Author results

6HEM
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STRUCTURE OF THE C-TERMINAL DOMAIN OF USP25 (748-1048)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 25, GLYCEROL, SODIUM ION
Authors:Gersch, M., Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 2019
6HEL
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STRUCTURE OF HUMAN USP25
Descriptor:Ubiquitin carboxyl-terminal hydrolase 25
Authors:Gersch, M., Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.941 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 2019
6HEK
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STRUCTURE OF HUMAN USP28 BOUND TO UBIQUITIN-PA
Descriptor:Ubiquitin carboxyl-terminal hydrolase 28, Polyubiquitin-B, TETRAETHYLENE GLYCOL, ...
Authors:Gersch, M., Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 2019
6HEJ
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STRUCTURE OF HUMAN USP28
Descriptor:Ubiquitin carboxyl-terminal hydrolase 28, SULFATE ION
Authors:Gersch, M., Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 2019
6HEI
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STRUCTURE OF THE CATALYTIC DOMAIN OF USP28 (INSERTION DELETED) BOUND TO UBIQUITIN-PA
Descriptor:Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28, Polyubiquitin-B, 1,2-ETHANEDIOL
Authors:Gersch, M., Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 2019
6HEH
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STRUCTURE OF THE CATALYTIC DOMAIN OF USP28 (INSERTION DELETED)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Gersch, M., Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 2019
6H23
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CRYSTAL STRUCTURE OF THE HCLPP Y118A MUTANT WITH AN ACTIVATING SMALL MOLECULE
Descriptor:ATP-dependent Clp protease proteolytic subunit, mitochondrial, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-[(2-chloranyl-4-fluoranyl-phenyl)methyl]-1,3,4-oxadiazole-2-carboxamide, ...
Authors:Kick, L.M., Sieber, S.A., Schneider, S.
Deposit date:2018-07-13
Release date:2018-08-29
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.089 Å)
Cite:Selective Activation of Human Caseinolytic Protease P (ClpP).
Angew. Chem. Int. Ed. Engl., 57, 2018
6CFD
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ADEP4 BOUND TO E. FAECIUM CLPP
Descriptor:ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide
Authors:Lee, R.E., Griffith, E.C.
Deposit date:2018-02-14
Release date:2018-05-16
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci.
Antimicrob. Agents Chemother., 62, 2018
5W18
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STAPHYLOCOCCUS AUREUS CLPP IN COMPLEX WITH (S)-N-((2R,6S,8AS,14AS,20S,23AS)-2,6-DIMETHYL-5,8,14,19,23-PENTAOXOOCTADECAHYDRO-1H,5H,14H,19H-PYRIDO[2,1-I]DIPYRROLO[2,1-C:2',1'-L][1]OXA[4,7,10,13]TETRAAZACYCLOHEXADECIN-20-YL)-3-PHENYL-2-(3-PHENYLUREIDO)PROPANAMIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, 9V7-PHE-SER-PRO-YCP-ALA-MP8
Authors:Lee, R.E., Griffith, E.C.
Deposit date:2017-06-02
Release date:2017-08-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Design and Synthesis of Urea Depsipeptide as ClpP Activators
To Be Published
5VZ2
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STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH ACYLDEPSIPEPTIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, Acyldepsipeptide
Authors:Griffith, E.C., Lee, R.E.
Deposit date:2017-05-26
Release date:2017-06-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Design and Synthesis of Urea Depsipeptides as ClpP Activators
To Be Published
5OHP
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CRYSTAL STRUCTURE OF USP30 (C77A) IN COMPLEX WITH LYS6-LINKED DIUBIQUITIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 30, Polyubiquitin-B, ZINC ION
Authors:Gersch, M., Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
5OHN
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CRYSTAL STRUCTURE OF USP30 IN COVALENT COMPLEX WITH UBIQUITIN PROPARGYLAMIDE (LOW RESOLUTION)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, Polyubiquitin-B, ZINC ION
Authors:Gersch, M., Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
5OHK
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CRYSTAL STRUCTURE OF USP30 IN COVALENT COMPLEX WITH UBIQUITIN PROPARGYLAMIDE (HIGH RESOLUTION)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, Polyubiquitin-B, ZINC ION, ...
Authors:Gersch, M., Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
5NGF
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE COVALENT INHIBITOR, FT827
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide, 1,2-ETHANEDIOL
Authors:Krajewski, W.W., Turnbull, A.P., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5NGE
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE NON-COVALENT INHIBITOR, FT671
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
Authors:Turnbull, A.P., Krajewski, W.W., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5LRX
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STRUCTURE OF A20 OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:Tumor necrosis factor alpha-induced protein 3, Polyubiquitin-B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRW
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, GLYCEROL
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRV
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO LYS11-LINKED DIUBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, PHOSPHATE ION, ...
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRU
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN
Descriptor:OTU domain-containing protein 7B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
4WZP
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SER65 PHOSPHORYLATED UBIQUITIN, MAJOR CONFORMATION
Descriptor:ubiquitin, SULFATE ION
Authors:Wauer, T., Wagstaff, J., Freund, S.M.V., Komander, D.
Deposit date:2014-11-20
Release date:2015-01-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
Embo J., 34, 2015
4R18
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LIGAND-INDUCED LYS33-THR1 CROSSLINKING AT SUBUNIT BETA5 OF THE YEAST 20S PROTEASOME
Descriptor:PROTEASOME SUBUNIT ALPHA TYPE-2, PROTEASOME SUBUNIT ALPHA TYPE-3, PROTEASOME SUBUNIT ALPHA TYPE-4, ...
Authors:Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krueger, A., Liskamp, R., Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
4R17
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LIGAND-INDUCED AZIRIDINE-FORMATION AT SUBUNIT BETA5 OF THE YEAST 20S PROTEASOME
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krueger, A., Liskamp, R., Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MXI
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CLPP SER98DHA
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Gersch, M., Kolb, R., Alte, F., Groll, M., Sieber, S.A.
Deposit date:2013-09-26
Release date:2013-10-23
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition.
J.Am.Chem.Soc., 136, 2014
4JCT
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CLPP2 FROM LISTERIA MONOCYTOGENES
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Groll, M., Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCR
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CLPP1 N165D MUTANT FROM LISTERIA MONOCYTOGENES
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Groll, M., Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
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