Author results

1K1Q
  • Download 1k1q
  • View 1k1q
Molmil generated image of 1k1q
CRYSTAL STRUCTURE OF A DINB FAMILY ERROR PRONE DNA POLYMERASE FROM SULFOLOBUS SOLFATARICUS
Descriptor:DBH protein
Authors:Silvian, L.F., Toth, E.A., Pham, P., Goodman, M.F., Ellenberger, T.
Deposit date:2001-09-25
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
Nat.Struct.Biol., 8, 2001
1K1S
  • Download 1k1s
  • View 1k1s
Molmil generated image of 1k1s
CRYSTAL STRUCTURE OF DINB FROM SULFOLOBUS SOLFATARICUS
Descriptor:DBH protein
Authors:Silvian, L.F., Toth, E.A., Pham, P., Goodman, M.F., Ellenberger, T.
Deposit date:2001-09-25
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
Nat.Struct.Biol., 8, 2001
1Q8I
  • Download 1q8i
  • View 1q8i
Molmil generated image of 1q8i
CRYSTAL STRUCTURE OF ESCHERICHIA COLI DNA POLYMERASE II
Descriptor:DNA polymerase II
Authors:Brunzelle, J.S., Muchmore, C.R.A., Mashhoon, N., Blair-Johnson, M., Shuvalova, L., Goodman, M.F., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2003-08-21
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Escherichia Coli DNA Polymerase II
To be Published
3JPN
  • Download 3jpn
  • View 3jpn
Molmil generated image of 3jpn
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-DICHLORO METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPO
  • Download 3jpo
  • View 3jpo
Molmil generated image of 3jpo
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOCHLOROMETHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPP
  • Download 3jpp
  • View 3jpp
Molmil generated image of 3jpp
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOMETHYL METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPQ
  • Download 3jpq
  • View 3jpq
Molmil generated image of 3jpq
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOBROMO METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPR
  • Download 3jpr
  • View 3jpr
Molmil generated image of 3jpr
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-DIMETHYL METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPS
  • Download 3jps
  • View 3jps
Molmil generated image of 3jps
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-FLUORO METHYL METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPT
  • Download 3jpt
  • View 3jpt
Molmil generated image of 3jpt
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-FLUORO CHLORO METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3LK9
  • Download 3lk9
  • View 3lk9
Molmil generated image of 3lk9
DNA POLYMERASE BETA WITH A GAPPED DNA SUBSTRATE AND DTMP(CF2)P(CF2)P
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Zibinsky, M., Surya Prakash, G.K., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertell, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Wilson, S.H.
Deposit date:2010-01-27
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid.
Proc.Natl.Acad.Sci.USA, 107, 2010
3TFR
  • Download 3tfr
  • View 3tfr
Molmil generated image of 3tfr
TERNARY COMPLEX STRUCTURE OF DNA POLYMERASE BETA WITH A GAPPED DNA SUBSTRATE AND A, B DAMP(CF2)PP IN THE ACTIVE SITE
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Chamberlain, B.T., Batra, V.K., Beard, W.A., Kadina, A.P., Shock, D.D., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Wilson, S.H.
Deposit date:2011-08-16
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Stereospecific Formation of a Ternary Complex of (S)-alpha, beta-Fluoromethylene-dATP with DNA Pol beta.
Chembiochem, 13, 2012
3TFS
  • Download 3tfs
  • View 3tfs
Molmil generated image of 3tfs
TERNARY COMPLEX STRUCTURE OF DNA POLYMERASE BETA WITH A GAPPED DNA SUBSTRATE AND A, B DAMP(CFH)PP IN THE ACTIVE SITE: STEREOSELECTIVE BINDING OF (S) ISOMER
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Chamberlain, B.T., Batra, V.K., Beard, W.A., Kadina, A.P., Shock, D.D., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Wilson, S.H.
Deposit date:2011-08-16
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Stereospecific Formation of a Ternary Complex of (S)-alpha, beta-Fluoromethylene-dATP with DNA Pol beta.
Chembiochem, 13, 2012
5JJ4
  • Download 5jj4
  • View 5jj4
Molmil generated image of 5jj4
CRYSTAL STRUCTURE OF A VARIANT HUMAN ACTIVATION-INDUCED DEOXYCYTIDINE DEAMINASE AS AN MBP FUSION PROTEIN
Descriptor:Maltose-binding periplasmic protein,Single-stranded DNA cytosine deaminase, ZINC ION, CALCIUM ION, ...
Authors:Pedersen, L.C., Goodman, M.F., Pham, P., Afif, S.A.
Deposit date:2016-04-22
Release date:2016-06-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.
DNA Repair (Amst.), 43, 2016
2NYT
  • Download 2nyt
  • View 2nyt
Molmil generated image of 2nyt
THE APOBEC2 CRYSTAL STRUCTURE AND FUNCTIONAL IMPLICATIONS FOR AID
Descriptor:Probable C->U-editing enzyme APOBEC-2, ZINC ION
Authors:Prochnow, C., Bransteitter, R., Klein, M., Goodman, M., Chen, X.
Deposit date:2006-11-21
Release date:2007-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The APOBEC-2 crystal structure and functional implications for the deaminase AID.
Nature, 445, 2007
3E1U
  • Download 3e1u
  • View 3e1u
Molmil generated image of 3e1u
THE CRYSTAL STRUCTURE OF THE ANTI-VIRAL APOBEC3G CATALYTIC DOMAIN
Descriptor:DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Holden, L., Prochnow, C., Chang, Y.P., Bransteitter, R., Chelico, L., Sen, U., Stevens, R.C., Goodman, R.F., Chen, X.S.
Deposit date:2008-08-04
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.
Nature, 456, 2008
3IQS
  • Download 3iqs
  • View 3iqs
Molmil generated image of 3iqs
CRYSTAL STRUCTURE OF THE ANTI-VIRAL APOBEC3G CATALYTIC DOMAIN
Descriptor:DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Holden, L.G., Prochnow, C., Chang, Y.P., Bransteitter, R., Chelico, L., Sen, U., Stevens, R.C., Goodman, R.F., Chen, X.S.
Deposit date:2009-08-20
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.
Nature, 456, 2008
2ISO
  • Download 2iso
  • View 2iso
Molmil generated image of 2iso
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-DIFLUOROMETHYLENE TRIPHOSPHATE
Descriptor:5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Sucato, C.A., Upton, T.G., Kashemirov, B.A., Martinek, V., Xiang, Y., Beard, W.A.
Deposit date:2006-10-18
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta.
Biochemistry, 46, 2007
2ISP
  • Download 2isp
  • View 2isp
Molmil generated image of 2isp
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-METHYLENE TRIPHOSPHATE
Descriptor:5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Sucato, C.A., Upton, T.G., Kashemirov, B.A., Martinek, V., Xiang, Y., Beard, W.A.
Deposit date:2006-10-18
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta.
Biochemistry, 46, 2007
2PXI
  • Download 2pxi
  • View 2pxi
Molmil generated image of 2pxi
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOFLUOROMETHYLENE TRIPHOSPHATE
Descriptor:5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:McKenna, C.E., Batra, V.K., Beard, W.A., Pedersen, L.C., Wilson, S.H.
Deposit date:2007-05-14
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta.
J.Am.Chem.Soc., 129, 2007
3GDX
  • Download 3gdx
  • View 3gdx
Molmil generated image of 3gdx
DNA POLYMERASE BETA WITH A GAPPED DND SUBSTRATE AND DTMP(CF2)PP
Descriptor:DNA polymerase beta, 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', ...
Authors:Wilson, S.H., Batra, V.K., Pedersen, L.C.
Deposit date:2009-02-24
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function
Org.Lett., 11, 2009
4DO9
  • Download 4do9
  • View 4do9
Molmil generated image of 4do9
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOFLUOROMETHYLENE TRIPHOSPHATE: STEREOSELECTIVE BINDING OF R-ISOMER
Descriptor:DNA polymerase beta, C C G A C C G C G C A T C A G C, G C T G A T G C G (DOC), ...
Authors:Batra, V.K.
Deposit date:2012-02-09
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Beta,gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
J.Am.Chem.Soc., 134, 2012
4DOA
  • Download 4doa
  • View 4doa
Molmil generated image of 4doa
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOFLUOROMETHYLENE TRIPHOSPHATE: NON-INTERACTIVE BINDING OF S-ISOMER
Descriptor:DNA polymerase beta, C C G A C C G C G C A T C A G C, G C T G A T G C G (DOC), ...
Authors:Batra, V.K.
Deposit date:2012-02-09
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.051 Å)
Cite:Beta,gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
J.Am.Chem.Soc., 134, 2012
4DOB
  • Download 4dob
  • View 4dob
Molmil generated image of 4dob
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOCHLOROROMETHYLENE TRIPHOSPHATE: STEREOSELECTIVE BINDING OF R-ISOMER
Descriptor:DNA polymerase beta, C C G A C C G C G C A T C A G C, G C T G A T G C G (DOC), ...
Authors:Batra, V.K.
Deposit date:2012-02-09
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Beta,Gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
J.Am.Chem.Soc., 134, 2012
4DOC
  • Download 4doc
  • View 4doc
Molmil generated image of 4doc
TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOCHLOROROMETHYLENE TRIPHOSPHATE:BINDING OF S-ISOMER
Descriptor:DNA polymerase beta, C C G A C C G C G C A T C A G C, G C T G A T G C G (DOC), ...
Authors:Batra, V.K.
Deposit date:2012-02-09
Release date:2012-06-13
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Beta,gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
J.Am.Chem.Soc., 134, 2012
<123>