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4O1Z
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CRYSTAL STRUCTURE OF OVINE CYCLOOXYGENASE-1 COMPLEX WITH MELOXICAM
Descriptor:Prostaglandin G/H synthase 1, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, S., Hermanson, D.J., Banerjee, S., Ghebreselasie, K., Clayton, G.M., Garavito, R.M., Marnett, L.J.
Deposit date:2013-12-16
Release date:2014-01-22
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
J.Biol.Chem., 289, 2014
4M10
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CRYSTAL STRUCTURE OF MURINE CYCLOOXYGENASE-2 COMPLEX WITH ISOXICAM
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Xu, S., Hermanson, D.J., Banerjee, S., Ghebreelasie, K., Marnett, L.J.
Deposit date:2013-08-02
Release date:2014-01-22
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
J.Biol.Chem., 289, 2014
6BL3
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CRYSTAL COMPLEX OF CYCLOOXYGENASE-2 WITH INDOMETHACIN-BUTYLDIAMINE-DANSYL CONJUGATE
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.
Deposit date:2017-11-09
Release date:2018-11-14
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.217 Å)
Cite:Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.
J.Biol.Chem., 294, 2019
6BL4
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CRYSTAL COMPLEX OF CYCLOOXYGENASE-2 WITH INDOMETHACIN-ETHYLENEDIAMINE-DANSYL CONJUGATE
Descriptor:Prostaglandin G/H synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.
Deposit date:2017-11-09
Release date:2018-11-14
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.
J.Biol.Chem., 294, 2019
4M11
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CRYSTAL STRUCTURE OF MURINE CYCLOOXYGENASE-2 COMPLEX WITH MELOXICAM
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Xu, S., Banerjee, S., Hermanson, D.J., Marnett, L.J.
Deposit date:2013-08-02
Release date:2014-01-22
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
J.Biol.Chem., 289, 2014
4OTJ
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THE COMPLEX OF MURINE CYCLOOXYGENASE-2 WITH A CONJUGATE OF INDOMEFATHIN AND PODOPHYLLOTOXIN, N-{(SUCCINYLPODOPHYLLOTOXINYL)BUT-4-YL}-2-{1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL}ACETAMIDE
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.
Deposit date:2014-02-13
Release date:2015-04-08
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.
Acs Chem.Biol., 11, 2016
4RRW
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CRYSTAL STRUCTURE OF APO MURINE CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRX
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CRYSTAL STRUCTURE OF APO MURINE V89W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRY
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.429 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRZ
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RS0
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CRYSTAL STRUCTURE OF MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH S-IBUPROFEN
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4Z0L
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THE MURINE CYCLOOXYGENASE-2 COMPLEXED WITH A NIDO-DICARBABORATE-CONTAINING INDOMETHACIN DERIVATIVE
Descriptor:Prostaglandin G/H synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, S., Neumann, W., Banerjee, S., Hey-Hawkins, E., Marnett, L.J.
Deposit date:2015-03-26
Release date:2015-06-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.
Chemmedchem, 11, 2016
5W58
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CRYSTAL COMPLEX OF CYCLOOXYGENASE-2: (S)-ARN-2508 (A DUAL COX AND FAAH INHIBITOR)
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Goodman, M.C., Banerjee, S., Piomelli, D., Marnett, L.J.
Deposit date:2017-06-14
Release date:2018-01-31
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.267 Å)
Cite:Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
J. Biol. Chem., 293, 2018