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1C5G
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BU of 1c5g by Molmil
PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Goldsmith, E.J.
Deposit date:1999-12-07
Release date:1999-12-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition.
Nat.Struct.Biol., 2, 1995
7UOS
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BU of 7uos by Molmil
Structure of WNK1 inhibitor complex
Descriptor: 1,2-ETHANEDIOL, 4-[bromo(dichloro)methanesulfonyl]-N-cyclohexyl-2-nitroaniline, Serine/threonine-protein kinase WNK1
Authors:Akella, R, Goldsmith, E.J, Akella, R.
Deposit date:2022-04-13
Release date:2023-04-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of WNK1 inhibitor complex
To Be Published
5W7T
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BU of 5w7t by Molmil
STRUCTURE OF PHOSPHORYLATED WNK1
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase WNK1
Authors:JIOU, J, CHLEBOWICZ, J, AKELLA, R, GOLDSMITH, E.J.
Deposit date:2017-06-20
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:STRUCTURE OF PHOSPHORYLATED WNK1
To Be Published
1GOL
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BU of 1gol by Molmil
COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, EXTRACELLULAR REGULATED KINASE 2, MAGNESIUM ION
Authors:Harkins, P.C, Zhang, F, Goldsmith, E.J.
Deposit date:1996-01-23
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry, 35, 1996
8EDH
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BU of 8edh by Molmil
Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
Descriptor: Serine/threonine-protein kinase WNK3, ethyl 1-(5,7-dimethoxy-4-methylquinolin-2-yl)piperidine-4-carboxylate
Authors:Akella, R, Goldsmith, E.J.
Deposit date:2022-09-04
Release date:2023-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.111 Å)
Cite:Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening.
Drug Des Devel Ther, 17, 2023
5UOJ
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BU of 5uoj by Molmil
THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION
Descriptor: Mitogen-activated protein kinase 14
Authors:CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J.
Deposit date:2017-01-31
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.
Proc. Natl. Acad. Sci. U.S.A., 94, 1997
5UMO
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BU of 5umo by Molmil
STRUCTURE OF EXTRACELLULAR SIGNAL-REGULATED KINASE
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION
Authors:CHLEBOWICZ, J, ZHANG, F, GOLDSMITH, E.J.
Deposit date:2017-01-27
Release date:2017-03-01
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
Nature, 367, 1994
6OL2
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BU of 6ol2 by Molmil
Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening
Descriptor: ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ...
Authors:Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J.
Deposit date:2019-04-15
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening
To Be Published
6OTS
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BU of 6ots by Molmil
Rat ERK2 E320K
Descriptor: Mitogen-activated protein kinase 1
Authors:Taylor, C.A, Cormier, K.W, Juang, Y.-C, Goldsmith, E.J, Cobb, M.H.
Deposit date:2019-05-03
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
1A9U
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BU of 1a9u by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580
Descriptor: 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, MAP KINASE P38
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-04-10
Release date:1999-04-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
6OT6
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BU of 6ot6 by Molmil
Rat ERK2 D319N
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION
Authors:Taylor, C.A, Goldsmith, E.J, Cobb, M.H.
Deposit date:2019-05-02
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
2ERK
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BU of 2erk by Molmil
PHOSPHORYLATED MAP KINASE ERK2
Descriptor: EXTRACELLULAR SIGNAL-REGULATED KINASE 2
Authors:Canagarajah, B.J, Goldsmith, E.J.
Deposit date:1997-06-26
Release date:1998-07-01
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.
Cell(Cambridge,Mass.), 90, 1997
6CN9
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BU of 6cn9 by Molmil
Crystal structure of the Kinase domain of WNK1
Descriptor: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase WNK1
Authors:Akella, R, Goldsmith, E.J.
Deposit date:2018-03-07
Release date:2019-03-27
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Structure, 12, 2004
1BMK
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BU of 1bmk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655
Descriptor: 4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL6
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BU of 1bl6 by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995
Descriptor: 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-11
Release date:1999-07-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL7
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BU of 1bl7 by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025
Descriptor: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
5D9H
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BU of 5d9h by Molmil
Crystal structure of SPAK (STK39) dimer in the basal activity state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, STE20/SPS1-related proline-alanine-rich protein kinase, ...
Authors:Taylor, C.A, Juang, Y.C, Goldsmith, E.J, Cobb, M.H.
Deposit date:2015-08-18
Release date:2015-09-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Biochemistry, 54, 2015
3DAK
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BU of 3dak by Molmil
Crystal Structure of Domain-Swapped OSR1 kinase domain
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase OSR1
Authors:Lee, S, Cobb, M.H, Goldsmith, E.J.
Deposit date:2008-05-29
Release date:2009-02-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of domain-swapped STE20 OSR1 kinase domain.
Protein Sci., 18, 2008
3ENM
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BU of 3enm by Molmil
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
Descriptor: 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 6, GLYCEROL, ...
Authors:Min, X, Akella, R, He, H, Humphreys, J.M, Tsutakawa, S, Lee, S.-J, Tainer, J.A, Cobb, M.H, Goldsmith, E.J.
Deposit date:2008-09-25
Release date:2009-03-03
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
Structure, 17, 2009
3ERK
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BU of 3erk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025
Descriptor: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, EXTRACELLULAR REGULATED KINASE 2
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-09
Release date:1999-07-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
2GCD
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BU of 2gcd by Molmil
TAO2 kinase domain-staurosporine structure
Descriptor: STAUROSPORINE, Serine/threonine-protein kinase TAO2
Authors:Zhou, T, Sun, L, Gao, Y, Earnest, S, Cobb, M.H, Goldsmith, E.J.
Deposit date:2006-03-14
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.
Acta Biochim.Biophys.Sinica, 38, 2006
2GPH
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BU of 2gph by Molmil
Docking motif interactions in the MAP kinase ERK2
Descriptor: Mitogen-activated protein kinase 1, Tyrosine-protein phosphatase non-receptor type 7
Authors:Zhou, T, Sun, L, Humphreys, J, Goldsmith, E.J.
Deposit date:2006-04-17
Release date:2006-07-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2.
Structure, 14, 2006
2LRU
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BU of 2lru by Molmil
Solution Structure of the WNK1 Autoinhibitory Domain
Descriptor: Serine/threonine-protein kinase WNK1
Authors:Moon, T.M, Correa, F, Gardner, K.H, Goldsmith, E.J.
Deposit date:2012-04-13
Release date:2012-05-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain.
J.Mol.Biol., 425, 2013
3N29
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BU of 3n29 by Molmil
Crystal structure of carboxynorspermidine decarboxylase complexed with Norspermidine from Campylobacter jejuni
Descriptor: Carboxynorspermidine decarboxylase, GLYCEROL, N-(3-aminopropyl)propane-1,3-diamine, ...
Authors:Deng, X, Lee, J, Michael, A.J, Tomchick, D.R, Goldsmith, E.J, Phillips, M.A.
Deposit date:2010-05-17
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010
3N2O
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BU of 3n2o by Molmil
X-ray crystal structure of arginine decarboxylase complexed with Arginine from Vibrio vulnificus
Descriptor: AGMATINE, Biosynthetic arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Deng, X, Lee, J, Michael, A.J, Tomchick, D.R, Goldsmith, E.J, Phillips, M.A.
Deposit date:2010-05-18
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010

 

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