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1YN3
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BU of 1yn3 by Molmil
Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens
Descriptor: truncated cell surface protein map-w
Authors:Geisbrecht, B.V, Hamaoka, B.Y, Perman, B, Zemla, A, Leahy, D.J.
Deposit date:2005-01-23
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens.
J.Biol.Chem., 280, 2005
1YN4
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BU of 1yn4 by Molmil
Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens
Descriptor: EapH1, ZINC ION
Authors:Geisbrecht, B.V, Hamaoka, B.Y, Perman, B, Zemla, A, Leahy, D.J.
Deposit date:2005-01-23
Release date:2005-03-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens.
J.Biol.Chem., 280, 2005
1YN5
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BU of 1yn5 by Molmil
Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens
Descriptor: EapH2
Authors:Geisbrecht, B.V, Hamaoka, B.Y, Perman, B, Zemla, A, Leahy, D.J.
Deposit date:2005-01-23
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens.
J.Biol.Chem., 280, 2005
3D5R
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BU of 3d5r by Molmil
Crystal Structure of Efb-C (N138A) / C3d Complex
Descriptor: Complement C3, Fibrinogen-binding protein
Authors:Geisbrecht, B.V.
Deposit date:2008-05-16
Release date:2008-09-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d.
Protein Sci., 17, 2008
3D5S
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BU of 3d5s by Molmil
Crystal Structure of Efb-C (R131A) / C3d Complex
Descriptor: Complement C3, Fibrinogen-binding protein
Authors:Geisbrecht, B.V.
Deposit date:2008-05-16
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d.
Protein Sci., 17, 2008
8TYP
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BU of 8typ by Molmil
Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide
Descriptor: 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Geisbrecht, B.V.
Deposit date:2023-08-25
Release date:2023-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs.
J Immunol., 212, 2024
7TE3
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BU of 7te3 by Molmil
Crystal Structure of a Double Loop Deletion Mutant in gC1qR/C1qBP/HABP-1
Descriptor: Complement component 1 Q subcomponent-binding protein, mitochondrial
Authors:Geisbrecht, B.V.
Deposit date:2022-01-04
Release date:2022-06-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII.
Front Immunol, 13, 2022
3L3O
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BU of 3l3o by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3c
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V, Garcia, B.G.
Deposit date:2009-12-17
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3KS2
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BU of 3ks2 by Molmil
Crystal Structure of Type-III Secretion Chaperone IpgC from Shigella flexneri (residues 10-155)
Descriptor: Chaperone protein ipgC
Authors:Geisbrecht, B.V, Barta, M.L.
Deposit date:2009-11-20
Release date:2010-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone
Bmc Struct.Biol., 10, 2010
3L5N
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BU of 3l5n by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor, ...
Authors:Geisbrecht, B.V, Garcia, B.L.
Deposit date:2009-12-22
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (7.536 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3NMS
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BU of 3nms by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement C3c
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V, Garcia, B.L.
Deposit date:2010-06-22
Release date:2010-08-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3OHX
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BU of 3ohx by Molmil
Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V, Garcia, B.L.
Deposit date:2010-08-18
Release date:2010-09-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
6D69
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BU of 6d69 by Molmil
Crystal Structure of the NHL Repeat Region of D. melanogaster Thin
Descriptor: GLYCEROL, NHL Repeat Region of D. melanogaster Thin
Authors:Ramyar, K.X, McWhorter, W.J, Geisbrecht, B.V.
Deposit date:2018-04-20
Release date:2019-04-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:DrosophilaTRIM32 cooperates with glycolytic enzymes to promote cell growth.
Elife, 9, 2020
1FCH
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BU of 1fch by Molmil
CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE TPR REGION OF HUMAN PEX5
Descriptor: PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR, PTS1-CONTAINING PEPTIDE
Authors:Gatto Jr, G.J, Geisbrecht, B.V, Gould, S.J, Berg, J.M.
Deposit date:2000-07-18
Release date:2000-12-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5.
Nat.Struct.Biol., 7, 2000
6VTM
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BU of 6vtm by Molmil
Human Cathepsin-G Inhibited by S. aureus EapH1
Descriptor: Cathepsin G, MAP domain-containing protein, SULFATE ION
Authors:Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2020-02-13
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Human Cathepsin-G Inhibited by S. aureus EapH1
J.Biol.Chem., 2020
5JXU
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BU of 5jxu by Molmil
Structural basis for the catalytic activity of Thermomonospora curvata heme-containing DyP-type peroxidase.
Descriptor: Dyp-type peroxidase family, PROTOPORPHYRIN IX CONTAINING FE
Authors:Ramyar, K.X, Carlson, E.A, Li, P, Geisbrecht, B.V.
Deposit date:2016-05-13
Release date:2016-10-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Identification of Surface-Exposed Protein Radicals and A Substrate Oxidation Site in A-Class Dye-Decolorizing Peroxidase from Thermomonospora curvata.
ACS Catal, 6, 2016
8TE6
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BU of 8te6 by Molmil
Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
Descriptor: V-set and immunoglobulin domain-containing protein 4
Authors:Abram, T.G, Geisbrecht, B.V.
Deposit date:2023-07-05
Release date:2023-07-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.251 Å)
Cite:New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants.
Immunohorizons, 7, 2023
8TE5
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BU of 8te5 by Molmil
Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
Descriptor: V-set and immunoglobulin domain-containing protein 4
Authors:Abram, T.G, Geisbrecht, B.V.
Deposit date:2023-07-05
Release date:2023-07-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants.
Immunohorizons, 7, 2023
2HHI
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BU of 2hhi by Molmil
The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a novel class of beta-grasp proteins
Descriptor: Immunogenic protein MPT64
Authors:Wang, Z, Potter, B.M, Gray, A.M, Sacksteder, K.A, Geisbrecht, B.V, Laity, J.H.
Deposit date:2006-06-28
Release date:2006-12-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Solution Structure of Antigen MPT64 from Mycobacterium tuberculosis Defines a New Family of Beta-Grasp Proteins.
J.Mol.Biol., 366, 2007
7JTN
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BU of 7jtn by Molmil
Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 29 Bases
Descriptor: Complement factor B, DNA (30-MER)
Authors:Xu, X, Geisbrecht, B.V.
Deposit date:2020-08-18
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
J Immunol., 206, 2021
7JTQ
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BU of 7jtq by Molmil
Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 31 Bases
Descriptor: Complement factor B, DNA (32-MER)
Authors:Xu, X, Geisbrecht, B.V.
Deposit date:2020-08-18
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
J Immunol., 206, 2021
6AZP
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BU of 6azp by Molmil
A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase Inhibitor (SPIN)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Ramyar, K.X, Geisbrecht, B.V.
Deposit date:2017-09-11
Release date:2017-12-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).
J. Biol. Chem., 293, 2018
6BMT
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BU of 6bmt by Molmil
Crystal Structure of a Recombinant form of Human Myeloperoxidase Bound to an Inhibitor from Staphylococcus delphini
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Ploscariu, N.T, Geisbrecht, B.V.
Deposit date:2017-11-15
Release date:2018-01-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini.
Arch. Biochem. Biophys., 645, 2018
1SZH
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BU of 1szh by Molmil
Crystal Structure of C. elegans HER-1
Descriptor: ACETATE ION, Her-1 protein
Authors:Hamaoka, B.Y, Dann III, C.E, Geisbrecht, B.V, Leahy, D.J.
Deposit date:2004-04-05
Release date:2004-08-10
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Proc.Natl.Acad.Sci.USA, 101, 2004
4NZL
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BU of 4nzl by Molmil
Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases
Descriptor: Neutrophil elastase, Uncharacterized protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stapels, D.A.C, von Koeckritz-Blickwede, M, Ramyar, K.X, Bischoff, M, Milder, F, Ruyken, M, Scheepmaker, L, McWhorter, W.J, Herrmann, M, van Kessel, K.P.M, Geisbrecht, B.V, Rooijakkers, S.H.M.
Deposit date:2013-12-12
Release date:2014-08-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014

 

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