of azabenzimidazoles as potent JAK1 selective inhibitors. Bioorg.Med.Chem.Lett., 26, 2016