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5F6Z
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SANDERCYANIN FLUORESCENT PROTEIN PURIFIED FROM SANDER VITREUS
Descriptor:Sandercyanin Fluorescent Protein, BILIVERDINE IX ALPHA, N-ACETYL-D-GLUCOSAMINE
Authors:Ghosh, S., Yu, C.L., Ferraro, D., Sudha, S., Pal, S., Schaefer, W., Gibson, D.T., Subramanian, R.
Deposit date:2015-12-07
Release date:2016-09-28
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.248 Å)
Cite:Blue protein with red fluorescence
Proc.Natl.Acad.Sci.USA, 113, 2016
5EZ2
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SANDERCYANIN FLUORESCENT PROTEIN (SFP)
Descriptor:Sandercyanin Fluorescent Protein, BILIVERDINE IX ALPHA, 1,2-ETHANEDIOL
Authors:Ghosh, S., Ramaswamy, S.
Deposit date:2015-11-26
Release date:2016-09-28
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Blue protein with red fluorescence
Proc.Natl.Acad.Sci.USA, 113, 2016
5F1E
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APO PROTEIN OF SANDERCYANIN
Descriptor:Sandercyanin Fluorescent Protein
Authors:Ghosh, S., Ramaswamy, S.
Deposit date:2015-11-30
Release date:2016-09-28
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Blue protein with red fluorescence
Proc.Natl.Acad.Sci.USA, 113, 2016
4LYD
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CRYSTAL STRUCTURE OF THE S105A MUTANT OF A C-C HYDROLASE, DXNB2 FROM SPHINGOMONAS WITTICHII RW1
Descriptor:MCP Hydrolase
Authors:Ghosh, S., Bolin, J.T., Bhowmik, S.
Deposit date:2013-07-31
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The Lid Domain of the MCP Hydrolase DxnB2 Contributes to the Reactivity toward Recalcitrant PCB Metabolites.
Biochemistry, 52, 2013
4LYE
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CRYSTAL STRUCTURE OF THE S105A MUTANT OF A C-C HYDROLASE, DXNB2 FROM SPHINGOMONAS WITTICHII RW1, IN COMPLEX WITH SUBSTRATE HOPDA
Descriptor:MCP Hydrolase, (3E)-2,6-DIOXO-6-PHENYLHEX-3-ENOATE
Authors:Ghosh, S., Bolin, J.T.
Deposit date:2013-07-31
Release date:2013-10-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A substrate-assisted mechanism of nucleophile activation in a ser-his-asp containing C-C bond hydrolase.
Biochemistry, 52, 2013
3V1K
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CRYSTAL STRUCTURE OF THE H265Q MUTANT OF A C-C HYDROLASE, BPHD FROM BURKHOLDERIA XENOVORANS LB400.
Descriptor:2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, MALONIC ACID
Authors:Ghosh, S., Bolin, J.T.
Deposit date:2011-12-09
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Identification of an Acyl-Enzyme Intermediate in a meta-Cleavage Product Hydrolase Reveals the Versatility of the Catalytic Triad.
J.Am.Chem.Soc., 134, 2012
3V1L
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CRYSTAL STRUCTURE OF THE S112A/H265Q MUTANT OF A C-C HYDROLASE, BPHD FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, MALONIC ACID
Authors:Ghosh, S., Bolin, J.T.
Deposit date:2011-12-09
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Identification of an Acyl-Enzyme Intermediate in a meta-Cleavage Product Hydrolase Reveals the Versatility of the Catalytic Triad.
J.Am.Chem.Soc., 134, 2012
3V1M
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CRYSTAL STRUCTURE OF THE S112A/H265Q MUTANT OF A C-C HYDROLASE, BPHD FROM BURKHOLDERIA XENOVORANS LB400, AFTER EXPOSURE TO ITS SUBSTRATE HOPDA
Descriptor:2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, MALONATE ION, (3E)-2,6-DIOXO-6-PHENYLHEX-3-ENOATE
Authors:Ghosh, S., Bolin, J.T.
Deposit date:2011-12-09
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Identification of an Acyl-Enzyme Intermediate in a meta-Cleavage Product Hydrolase Reveals the Versatility of the Catalytic Triad.
J.Am.Chem.Soc., 134, 2012
3V1N
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CRYSTAL STRUCTURE OF THE H265Q MUTANT OF A C-C HYDROLASE, BPHD FROM BURKHOLDERIA XENOVORANS LB400, AFTER EXPOSURE TO ITS SUBSTRATE HOPDA
Descriptor:2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, MALONIC ACID, BENZOIC ACID, ...
Authors:Ghosh, S., Bolin, J.T.
Deposit date:2011-12-09
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Identification of an Acyl-Enzyme Intermediate in a meta-Cleavage Product Hydrolase Reveals the Versatility of the Catalytic Triad.
J.Am.Chem.Soc., 134, 2012
1DF1
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MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE
Descriptor:NITRIC OXIDE SYNTHASE, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Crane, B.R., Rosenfeld, R.J., Arvai, A.S., Ghosh, D.K., Ghosh, S., Tainer, J.A., Stuehr, D.J., Getzoff, E.D.
Deposit date:1999-11-16
Release date:1999-12-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
EMBO J., 18, 1999
1OY3
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CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX
Descriptor:Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Malek, S., Huang, D.B., Huxford, T., Ghosh, S., Ghosh, G.
Deposit date:2003-04-03
Release date:2003-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
1K3Z
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X-RAY CRYSTAL STRUCTURE OF THE IKBB/NF-KB P65 HOMODIMER COMPLEX
Descriptor:Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Shiva, M., Huang, D.B., Chen, Y., Huxford, T., Ghosh, S., Ghosh, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
1NFK
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STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER
Descriptor:DNA (5'-D(*TP*GP*GP*GP*AP*AP*TP*TP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B (NF-KB))
Authors:Ghosh, G., Van Duyne, G., Ghosh, S., Sigler, P.B.
Deposit date:1995-02-28
Release date:1996-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of NF-kappa B p50 homodimer bound to a kappa B site.
Nature, 373, 1995
1RAM
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A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
Descriptor:DNA (5'-D(*CP*GP*GP*CP*TP*GP*GP*AP*AP*AP*TP*TP*TP*CP*CP*AP*GP*CP*CP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR NF-KB P65), 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Chen, Y.-Q., Ghosh, S., Ghosh, G.
Deposit date:1997-11-22
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel DNA recognition mode by the NF-kappa B p65 homodimer.
Nat.Struct.Biol., 5, 1998
2RAM
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A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
Descriptor:DNA (5'-D(*CP*GP*GP*CP*TP*GP*GP*AP*AP*AP*TP*(5IU)P*(5IU)P*CP*CP*AP*GP*CP*CP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR NF-KB P65), (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL
Authors:Chen, Y.Q., Ghosh, S., Ghosh, G.
Deposit date:1997-11-23
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel DNA recognition mode by the NF-kappa B p65 homodimer.
Nat.Struct.Biol., 5, 1998
1EYL
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STRUCTURE OF A RECOMBINANT WINGED BEAN CHYMOTRYPSIN INHIBITOR
Descriptor:CHYMOTRYPSIN INHIBITOR, SULFATE ION
Authors:Dattagupta, J.K., Chakrabarti, C., Ravichandran, S., Ghosh, S.
Deposit date:2000-05-07
Release date:2000-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The role of Asn14 in the stability and conformation of the reactive-site loop of winged bean chymotrypsin inhibitor: crystal structures of two point mutants Asn14-->Lys and Asn14-->Asp.
Protein Eng., 14, 2001
1FMZ
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CRYSTAL STRUCTURE OF A MUTANT WINGED BEAN CHYMOTRYPSIN INHIBITOR PROTEIN, N14K.
Descriptor:CHYMOTRYPSIN INHIBITOR 3, SULFATE ION
Authors:Dattagupta, J.K., Chakrabarti, C., Ravichandran, S., Dasgupta, J., Ghosh, S.
Deposit date:2000-08-19
Release date:2001-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The role of Asn14 in the stability and conformation of the reactive-site loop of winged bean chymotrypsin inhibitor: crystal structures of two point mutants Asn14-->Lys and Asn14-->Asp.
PROTEIN ENG., 14, 2001
1FN0
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STRUCTURE OF A MUTANT WINGED BEAN CHYMOTRYPSIN INHIBITOR PROTEIN, N14D.
Descriptor:CHYMOTRYPSIN INHIBITOR 3, SULFATE ION
Authors:Dattagupta, J.K., Chakrabarti, C., Ravichandran, S., Dasgupta, J., Ghosh, S.
Deposit date:2000-08-19
Release date:2001-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of Asn14 in the stability and conformation of the reactive-site loop of winged bean chymotrypsin inhibitor: crystal structures of two point mutants Asn14-->Lys and Asn14-->Asp.
PROTEIN ENG., 14, 2001
1JWJ
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH W457F MUTATION AT TETRAHYDROBIOPTERIN BINDING SITE
Descriptor:Nitric Oxide Synthase, B-OCTYLGLUCOSIDE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Aoyagi, M., Arvai, A.S., Ghosh, S., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2001-09-04
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry, 40, 2001
1JWK
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH W457A MUTATION AT TETRAHYDROBIOPTERIN BINDING SITE
Descriptor:Nitric Oxide Synthase, Inducible, B-OCTYLGLUCOSIDE, ...
Authors:Aoyagi, M., Arvai, A.S., Ghosh, S., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2001-09-04
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry, 40, 2001
3TTJ
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CRYSTAL STRUCTURE OF JNK3 COMPLEXED WITH CC-359, A JNK INHIBITOR FOR THE PREVENTION OF ISCHEMIA-REPERFUSION INJURY
Descriptor:Mitogen-activated protein kinase 10, 9-cyclopentyl-N~8~-(2-fluorophenyl)-N~2~-(4-methoxyphenyl)-9H-purine-2,8-diamine
Authors:Plantevin-Krenitsky, V., Delgado, M., Nadolny, L., Sahasrabudhe, K., Ayala, S., Clareen, S., Hilgraf, R., Albers, R., Kois, A., Hughes, K., Wright, J., Nowakowski, J., Sudbeck, E., Ghosh, S., Bahmanyar, S., Chamberlain, P., Muir, J., Cathers, B.E., Giegel, D., Xu, L., Celeridad, M., Moghaddam, M., Khatsenko, O., Omholt, P., Katz, J., Pai, S., Fan, R., Tang, Y., Shirley, M.A., Benish, B., Blease, K., Raymon, H., Bhagwat, S., Bennett, B., Satoh, Y.
Deposit date:2011-09-14
Release date:2012-01-25
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.
Bioorg.Med.Chem.Lett., 22, 2012
4DKY
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CRYSTAL STRUCTURE ANALYSIS OF N TERMINAL REGION CONTAINING THE DIMERIZATION DOMAIN AND DNA BINDING DOMAIN OF HU PROTEIN(HISTONE LIKE PROTEIN-DNA BINDING) FROM MYCOBACTERIUM TUBERCULOSIS [H37RV]
Descriptor:DNA-binding protein HU homolog, MANGANESE (II) ION
Authors:Bhowmick, T., Ramagopal, U.A., Ghosh, S., Nagaraja, V., Ramakumar, S.
Deposit date:2012-02-05
Release date:2013-02-06
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.478 Å)
Cite:Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors
Nat Commun, 5, 2014
4PT4
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CRYSTAL STRUCTURE ANALYSIS OF N TERMINAL REGION CONTAINING THE DIMERIZATION DOMAIN AND DNA BINDING DOMAIN OF HU PROTEIN(HISTONE LIKE PROTEIN-DNA BINDING) FROM MYCOBACTERIUM TUBERCULOSIS [H37RV]
Descriptor:DNA-binding protein HU homolog, FORMIC ACID
Authors:Bhowmick, T., Ramagopal, U.A., Ghosh, S., Nagaraja, V., Ramakumar, S.
Deposit date:2014-03-10
Release date:2014-05-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors
Nat Commun, 5, 2014
2M6O
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THE ACTINOBACTERIAL TRANSCRIPTION FACTOR RBPA BINDS TO THE PRINCIPAL SIGMA SUBUNIT OF RNA POLYMERASE
Descriptor:Uncharacterized protein
Authors:Liu, B., Tabib-Salazar, A., Doughty, P., Lewis, R., Ghosh, S., Parsy, M., Simpson, P., Matthews, S., Paget, M.
Deposit date:2013-04-06
Release date:2013-05-08
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase.
Nucleic Acids Res., 41, 2013
3UE8
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KYNURENINE AMINOTRANSFERASE II INHIBITORS
Descriptor:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-4-{[(1-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, ...
Authors:Dounay, A.B., Anderson, M., Bechle, B.M., Campbell, B.M., Claffey, M.M., Evdokimov, A., Edelweiss, E., Fonseca, K.R., Gan, X., Ghosh, S., Hayward, M.M., Horner, W., Kim, J.Y., McAllister, L.A., Pandit, J., Paradis, V., Parikh, V.D., Reese, M.R., Rong, S.B., Salafia, M.A., Schuyten, K., Strick, C.A., Tuttle, J.B., Valentine, J., Wang, H., Zawadzke, L.E., Verhoest, P.R.
Deposit date:2011-10-28
Release date:2012-02-01
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.
ACS Med Chem Lett, 3, 2012