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1PY4
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BETA2 MICROGLOBULIN MUTANT H31Y DISPLAYS HINTS FOR AMYLOID FORMATIONS
Descriptor:Beta-2-microglobulin precursor
Authors:Rosano, C., Zuccotti, S., Mangione, P., Giorgetti, S., Bellotti, V., Pettirossi, F., Corazza, A., Viglino, P., Esposito, G., Bolognesi, M.
Deposit date:2003-07-08
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation
J.Mol.Biol., 335, 2004
2VB5
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SOLUTION STRUCTURE OF W60G MUTANT OF HUMAN BETA2-MICROGLOBULIN
Descriptor:BETA-2-MICROGLOBULIN
Authors:Esposito, G., Corazza, A., Rennella, E., Gumral, D., Mimmi, M.C., Fogolari, F., Viglino, P., Raimondi, S., Giorgetti, S., Bolognesi, B., Merlini, G., Stoppini, M., Bellotti, V.
Deposit date:2007-09-06
Release date:2007-09-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Controlling Roles of Trp60 and Trp95 in Beta2-Microglobulin Function, Folding and Amyloid Aggregation Properties.
J.Mol.Biol., 378, 2008
2Z9T
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CRYSTAL STRUCTURE OF THE HUMAN BETA-2 MICROGLOBULIN MUTANT W60G
Descriptor:Beta-2-microglobulin
Authors:Ricagno, S., Bolognesi, M., Bellotti, V., Corazza, A., Rennella, E., Gural, D., Mimmi, M.C., Betto, E., Pucillo, C., Fogolari, F., Viglino, P., Raimondi, S., Giorgetti, S., Bolognesi, B., Merlini, G., Stoppini, M.
Deposit date:2007-09-26
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties
J.Mol.Biol., 378, 2008
3DHJ
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BETA 2 MICROGLOBULIN MUTANT W60C
Descriptor:Beta-2-microglobulin
Authors:Ricagno, S., Colombo, M., de Rosa, M., Bolognesi, M., Giorgetti, S., Bellotti, V.
Deposit date:2008-06-18
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:DE loop mutations affect beta2-microglobulin stability and amyloid aggregation
Biochem.Biophys.Res.Commun., 377, 2008
3DHM
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BETA 2 MICROGLOBULIN MUTANT D59P
Descriptor:Beta-2-microglobulin
Authors:Ricagno, S., Colombo, M., de Rosa, M., Bolognesi, M., Giorgetti, S., Bellotti, V.
Deposit date:2008-06-18
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DE loop mutations affect beta2-microglobulin stability and amyloid aggregation
Biochem.Biophys.Res.Commun., 377, 2008
4L29
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STRUCTURE OF WTMHC CLASS I WITH NY-ESO1 DOUBLE MUTANT
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Halabelian, L., Giorgetti, S., Bellotti, V., Bolognesi, M., Ricagno, S.
Deposit date:2013-06-04
Release date:2013-12-25
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
4L3C
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STRUCTURE OF HLA-A2 IN COMPLEX WITH D76N B2M MUTANT AND NY-ESO1 DOUBLE MUTANT
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Halabelian, L., Giorgetti, S., Bellotti, V., Bolognesi, M., Ricagno, S.
Deposit date:2013-06-05
Release date:2013-12-25
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
1JNJ
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NMR SOLUTION STRUCTURE OF THE HUMAN BETA2-MICROGLOBULIN
Descriptor:beta2-microglobulin
Authors:Verdone, G., Corazza, A., Viglino, P., Pettirossi, F., Giorgetti, S., Mangione, P., Andreola, A., Stoppini, M., Bellotti, V., Esposito, G.
Deposit date:2001-07-24
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition.
Protein Sci., 11, 2002
3EKC
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STRUCTURE OF W60V BETA-2 MICROGLOBULIN MUTANT
Descriptor:Beta-2-microglobulin
Authors:Ricagno, S., Sangiovanni, E., Bellotti, V., Bolognesi, M.
Deposit date:2008-09-19
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation
Biochem.Biophys.Res.Commun., 380, 2009
3NA4
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D53P BETA-2 MICROGLOBULIN MUTANT
Descriptor:Beta-2-microglobulin, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
Authors:Azinas, S., Ricagno, S., Bolognesi, M.
Deposit date:2010-06-01
Release date:2011-06-01
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:D-strand perturbation and amyloid propensity in beta-2 microglobulin
Febs J., 278, 2011
4FXL
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CRYSTAL STRUCTURE OF THE D76N BETA-2 MICROGLOBULIN MUTANT
Descriptor:Beta-2-microglobulin, SODIUM ION, ACETATE ION, ...
Authors:Ricagno, S., Bellotti, V., Pepys, M.B., Stoppini, M., Bolognesi, M.
Deposit date:2012-07-03
Release date:2012-08-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Hereditary systemic amyloidosis due to Asp76Asn variant beta-2-microglobulin.
N.Engl.J.Med., 366, 2012
2X89
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STRUCTURE OF THE BETA2_MICROGLOBULIN INVOLVED IN AMYLOIDOGENESIS
Descriptor:ANTIBODY, BETA-2-MICROGLOBULIN
Authors:Domanska, K., Srinivasan, V., Vanderhaegen, S., Pardon, E., Marquez, J.A., Bellotti, V., Wyns, L., Steyaert, J.
Deposit date:2010-03-07
Release date:2011-01-19
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Atomic Structure of a Nanobody-Trapped Domain-Swapped Dimer of an Amyloidogenic {Beta}2-Microglobulin Variant.
Proc.Natl.Acad.Sci.USA, 108, 2011
4RMQ
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CRYSTAL STRUCTURE OF THE D59N BETA-2 MICROGLOBULIN MUTANT
Descriptor:Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER
Authors:de Rosa, M., Bolognesi, M., Ricagno, S.
Deposit date:2014-10-22
Release date:2015-11-18
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.461 Å)
Cite:Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.
Plos One, 10, 2015
4RMR
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CRYSTAL STRUCTURE OF THE D38N BETA-2 MICROGLOBULIN MUTANT
Descriptor:Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ACETATE ION
Authors:de Rosa, M., Bolognesi, M., Ricagno, S.
Deposit date:2014-10-22
Release date:2015-11-18
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.529 Å)
Cite:Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.
Plos One, 10, 2015
4RMS
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CRYSTAL STRUCTURE OF THE D53N BETA-2 MICROGLOBULIN MUTANT
Descriptor:Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ACETATE ION
Authors:de Rosa, M., Bolognesi, M., Ricagno, S.
Deposit date:2014-10-22
Release date:2015-11-18
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.
Plos One, 10, 2015
4RMT
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CRYSTAL STRUCTURE OF THE D98N BETA-2 MICROGLOBULIN MUTANT
Descriptor:Beta-2-microglobulin, TRIETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ...
Authors:de Rosa, M., Bolognesi, M., Ricagno, S.
Deposit date:2014-10-22
Release date:2015-11-18
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.242 Å)
Cite:Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.
Plos One, 10, 2015
4MRB
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WILD TYPE HUMAN TRANSTHYRETIN PH 7.5
Descriptor:Transthyretin, CALCIUM ION
Authors:Chen, W.J., Wood, S.P.
Deposit date:2013-09-17
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.
Proc.Natl.Acad.Sci.USA, 111, 2014
4MRC
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HUMAN TRANSTHYRETIN SER52PRO MUTANT
Descriptor:Transthyretin, CALCIUM ION
Authors:Chen, W.J., Wood, S.P.
Deposit date:2013-09-17
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.
Proc.Natl.Acad.Sci.USA, 111, 2014