Author results

6M8W
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PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR AIAF
Descriptor:SEDOLISIN, AIAF PEPTIDE INHIBITOR, CALCIUM ION, ...
Authors:Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Goldfarb, N.E., Dunn, B.M., Oda, K.
Deposit date:2018-08-22
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry, 40, 2001
6M8Y
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PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR AIPF
Descriptor:SEDOLISIN, AIPF PEPTIDE INHIBITOR, CALCIUM ION, ...
Authors:Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Goldfarb, N.E., Dunn, B.M., Oda, K.
Deposit date:2018-08-22
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry, 40, 2001
6M9C
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PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR PSEUDOTYROSTATIN
Descriptor:SEDOLISIN, Pseudotyrostatin, CALCIUM ION, ...
Authors:Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Goldfarb, N.E., Dunn, B.M., Oda, K.
Deposit date:2018-08-23
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry, 40, 2001
6M9D
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PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR CHYMOSTATIN
Descriptor:SEDOLISIN, Chymostatin A, CALCIUM ION
Authors:Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Goldfarb, N.E., Dunn, B.M., Oda, K.
Deposit date:2018-08-23
Release date:2018-10-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry, 40, 2001
6M9F
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PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR TYROSTATIN
Descriptor:SEDOLISIN, Tyrostatin, CALCIUM ION, ...
Authors:Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Goldfarb, N.E., Dunn, B.M., Oda, K.
Deposit date:2018-08-23
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry, 40, 2001
4QGI
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X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE VARIANT G48T/L89M IN COMPLEX WITH SAQUINAVIR
Descriptor:Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, GLYCEROL
Authors:Mahon, B.P., McKenna, R., Goldfarb, N.
Deposit date:2014-05-22
Release date:2014-07-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency.
Biochemistry, 54, 2015
5UGQ
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CRYSTAL STRUCTURE OF HIP1 (RV2224C)
Descriptor:Carboxylesterase A
Authors:Naffin-Olivos, J.L., Daab, A., White, A., Goldfarb, N., Milne, A.C., Liu, D., Dunn, B.M., Rengarajan, J., Petsko, G.A., Ringe, D.
Deposit date:2017-01-09
Release date:2017-04-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
5UNO
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CRYSTAL STRUCTURE OF HIP1 (RV2224C)
Descriptor:Carboxylesterase A
Authors:Naffin-Olivos, J.L., Daab, A., White, A., Goldfarb, N., Milne, A.C., Liu, D., Dunn, B.M., Rengarajan, J., Petsko, G.A., Ringe, D.
Deposit date:2017-01-31
Release date:2017-04-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
5UOH
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CRYSTAL STRUCTURE OF HIP1 (RV2224C) T466A MUTANT
Descriptor:Carboxylesterase A
Authors:Naffin-Olivos, J.L., Daab, A., White, A., Goldfarb, N., Milne, A.C., Liu, D., Baikovitz, J., Dunn, B.M., Rengarajan, J., Petsko, G.A., Ringe, D.
Deposit date:2017-01-31
Release date:2017-04-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
3SLZ
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THE CRYSTAL STRUCTURE OF XMRV PROTEASE COMPLEXED WITH TL-3
Descriptor:gag-pro-pol polyprotein, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, FORMIC ACID, ...
Authors:Li, M., Gustchina, A., Wlodawer, A.
Deposit date:2011-06-27
Release date:2011-10-12
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.
Febs J., 278, 2011
3SM1
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THE CRYSTAL STRUCTURE OF XMRV PROTEASE COMPLEXED WITH PEPSTATIN A
Descriptor:gag-pro-pol polyprotein, Pepstatin A, FORMIC ACID
Authors:Li, M., Gustchina, A., Wlodawer, A.
Deposit date:2011-06-27
Release date:2011-10-12
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.
Febs J., 278, 2011
3SM2
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THE CRYSTAL STRUCTURE OF XMRV PROTEASE COMPLEXED WITH AMPRENAVIR
Descriptor:gag-pro-pol polyprotein, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER
Authors:Li, M., Gustchina, A., Wlodawer, A.
Deposit date:2011-06-27
Release date:2011-10-12
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.
Febs J., 278, 2011
5KQX
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PROTEASE E35D-SQV
Descriptor:Protease E35D-SQV, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
Authors:Liu, Z., Poole, K.M., Mahon, B.P., McKenna, R., Fanucci, G.E.
Deposit date:2016-07-06
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
J.Biol.Chem., 291, 2016
5KQY
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PROTEASE E35D-DRV
Descriptor:Protease E35D-DRV, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
Authors:Liu, Z., Poole, K.M., Mahon, B.P., McKenna, R., Fanucci, G.E.
Deposit date:2016-07-06
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
J.Biol.Chem., 291, 2016
5KQZ
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PROTEASE E35D-CAP2
Descriptor:Protease, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Liu, Z., Poole, K.M., Mahon, B.P., McKenna, R., Fanucci, G.E.
Deposit date:2016-07-06
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
J.Biol.Chem., 291, 2016
5KR0
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PROTEASE E35D-APV
Descriptor:Protease E35D-APV, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, GLYCEROL
Authors:Liu, Z., Poole, K.M., Mahon, B.P., McKenna, R., Fanucci, G.E.
Deposit date:2016-07-06
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
J.Biol.Chem., 291, 2016
5KR1
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PROTEASE PR5-DRV
Descriptor:Protease PR5-DRV, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
Authors:Liu, Z., Poole, K.M., Mahon, B.P., McKenna, R., Fanucci, G.E.
Deposit date:2016-07-06
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
J.Biol.Chem., 291, 2016
5KR2
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PROTEASE PR5-SQV
Descriptor:Protease PR5-SQV, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
Authors:Liu, Z., Poole, K.M., Mahon, B.P., McKenna, R., Fanucci, G.E.
Deposit date:2016-07-06
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
J.Biol.Chem., 291, 2016