6N8C
 
 | | Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR | | Descriptor: | Huntingtin | | Authors: | Schwieters, C.D, Kotler, S.A, Schmidt, T, Ceccon, A, Ghirlando, R, Libich, D.S, Clore, G.M. | | Deposit date: | 2018-11-29 | | Release date: | 2019-02-13 | | Last modified: | 2020-01-01 | | Method: | SOLUTION NMR | | Cite: | Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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4ER8
 | | Structure of the REP associates tyrosine transposase bound to a REP hairpin | | Descriptor: | DNA (32-MER), NICKEL (II) ION, TnpArep for protein | | Authors: | Messing, S.A.J, Ton-Hoang, B, Hickman, A.B, Ghirlando, R, Chandler, M, Dyda, F. | | Deposit date: | 2012-04-19 | | Release date: | 2012-08-15 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The processing of repetitive extragenic palindromes: the structure of a repetitive extragenic palindrome bound to its associated nuclease.
Nucleic Acids Res., 40, 2012
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5W7I
 | | X-ray structure of ankyrin repeat domain of DHHC17 in complex with Snap25b peptide | | Descriptor: | Palmitoyltransferase ZDHHC17, Snap25b-111-120 | | Authors: | Verardi, R, Kim, J.-S, Ghirlando, R, Banerjee, A. | | Deposit date: | 2017-06-20 | | Release date: | 2017-08-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.105 Å) | | Cite: | Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.
Structure, 25, 2017
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3RPU
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1YM7
 | | G Protein-Coupled Receptor Kinase 2 (GRK2) | | Descriptor: | Beta-adrenergic receptor kinase 1 | | Authors: | Lodowski, D.T, Barnhill, J.F, Pyskadlo, R.M, Ghirlando, R, Sterne-Marr, R, Tesmer, J.J.G. | | Deposit date: | 2005-01-20 | | Release date: | 2005-07-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (4.5 Å) | | Cite: | The role of Gbetagamma and domain interfaces in the activation of G protein-coupled receptor kinase 2
Biochemistry, 44, 2005
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5W7J
 | | X-ray structure of the E89A variant of ankyrin repeat domain of DHHC17 in complex with Snap25b peptide | | Descriptor: | Palmitoyltransferase ZDHHC17, Snap25b-111-120 | | Authors: | Verardi, R, Kim, J.-S, Ghirlando, R, Banerjee, A. | | Deposit date: | 2017-06-20 | | Release date: | 2017-08-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.
Structure, 25, 2017
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1IB1
 | | CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX | | Descriptor: | 14-3-3 ZETA ISOFORM, COA-S-ACETYL TRYPTAMINE, SEROTONIN N-ACETYLTRANSFERASE | | Authors: | Obsil, T, Ghirlando, R, Klein, D.C, Ganguly, S, Dyda, F. | | Deposit date: | 2001-03-26 | | Release date: | 2001-05-02 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
Cell(Cambridge,Mass.), 105, 2001
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1MN3
 | | Cue domain of yeast Vps9p | | Descriptor: | Vacuolar protein sorting-associated protein VPS9 | | Authors: | Prag, G, Misra, S, Jones, E, Ghirlando, R, Davies, B.A, Horazdovsky, B.F, Hurley, J.H. | | Deposit date: | 2002-09-04 | | Release date: | 2003-06-10 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mechanism of Ubiquitin Recognition by the CUE Domain of Vps9p
Cell(Cambridge,Mass.), 113, 2003
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6B3U
 | | Solution Structure of HIV-1 GP41 Transmembrane Domain in Bicelles | | Descriptor: | HIV-1 GP41 Transmembrane Domain | | Authors: | Chiliveri, S.C, Louis, J.M, Ghirlando, R, Baber, J.L, Bax, A. | | Deposit date: | 2017-09-24 | | Release date: | 2018-01-24 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Tilted, Uninterrupted, Monomeric HIV-1 gp41 Transmembrane Helix from Residual Dipolar Couplings.
J. Am. Chem. Soc., 140, 2018
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2YHH
 | | Microvirin:mannobiose complex | | Descriptor: | MANNAN-BINDING LECTIN, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose | | Authors: | Hussan, S, Bewley, C.A, Clore, G.M, Gustchina, E, Ghirlando, R. | | Deposit date: | 2011-05-02 | | Release date: | 2011-06-15 | | Last modified: | 2020-07-29 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the Monovalent Lectin Microvirin in Complex with Man(Alpha)(1-2)Man Provides a Basis for Anti-HIV Activity with Low Toxicity.
J.Biol.Chem., 286, 2011
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1X9Z
 | | Crystal structure of the MutL C-terminal domain | | Descriptor: | CHLORIDE ION, DNA mismatch repair protein mutL, GLYCEROL, ... | | Authors: | Guarne, A, Ramon-Maiques, S, Wolff, E.M, Ghirlando, R, Hu, X, Miller, J.H, Yang, W. | | Deposit date: | 2004-08-24 | | Release date: | 2004-10-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair
Embo J., 23, 2004
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1XRX
 | | Crystal structure of a DNA-binding protein | | Descriptor: | CALCIUM ION, SeqA protein | | Authors: | Guarne, A, Brendler, T, Zhao, Q, Ghirlando, R, Austin, S, Yang, W. | | Deposit date: | 2004-10-16 | | Release date: | 2005-05-10 | | Last modified: | 2013-03-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of a SeqA-N filament: implications for DNA replication and chromosome organization.
Embo J., 24, 2005
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1P3Q
 | | Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9 | | Descriptor: | Ubiquitin, Vacuolar protein sorting-associated protein VPS9 | | Authors: | Prag, G, Misra, S, Jones, E.A, Ghirlando, R, Davies, B.A, Horazdovsky, B.F, Hurley, J.H. | | Deposit date: | 2003-04-18 | | Release date: | 2003-06-24 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mechanism of Ubiquitin Recognition by the CUE Domain of Vps9p.
Cell(Cambridge,Mass.), 113, 2003
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1RQQ
 | | Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS | | Descriptor: | BISUBSTRATE INHIBITOR, Insulin receptor, MANGANESE (II) ION, ... | | Authors: | Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. | | Deposit date: | 2003-12-06 | | Release date: | 2003-12-30 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
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1RPY
 | | CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS | | Descriptor: | SULFATE ION, adaptor protein APS | | Authors: | Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. | | Deposit date: | 2003-12-03 | | Release date: | 2003-12-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
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2BZF
 | | Structural basis for DNA bridging by barrier-to-autointegration factor (BAF) | | Descriptor: | 5'-D(*CP*CP*TP*CP*CP*AP*CP)-3', 5'-D(*GP*TP*GP*GP*AP*GP*GP)-3', BARRIER-TO-AUTOINTEGRATION FACTOR | | Authors: | Bradley, C.M, Ronning, D.R, Ghirlando, R, Craigie, R, Dyda, F. | | Deposit date: | 2005-08-16 | | Release date: | 2005-09-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | Structural Basis for DNA Bridging by Barrier-to-Autointegration Factor.
Nat.Struct.Mol.Biol., 12, 2005
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3BSU
 | | Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA | | Descriptor: | DNA (5'-D(*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*(5IU)P*DGP*DTP*DC)-3'), MAGNESIUM ION, RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3'), ... | | Authors: | Nowotny, M, Cerritelli, S.M, Ghirlando, R, Gaidamakov, S.A, Crouch, R.J, Yang, W. | | Deposit date: | 2007-12-26 | | Release date: | 2008-03-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.
Embo J., 27, 2008
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3E1R
 | | Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55 | | Descriptor: | Centrosomal protein of 55 kDa, Programmed cell death 6-interacting protein | | Authors: | Lee, H.H, Elia, N, Ghirlando, R, Lippincott-Schwartz, J, Hurley, J.H. | | Deposit date: | 2008-08-04 | | Release date: | 2008-11-04 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.
Science, 322, 2008
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3F1I
 | | Human ESCRT-0 Core Complex | | Descriptor: | Hepatocyte growth factor-regulated tyrosine kinase substrate, Signal transducing adapter molecule 1 | | Authors: | Ren, X, Kloer, D.P, Kim, Y, Ghirlando, R, Saidi, L, Hummer, G, Hurley, J.H. | | Deposit date: | 2008-10-28 | | Release date: | 2009-03-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Hybrid Structural Model of the Complete Human ESCRT-0 Complex.
Structure, 17, 2009
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2QK9
 | | Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid | | Descriptor: | 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*T)-3', 5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', CITRATE ANION, ... | | Authors: | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | | Deposit date: | 2007-07-10 | | Release date: | 2007-11-13 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
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2QKB
 | | Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid | | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', 5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), ... | | Authors: | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | | Deposit date: | 2007-07-10 | | Release date: | 2007-11-13 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
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2QKK
 | | Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', ... | | Authors: | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | | Deposit date: | 2007-07-11 | | Release date: | 2007-11-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
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2A6O
 | | Crystal Structure of the ISHp608 Transposase in Complex with Stem-loop DNA | | Descriptor: | 5'-D(*CP*CP*CP*CP*TP*AP*GP*CP*TP*TP*TP*AP*GP*CP*TP*AP*TP*GP*GP*GP*GP*A)-3', ISHp608 Transposase | | Authors: | Ronning, D.R, Guynet, C, Ton-Hoang, B, Perez, Z.N, Ghirlando, R, Chandler, M, Dyda, F. | | Deposit date: | 2005-07-03 | | Release date: | 2005-10-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Active site sharing and subterminal hairpin recognition in a new class of DNA transposases.
Mol.Cell, 20, 2005
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2A6M
 | | Crystal Structure of the ISHp608 Transposase | | Descriptor: | ISHp608 transposase | | Authors: | Ronning, D.R, Guynet, C, Ton-Hoang, B, Perez, Z.N, Ghirlando, R, Chandler, M, Dyda, F. | | Deposit date: | 2005-07-03 | | Release date: | 2005-10-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Active site sharing and subterminal hairpin recognition in a new class of DNA transposases.
Mol.Cell, 20, 2005
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2AOR
 | | Crystal structure of MutH-hemimethylated DNA complex | | Descriptor: | 5'-D(*CP*AP*GP*GP*(6MA)P*TP*CP*CP*AP*AP*GP*CP*TP*TP*GP*GP*AP*TP*CP*CP*TP*G)-3', CALCIUM ION, DNA mismatch repair protein mutH | | Authors: | Lee, J.Y, Chang, J, Joseph, N, Ghirlando, R, Rao, D.N, Yang, W. | | Deposit date: | 2005-08-13 | | Release date: | 2005-10-11 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | MutH complexed with hemi- and unmethylated DNAs: coupling base recognition and DNA cleavage.
Mol.Cell, 20, 2005
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