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6G0O
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ACETYLATED ATRX PEPTIDE (K1030AC/K1033AC)
Descriptor:Bromodomain-containing protein 4, Transcriptional regulator ATRX, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Newman, J., Sorrell, F., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0P
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ACETYLATED E2F1 PEPTIDE (K117AC/K120AC)
Descriptor:Bromodomain-containing protein 4, Transcription factor E2F1, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Krojer, T., Sorrell, F., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0Q
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ACETYLATED GATA1 PEPTIDE (K312AC/K315AC)
Descriptor:Bromodomain-containing protein 4, Erythroid transcription factor, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Newman, J., Sorrell, F., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0R
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ACETYLATED POLR2A PEPTIDE (K775AC/K778AC)
Descriptor:Bromodomain-containing protein 4, DNA-directed RNA polymerase II subunit RPB1, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0S
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ACETYLATED SIRT7 PEPTIDE (K272AC/K275AC)
Descriptor:Bromodomain-containing protein 4, NAD-dependent protein deacetylase sirtuin-7, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6FDL
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CRYSTAL STRUCTURE OF THE NYN DOMAIN OF HUMAN MARF1
Descriptor:Meiosis regulator and mRNA stability factor 1
Authors:Jinek, M., Brandmann, T.
Deposit date:2017-12-26
Release date:2018-11-07
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46, 2018
6BXI
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X-RAY CRYSTAL STRUCTURE OF NDR1 KINASE DOMAIN
Descriptor:Serine/threonine-protein kinase 38, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Xiong, S., Sicheri, F.
Deposit date:2017-12-18
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Structure, 26, 2018
6F9S
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CRYSTAL STRUCTURE OF THE C-TERMINAL RECA DOMAIN OF DDX6 IN COMPLEX WITH A CONSERVED PEPTIDE FROM LSM14
Descriptor:Probable ATP-dependent RNA helicase DDX6, Cytokinesis, Apoptosis, ...
Authors:Jinek, M., Brandmann, T.
Deposit date:2017-12-15
Release date:2018-03-21
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6F9W
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CRYSTAL STRUCTURE OF THE LSM DOMAIN OF LSM14 IN COMPLEX WITH A C-TERMINAL PEPTIDE OF 4E-T
Descriptor:Protein LSM14 homolog A, Eukaryotic translation initiation factor 4E transporter
Authors:Brandmann, T., Jinek, M.
Deposit date:2017-12-15
Release date:2018-03-21
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.623 Å)
Cite:Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6AMB
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CRYSTAL STRUCTURE OF THE AFADIN RA1 DOMAIN IN COMPLEX WITH HRAS
Descriptor:GTPase HRas, Afadin, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Smith, M.J., Ishiyama, N., Ikura, M.
Deposit date:2017-08-09
Release date:2017-11-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
Nat Commun, 8, 2017
5WI4
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CRYSTAL STRUCTURE OF DYNLT1/TCTEX-1 IN COMPLEX WITH ARHGEF2
Descriptor:Dynein light chain Tctex-type 1,Rho guanine nucleotide exchange factor 2, SULFATE ION
Authors:Balan, M., Ishiyama, N., Marshall, C.B., Ikura, M.
Deposit date:2017-07-18
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
Sci Signal, 10, 2017
5NNC
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIACETYLATED HISTONE 4 PEPTIDE (H3K9AC/K14AC)
Descriptor:Bromodomain-containing protein 4, Histone H3
Authors:Filippakopoulos, P., Picaud, S., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NND
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIACETYLATED HISTONE 4 PEPTIDE (H3K9AC/K14AC)
Descriptor:Bromodomain-containing protein 4, Histone H3, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NNE
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIACETYLATED TOP2A PEPTIDE (K1201AC/K1204AC)
Descriptor:Bromodomain-containing protein 4, GKA(ALY)GK(ALY)TQMY, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NNF
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ACETYLATED BAZ1B PEPTIDE (K221AC)
Descriptor:Bromodomain-containing protein 4, FLPH(ALY)YDVKL
Authors:Filippakopoulos, P., Picaud, S., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NNG
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ACETYLATED SRPK1 PEPTIDE (K585AC)
Descriptor:Bromodomain-containing protein 4, VAG(ALY)YS(ALY)EFFY, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Newman, J., Sorrell, F., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Structural Genomics Consortium (SGC)
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5TWF
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REGULATION OF PROTEIN INTERACTIONS BY MOB1 PHOSPHORYLATION
Descriptor:MOB kinase activator 1A, ZINC ION
Authors:Xiong, S., Sicheri, F.
Deposit date:2016-11-13
Release date:2017-04-12
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3.136 Å)
Cite:Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.
Mol. Cell Proteomics, 16, 2017
5TWG
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HUMAN MOB1A BOUND TO HUMAN MST1 PHOSPHORYLATED T353 PEPTIDE
Descriptor:MOB kinase activator 1A, T353 peptide, ZINC ION
Authors:Xiong, S., Sicheri, F.
Deposit date:2016-11-13
Release date:2017-04-12
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
Mol. Cell Proteomics, 16, 2017
5TWH
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HUMAN MOB1A BOUND TO MST1 PHOSPHORYLATED T367 PEPTIDE
Descriptor:MOB kinase activator 1A, T367 peptide, ZINC ION
Authors:Xiong, S., Sicheri, F.
Deposit date:2016-11-13
Release date:2017-04-12
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
Mol. Cell Proteomics, 16, 2017
5IGK
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH BROMOSPORINE (BSP)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, Bromosporine
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-02-28
Release date:2016-10-19
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Sci Adv, 2, 2016
5IGL
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF HUMAN TAF1L IN COMPLEX WITH BROMOSPORINE (BSP)
Descriptor:Transcription initiation factor TFIID subunit 1-like, Bromosporine
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Krojer, T., Tallant, C., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-02-28
Release date:2016-10-19
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Sci Adv, 2, 2016
5IGM
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRD9 IN COMPLEX WITH BROMOSPORINE (BSP)
Descriptor:Bromodomain-containing protein 9, Bromosporine
Authors:Tallant, C., Filippakopoulos, P., Picaud, S., Nunez-Alonso, G., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-02-28
Release date:2016-10-19
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Sci Adv, 2, 2016
4ZX2
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CO-CRYSTAL STRUCTURES OF PP5 IN COMPLEX WITH 5-METHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC ACID
Descriptor:Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ...
Authors:Chattopadhyay, D., Swingle, M.R., Salter, E.A., Wierzbicki, A., Honkanen, R.E.
Deposit date:2015-05-19
Release date:2016-04-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
4ZVZ
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CO-CRYSTAL STRUCTURES OF PP5 IN COMPLEX WITH 5-METHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC ACID
Descriptor:Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1R,2S,3R,4S,5S)-5-(propoxymethyl)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ...
Authors:Chattopadhyay, D., Swingle, M.R., Salter, E.A., Wierzbicki, A., Honkanen, R.E.
Deposit date:2015-05-18
Release date:2016-04-27
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
4COS
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CRYSTAL STRUCTURE OF THE PHD-BROMO-PWWP CASSETTE OF HUMAN PRKCBP1
Descriptor:PROTEIN KINASE C-BINDING PROTEIN 1, ZINC ION, 1,4-DIETHYLENE DIOXIDE
Authors:Krojer, T., Savitsky, P., Newman, J.A., Cooper, C.D.O., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Filippakopoulos, P.
Deposit date:2014-01-30
Release date:2014-03-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Cell Rep, 17, 2016
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