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4R52
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BU of 4r52 by Molmil
1.5 angstrom crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION
Authors:Geng, J, Gumpper, R.H, Huo, L, Liu, A.
Deposit date:2014-08-20
Release date:2016-03-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:1.5 angstrom crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans
To be Published
6LQI
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BU of 6lqi by Molmil
Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1
Descriptor: Piezo-type mechanosensitive ion channel component 1
Authors:Geng, J, Liu, W, Zhou, H, Zhang, T, Wang, L, Zhang, M, Shen, B, Li, X, Xiao, B.
Deposit date:2020-01-13
Release date:2020-03-04
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.
Neuron, 106, 2020
2QYK
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BU of 2qyk by Molmil
Crystal structure of PDE4A10 in complex with inhibitor NPV
Descriptor: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, Cyclic AMP-specific phosphodiesterase HSPDE4A10, MAGNESIUM ION, ...
Authors:Wang, H, Peng, M, Chen, Y, Geng, J, Robinson, H, Houslay, M.
Deposit date:2007-08-15
Release date:2008-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
2R8Q
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BU of 2r8q by Molmil
Structure of LmjPDEB1 in complex with IBMX
Descriptor: 3-ISOBUTYL-1-METHYLXANTHINE, Class I phosphodiesterase PDEB1, MAGNESIUM ION, ...
Authors:Wang, H, Yan, Z, Geng, J, Kunz, S, Seebeck, T, Ke, H.
Deposit date:2007-09-11
Release date:2007-12-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors.
Mol.Microbiol., 66, 2007
5Z10
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BU of 5z10 by Molmil
Structure of the mechanosensitive Piezo1 channel
Descriptor: Piezo-type mechanosensitive ion channel component 1
Authors:Zhao, Q, Zhou, H, Chi, S, Wang, Y, Wang, J, Geng, J, Wu, K, Liu, W, Zhang, T, Dong, M.-Q, Wang, J, Li, X, Xiao, B.
Deposit date:2017-12-22
Release date:2018-01-31
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structure and mechanogating mechanism of the Piezo1 channel.
Nature, 554, 2018
7KQ2
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BU of 7kq2 by Molmil
1.98 A resolution crystal structure of Group A Streptococcus H111A HupZ-V5-His6
Descriptor: GLYCEROL, HupZ, SULFATE ION
Authors:Traore, E, Li, J, Liu, A.
Deposit date:2020-11-13
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:Heme Binding to HupZ with a C-Terminal Tag from Group A Streptococcus.
Molecules, 26, 2021
7KPZ
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BU of 7kpz by Molmil
1.70 A resolution crystal structure of Group A Streptococcus HupZ-V5-His6
Descriptor: HupZ
Authors:Li, J, Liu, A.
Deposit date:2020-11-13
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Heme Binding to HupZ with a C-Terminal Tag from Group A Streptococcus.
Molecules, 26, 2021
1XNN
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BU of 1xnn by Molmil
CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT COMPLEX WITH (3A-ALPHA-,4-ALPHA 7-ALPHA-,7A-ALPHA-)-3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE.
Descriptor: Androgen receptor, REL-(3AR,4S,7R,7AS)-3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
Authors:Sack, J.
Deposit date:2004-10-05
Release date:2005-10-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.
Bioorg.Med.Chem.Lett., 15, 2005
5DH3
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BU of 5dh3 by Molmil
Crystal structure of MST2 in complex with XMU-MP-1
Descriptor: 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, SULFATE ION, ...
Authors:Kong, L.L, Yun, C.H.
Deposit date:2015-08-29
Release date:2016-08-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.468 Å)
Cite:Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Sci Transl Med, 8, 2016
2QYL
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BU of 2qyl by Molmil
Crystal structure of PDE4B2B in complex with inhibitor NPV
Descriptor: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, MAGNESIUM ION, Phosphodiesterase 4B, ...
Authors:Ke, H.
Deposit date:2007-08-15
Release date:2008-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
2QYM
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BU of 2qym by Molmil
crystal structure of unliganded PDE4C2
Descriptor: MAGNESIUM ION, Phosphodiesterase 4C, ZINC ION
Authors:Ke, H.
Deposit date:2007-08-15
Release date:2008-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
2QYN
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BU of 2qyn by Molmil
Crystal structure of PDE4D2 in complex with inhibitor NPV
Descriptor: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, MAGNESIUM ION, ZINC ION, ...
Authors:Ke, H.
Deposit date:2007-08-15
Release date:2008-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
3RLM
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BU of 3rlm by Molmil
Structure of the W199F MauG/pre-Methylamine Dehydrogenase complex after treatment with hydrogen peroxide
Descriptor: ACETATE ION, CALCIUM ION, HEME C, ...
Authors:Yukl, E.T, Wilmot, C.M.
Deposit date:2011-04-19
Release date:2011-10-05
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RMZ
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BU of 3rmz by Molmil
Crystal Structure of the W199F-MauG/pre-Methylamine Dehydrogenase Complex
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, ...
Authors:Jensen, L.M.R, Wilmot, C.M.
Deposit date:2011-04-21
Release date:2011-10-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RN0
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BU of 3rn0 by Molmil
Crystal Structure of the W199K-MauG/pre-Methylamine Dehydrogenase Complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, HEME C, ...
Authors:Jensen, L.M.R, Wilmot, C.M.
Deposit date:2011-04-21
Release date:2011-10-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
5ZUG
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BU of 5zug by Molmil
Structure of the bacterial acetate channel SatP
Descriptor: Succinate-acetate/proton symporter SatP, nonyl beta-D-glucopyranoside
Authors:Sun, P.C, Li, J.L, Xiao, Q.J, Guan, Z.Y, Deng, D.
Deposit date:2018-05-07
Release date:2018-11-21
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Crystal structure of the bacterial acetate transporter SatP reveals that it forms a hexameric channel.
J. Biol. Chem., 293, 2018
6LTO
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BU of 6lto by Molmil
cryo-EM structure of full length human Pannexin1
Descriptor: Pannexin-1
Authors:Mou, L.Q, Ke, M, Xiao, Q.J, Wu, J.P, Deng, D.
Deposit date:2020-01-23
Release date:2020-05-13
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for gating mechanism of Pannexin 1 channel.
Cell Res., 30, 2020
6LTN
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BU of 6ltn by Molmil
cryo-EM structure of C-terminal truncated human Pannexin1
Descriptor: Pannexin-1
Authors:Mou, L.Q, Ke, M, Xiao, Q.J, Wu, J.P, Deng, D.
Deposit date:2020-01-23
Release date:2020-05-13
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for gating mechanism of Pannexin 1 channel.
Cell Res., 30, 2020
6KXA
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BU of 6kxa by Molmil
Galectin-3 CRD binds to GalA dimer
Descriptor: Galectin-3, alpha-D-galactopyranuronic acid-(1-4)-beta-D-galactopyranuronic acid
Authors:Su, J.
Deposit date:2019-09-10
Release date:2020-08-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Topsy-turvy binding of negatively charged homogalacturonan oligosaccharides to galectin-3.
Glycobiology, 31, 2021
6KXB
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BU of 6kxb by Molmil
Galectin-3 CRD binds to GalA trimer
Descriptor: Galectin-3, alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-beta-D-galactopyranuronic acid
Authors:Su, J.
Deposit date:2019-09-10
Release date:2020-08-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Topsy-turvy binding of negatively charged homogalacturonan oligosaccharides to galectin-3.
Glycobiology, 31, 2021
4O91
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BU of 4o91 by Molmil
Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1
Descriptor: Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
Authors:Gurbani, D, Hunter, J.C, Tan, L, Westover, K.D.
Deposit date:2013-12-31
Release date:2014-07-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2).
J.Med.Chem., 58, 2015
4HVO
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BU of 4hvo by Molmil
1.75 angstrom x-ray crystal structure of cufe reconstituted 3-hydroxyanthranilate-3,4-dioxygenase from cupriavidus metallidurans
Descriptor: 3-hydroxyanthranilate 3,4-dioxygenase, COPPER (II) ION, FE (II) ION
Authors:Liu, F, Chen, L, Liu, A.
Deposit date:2012-11-06
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
4HVQ
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BU of 4hvq by Molmil
X-ray crystal structure of FECU reconstituted 3-hydroxyanthranilate-3,4-dioxygenase from cupriavidus metallidurans
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION
Authors:Liu, F, Chen, L, Liu, A.
Deposit date:2012-11-06
Release date:2013-11-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
4HSJ
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BU of 4hsj by Molmil
1.88 angstrom x-ray crystal structure of piconlinic-bound 3-hydroxyanthranilate-3,4-dioxygenase
Descriptor: 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION, PYRIDINE-2-CARBOXYLIC ACID
Authors:Liu, F, Chen, L, Davis, C.I, Liu, A.
Deposit date:2012-10-30
Release date:2015-05-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.883 Å)
Cite:An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
7E26
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BU of 7e26 by Molmil
Structure of PfFNT in apo state
Descriptor: Formate-nitrite transporter
Authors:Yan, C.Y, Jiang, X, Deng, D, Peng, X, Wang, N, Zhu, A, Xu, H, Li, J.
Deposit date:2021-02-04
Release date:2021-08-18
Last modified:2023-05-17
Method:ELECTRON MICROSCOPY (2.29 Å)
Cite:Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.
Plos Biol., 19, 2021

 

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