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1N3K
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SOLUTION STRUCTURE OF PHOSPHOPROTEIN ENRICHED IN ASTROCYTES 15 KDA (PEA-15)
Descriptor:Astrocytic phosphoprotein PEA-15
Authors:Hill, J.M., Vaidyanathan, H., Ramos, J.W., Ginsberg, M.H., Werner, M.H.
Deposit date:2002-10-28
Release date:2003-01-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain
Embo J., 21, 2002
1MIX
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CRYSTAL STRUCTURE OF A FERM DOMAIN OF TALIN
Descriptor:Talin
Authors:Garcia-Alvarez, B., de Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-23
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
1MIZ
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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor:integrin beta3, TALIN
Authors:Garcia-Alvarez, B., de Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-23
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
1MK7
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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor:Integrin Beta3, TALIN
Authors:Garcia-Alvarez, B., De Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-28
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
1MK9
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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor:Integrin Beta3, TALIN
Authors:Garcia-Alvarez, B., De Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-28
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
1Y19
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STRUCTURAL BASIS FOR PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE I-GAMMA BINDING TO TALIN AT FOCAL ADHESIONS
Descriptor:Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, Talin 1
Authors:de Pereda, J.M., Wegener, K., Santelli, E., Bate, N., Ginsberg, M.H., Critchley, D.R., Campbell, I.D., Liddington, R.C.
Deposit date:2004-11-17
Release date:2005-01-04
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural bases for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
J.Biol.Chem., 280, 2005
2K9J
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INTEGRIN ALPHAIIB-BETA3 TRANSMEMBRANE COMPLEX
Descriptor:Integrin alpha-IIb light chain, Integrin beta-3
Authors:Lau, T., Kim, C., Ginsberg, M.H., Ulmer, T.S.
Deposit date:2008-10-15
Release date:2009-03-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling
Embo J., 28, 2009
2NA8
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TRANSMEMBRANE STRUCTURE OF THE CYTOKINE RECEPTOR COMMON SUBUNIT BETA
Descriptor:Cytokine receptor common subunit beta
Authors:Schmidt, T., Ye, F., Situ, A.J., An, W., Ginsberg, M.H., Ulmer, T.S.
Deposit date:2015-12-21
Release date:2016-07-06
Last modified:2016-09-07
Method:SOLUTION NMR
Cite:A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.
J.Biol.Chem., 291, 2016
2NA9
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TRANSMEMBRANE STRUCTURE OF THE P441A MUTANT OF THE CYTOKINE RECEPTOR COMMON SUBUNIT BETA
Descriptor:Cytokine receptor common subunit beta
Authors:Schmidt, T., Ye, F., Situ, A.J., An, W., Ginsberg, M.H., Ulmer, T.S.
Deposit date:2015-12-21
Release date:2016-07-06
Last modified:2016-09-07
Method:SOLUTION NMR
Cite:A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.
J.Biol.Chem., 291, 2016
2RMZ
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BICELLE-EMBEDDED INTEGRIN BETA3 TRANSMEMBRANE SEGMENT
Descriptor:Integrin beta-3
Authors:Lau, T.L., Partridge, A.W., Ginsberg, M.H., Ulmer, T.S.
Deposit date:2007-12-04
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Integrin beta3 Transmembrane Segment in Phospholipid Bicelles and Detergent Micelles
Biochemistry, 47, 2008
2RN0
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MICELLE-EMBEDDED INTEGRIN BETA3 TRANSMEMBRANE SEGMENT
Descriptor:Integrin beta-3
Authors:Lau, T.L., Partridge, A.W., Ginsberg, M.H., Ulmer, T.S.
Deposit date:2007-12-04
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Integrin beta3 Transmembrane Segment in Phospholipid Bicelles and Detergent Micelles
Biochemistry, 47, 2008
3G9W
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CRYSTAL STRUCTURE OF TALIN2 F2-F3 IN COMPLEX WITH THE INTEGRIN BETA1D CYTOPLASMIC TAIL
Descriptor:Talin-2, Integrin beta-1D, GLYCEROL, ...
Authors:Anthis, N.J., Wegener, K.L., Ye, F., Kim, C., Lowe, E.D., Vakonakis, I., Bate, N., Critchley, D.R., Ginsberg, M.H., Campbell, I.D.
Deposit date:2009-02-15
Release date:2009-10-20
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.165 Å)
Cite:The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
3U7D
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CRYSTAL STRUCTURE OF THE KRIT1/CCM1 FERM DOMAIN IN COMPLEX WITH THE HEART OF GLASS (HEG1) CYTOPLASMIC TAIL
Descriptor:Krev interaction trapped protein 1, Protein HEG homolog 1
Authors:Gingras, A.R., Liu, J.J., Ginsberg, M.H., Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT)
Deposit date:2011-10-13
Release date:2012-09-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.
J.Cell Biol., 199, 2012
4X6Q
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AN ISOFORM-SPECIFIC MYRISTYLATION SWITCH TARGETS RIIB PKA HOLOENZYMES TO MEMBRANES
Descriptor:cAMP-dependent protein kinase type II-beta regulatory subunit, cAMP-dependent protein kinase catalytic subunit alpha
Authors:Zhang, P., Ye, F., Bastidas, A.C., Kornev, A.P., Ginsberg, M.H., Taylor, S.S.
Deposit date:2014-12-08
Release date:2015-07-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
Structure, 23, 2015
4X6R
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AN ISOFORM-SPECIFIC MYRISTYLATION SWITCH TARGETS RIIB PKA HOLOENZYMES TO MEMBRANES
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit, SULFATE ION, ...
Authors:Zhang, P., Ye, F., Bastidas, A.C., Kornev, A.P., Ginsberg, M.H., Wu, J., Taylor, S.S.
Deposit date:2014-12-09
Release date:2015-07-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
Structure, 23, 2015
2H7D
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SOLUTION STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH A CHIMERIC BETA3 INTEGRIN-PIP KINASE PEPTIDE
Descriptor:Talin-1, Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2H7E
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SOLUTION STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH A CHIMERIC BETA3 INTEGRIN-PIP KINASE PEPTIDE- MINIMIZED AVERAGE STRUCTURE
Descriptor:Talin-1, Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2L91
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STRUCTURE OF THE INTEGRIN BETA3 (A711P,K716A) TRANSMEMBRANE SEGMENT
Descriptor:Integrin beta-3
Authors:Schmidt, T., Ulmer, T.S.
Deposit date:2011-01-27
Release date:2011-12-21
Last modified:2012-01-25
Method:SOLUTION NMR
Cite:Basic amino-acid side chains regulate transmembrane integrin signalling.
Nature, 481, 2012
3DYJ
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CRYSTAL STRUCTURE A TALIN ROD FRAGMENT
Descriptor:TALIN-1
Authors:Gingras, A.R., Joyce, M.G., Critchley, D.R., Emsley, J.
Deposit date:2008-07-28
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural determinants of integrin binding to the talin rod
J.Biol.Chem., 284, 2009
4HDO
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CRYSTAL STRUCTURE OF THE BINARY COMPLEX OF KRIT1 BOUND TO THE RAP1 GTPASE
Descriptor:Krev interaction trapped protein 1, Ras-related protein Rap-1b, GLYCEROL, ...
Authors:Gingras, A.R.
Deposit date:2012-10-02
Release date:2013-07-10
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail.
J.Biol.Chem., 288, 2013
4HDQ
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF KRIT1 BOUND TO BOTH THE RAP1 GTPASE AND THE HEART OF GLASS (HEG1) CYTOPLASMIC TAIL
Descriptor:Krev interaction trapped protein 1, Ras-related protein Rap-1b, Protein HEG homolog 1, ...
Authors:Gingras, A.R.
Deposit date:2012-10-02
Release date:2013-07-10
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail.
J.Biol.Chem., 288, 2013
5KHO
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RASIP1 RA DOMAIN IN COMPLEX WITH RAP1B
Descriptor:Ras-interacting protein 1, Ras-related protein Rap-1b, GLYCEROL, ...
Authors:Gingras, A.R.
Deposit date:2016-06-15
Release date:2016-10-19
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins.
Structure, 24, 2016
5KHQ
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RASIP1 RA DOMAIN
Descriptor:Ras-interacting protein 1, GLYCEROL
Authors:Gingras, A.R.
Deposit date:2016-06-15
Release date:2016-10-19
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins.
Structure, 24, 2016