Author results

4HNA
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KINESIN MOTOR DOMAIN IN THE ADP-MG-ALFX STATE IN COMPLEX WITH TUBULIN AND A DARPIN
Descriptor:Tubulin alpha chain, Tubulin beta chain, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D2, ...
Authors:Gigant, B., Knossow, M.
Deposit date:2012-10-19
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of a kinesin-tubulin complex and implications for kinesin motility.
Nat.Struct.Mol.Biol., 20, 2013
1CT8
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CATALYTIC ANTIBODY 7C8 COMPLEX
Descriptor:7C8 FAB FRAGMENT; SHORT CHAIN, 7C8 FAB FRAGMENT; LONG CHAIN, SULFATE ION, ...
Authors:Gigant, B., Tsumuraya, T., Fujii, I., Knossow, M.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Diverse structural solutions to catalysis in a family of antibodies.
Structure Fold.Des., 7, 1999
1FFX
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TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:PROTEIN (TUBULIN), PROTEIN (STATHMIN-LIKE DOMAIN OF RB3), GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gigant, B., Martin-Barbey, C., Knossow, M.
Deposit date:2000-07-26
Release date:2000-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:The 4 A X-ray structure of a tubulin:stathmin-like domain complex.
Cell(Cambridge,Mass.), 102, 2000
1YEF
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STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH SUBSTRATE ANALOGUE
Descriptor:IGG2A FAB FRAGMENT, ZINC ION, PARA-NITROBENZYL GLUTARYL GLYCINIC ACID
Authors:Gigant, B., Knossow, M.
Deposit date:1997-05-29
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Proc.Natl.Acad.Sci.USA, 94, 1997
1YEG
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STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT
Descriptor:IGG2A FAB FRAGMENT, ZINC ION, PARANITROBENZYL ALCOHOL, ...
Authors:Gigant, B., Knossow, M.
Deposit date:1997-05-29
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Proc.Natl.Acad.Sci.USA, 94, 1997
1YEH
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STRUCTURE OF IGG2A FAB FRAGMENT
Descriptor:FAB FRAGMENT, ZINC ION
Authors:Gigant, B., Knossow, M.
Deposit date:1997-05-29
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Proc.Natl.Acad.Sci.USA, 94, 1997
1YEI
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CATALYTIC ANTIBODY D2.3 COMPLEX
Descriptor:PROTEIN (IG ANTIBODY D2.3 (LIGHT CHAIN)), PROTEIN (IG ANTIBODY D2.3 (HEAVY CHAIN)), ZINC ION, ...
Authors:Gigant, B., Knossow, M.
Deposit date:1998-08-13
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crossreactivity, efficiency and catalytic specificity of an esterase-like antibody.
J.Mol.Biol., 284, 1998
1YEJ
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CATALYTIC ANTIBODY COMPLEX
Descriptor:PROTEIN (IG ANTIBODY D2.3 (LIGHT CHAIN)), PROTEIN (IG ANTIBODY D2.3 (HEAVY CHAIN)), ZINC ION, ...
Authors:Gigant, B., Knossow, M.
Deposit date:1998-08-13
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crossreactivity, efficiency and catalytic specificity of an esterase-like antibody.
J.Mol.Biol., 284, 1998
1YEK
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CATALYTIC ANTIBODY D2.3 COMPLEX
Descriptor:PROTEIN (IG ANTIBODY D2.3 (LIGHT CHAIN)), PROTEIN (IG ANTIBODY D2.3 (HEAVY CHAIN)), ZINC ION, ...
Authors:Gigant, B., Knossow, M.
Deposit date:1998-08-13
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crossreactivity, efficiency and catalytic specificity of an esterase-like antibody.
J.Mol.Biol., 284, 1998
1Z2B
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TUBULIN-COLCHICINE-VINBLASTINE: STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, RB3 STATHMIN-LIKE DOMAIN 4, ...
Authors:Gigant, B., Wang, C., Ravelli, R.B.G., Roussi, F., Steinmetz, M.O., Curmi, P.A., Sobel, A., Knossow, M.
Deposit date:2005-03-08
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structural basis for the regulation of tubulin by vinblastine.
Nature, 435, 2005
4F61
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TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, Stathmin-like domain R4, ...
Authors:Gigant, B., Mignot, I., Knossow, M.
Deposit date:2012-05-14
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (4.17 Å)
Cite:Design and characterization of modular scaffolds for tubulin assembly.
J.Biol.Chem., 287, 2012
4F6R
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TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, Stathmin-like domain R1, ...
Authors:Gigant, B., Mignot, I., Knossow, M.
Deposit date:2012-05-15
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Design and characterization of modular scaffolds for tubulin assembly.
J.Biol.Chem., 287, 2012
1KN2
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CATALYTIC ANTIBODY D2.3 COMPLEX
Descriptor:IG ANTIBODY D2.3 (LIGHT CHAIN), IG ANTIBODY D2.3 (HEAVY CHAIN), ZINC ION, ...
Authors:Gigant, B., Knossow, M.
Deposit date:2001-12-18
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody.
J.Am.Chem.Soc., 124, 2002
1KN4
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CATALYTIC ANTIBODY D2.3 COMPLEX
Descriptor:IG ANTIBODY D2.3 (LIGHT CHAIN), IG ANTIBODY D2.3 (HEAVY CHAIN), ZINC ION, ...
Authors:Gigant, B., Knossow, M.
Deposit date:2001-12-18
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody.
J.Am.Chem.Soc., 124, 2002
6GWC
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TUBULIN:IE5 ALPHAREP COMPLEX
Descriptor:ALPHA-TUBULIN, Tubulin beta chain, iE5 ALPHAREP, ...
Authors:Gigant, B., Campanacci, V.
Deposit date:2018-06-22
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selection and Characterization of Artificial Proteins Targeting the Tubulin alpha Subunit.
Structure, 27, 2019
6GWD
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TUBULIN:IIH5 ALPHAREP COMPLEX
Descriptor:ALPHA-TUBULIN, Tubulin beta chain, iiH5 ALPHAREP, ...
Authors:Gigant, B., Campanacci, V.
Deposit date:2018-06-22
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Selection and Characterization of Artificial Proteins Targeting the Tubulin alpha Subunit.
Structure, 27, 2019
1KNO
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CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES
Descriptor:IGG2A FAB FRAGMENT CNJ206, ZINC ION, METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
Authors:Charbonnier, J.-B., Gigant, B., Knossow, M.
Deposit date:1995-09-11
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the complex of a catalytic antibody Fab fragment with a transition state analog: structural similarities in esterase-like catalytic antibodies.
Proc.Natl.Acad.Sci.USA, 92, 1995
1KEN
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INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION
Descriptor:hemagglutinin HA1, hemagglutinin HA2, influenza virus infectivity neutralizing antibody (light chain), ...
Authors:Barbey-Martin, C., Gigant, B., Bizebard, T., Calder, L.J., Wharto, S.A., Skehel, J.J., Knossow, M.
Deposit date:2001-11-16
Release date:2002-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:An Antibody that Prevents the Hemagglutinin Low pH Fusogenic Transition
VIROLOGY, 294, 2002
1QFU
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INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY
Descriptor:PROTEIN (HEMAGGLUTININ (HA1 CHAIN)), PROTEIN (HEMAGGLUTININ (HA2 CHAIN)), PROTEIN (IMMUNOGLOBULIN IGG1-KAPPA ANTIBODY (LIGHT CHAIN)), ...
Authors:Fleury, D., Gigant, B., Bizebard, T., Daniels, R.S., Skehel, J.J., Knossow, M.
Deposit date:1999-04-14
Release date:1999-04-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site.
Nat.Struct.Biol., 6, 1999
4DUI
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DARPIN D1 BINDING TO TUBULIN BETA CHAIN (NOT IN COMPLEX)
Descriptor:DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1, (4S)-2-METHYL-2,4-PENTANEDIOL, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Pecqueur, L., Duellberg, C., Dreier, B., Wang, Q., Jiang, C., Pluckthun, A., Surrey, T., Gigant, B., Knossow, M.
Deposit date:2012-02-22
Release date:2013-02-27
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:An Anti-Tubulin Darpin Caps the Microtubule Plus-End
To be Published
4DRX
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GTP-TUBULIN IN COMPLEX WITH A DARPIN
Descriptor:Tubulin alpha chain, Tubulin beta chain, Designed ankyrin repeat protein (DARPIN) D1, ...
Authors:Pecqueur, L., Gigant, B., Knossow, M.
Deposit date:2012-02-17
Release date:2012-07-11
Last modified:2012-08-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end.
Proc.Natl.Acad.Sci.USA, 109, 2012
5EYL
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TUBULIN-BINDING DARPIN
Descriptor:DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), PHOSPHATE ION, GLYCEROL
Authors:Ahmad, S., Kossow, M., Gigant, B.
Deposit date:2015-11-25
Release date:2016-07-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
5EYP
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TUBULIN-DARPIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), ...
Authors:Ahmad, S., Knossow, M., Gigant, B.
Deposit date:2015-11-25
Release date:2016-07-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
1SA0
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TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, Stathmin 4, ...
Authors:Ravelli, R.B., Gigant, B., Curmi, P.A., Jourdain, I., Lachkar, S., Sobel, A., Knossow, M.
Deposit date:2004-02-06
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
Nature, 428, 2004
1SA1
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TUBULIN-PODOPHYLLOTOXIN: STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, Stathmin 4, ...
Authors:Ravelli, R.B., Gigant, B., Curmi, P.A., Jourdain, I., Lachkar, S., Sobel, A., Knossow, M.
Deposit date:2004-02-06
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
Nature, 428, 2004
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