Author results

2AN3
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STRUCTURE OF PNMT WITH S-ADENOSYL-L-HOMOCYSTEINE AND THE SEMI-RIGID ANALOGUE ACCEPTOR SUBSTRATE CIS-(1R,2S)-2-AMINO-1-TETRALOL.
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
Authors:Gee, C.L., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., McLeish, M.J., Martin, J.L.
Deposit date:2005-08-11
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
2AN4
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STRUCTURE OF PNMT COMPLEXED WITH S-ADENOSYL-L-HOMOCYSTEINE AND THE ACCEPTOR SUBSTRATE OCTOPAMINE
Descriptor:Phenylethanolamine N-methyltransferase, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Gee, C.L., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., McLeish, M.J., Martin, J.L.
Deposit date:2005-08-11
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
2AN5
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STRUCTURE OF HUMAN PNMT COMPLEXED WITH S-ADENOSYL-HOMOCYSTEINE AND AN INHIBITOR, TRANS-(1S,2S)-2-AMINO-1-TETRALOL
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL, ...
Authors:Gee, C.L., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., McLeish, M.J., Martin, J.L.
Deposit date:2005-08-11
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
3OTV
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CRYSTAL STRUCTURE OF THE INTRACELLULAR DOMAIN OF RV3910 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
Authors:Gee, C.L., Alber, T.
Deposit date:2010-09-14
Release date:2012-02-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.094 Å)
Cite:A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria
Sci.Signal., 5, 2012
3OUK
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CRYSTAL STRUCTURE OF RV3910 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
Authors:Gee, C.L., Alber, T.
Deposit date:2010-09-15
Release date:2012-02-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.402 Å)
Cite:A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria
Sci.Signal., 5, 2012
3OUN
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CRYSTAL STRUCTURE OF THE FHAA FHA DOMAIN COMPLEXED WITH THE INTRACELLULAR DOMAIN OF RV3910
Descriptor:Putative uncharacterized protein TB39.8, PROBABLE CONSERVED TRANSMEMBRANE PROTEIN, MANGANESE (II) ION
Authors:Gee, C.L., Alber, T.
Deposit date:2010-09-15
Release date:2012-02-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.705 Å)
Cite:A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria
Sci.Signal., 5, 2012
2G70
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STRUCTURE OF HUMAN PNMT IN COMPLEX WITH INHIBITOR 3-HYDROXYMETHYL-7-NITRO-THIQ AND ADOMET (SAM)
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE, [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL, ...
Authors:Tyndall, J.D.A., Gee, C.L., Martin, J.L.
Deposit date:2006-02-27
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
J.Med.Chem., 50, 2007
2G71
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STRUCTURE OF HPNMT WITH INHIBITOR 3-FLUOROMETHYL-7-TRIFLUOROPROPYL-THIQ AND ADOHCY
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, ...
Authors:Tyndall, J.D.A., Gee, C.L., Martin, J.L.
Deposit date:2006-02-27
Release date:2007-02-13
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
J.Med.Chem., 50, 2007
2G72
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STRUCTURE OF HPNMT WITH INHIBITOR 3-FLUOROMETHYL-7-THIOMORPHOLINOSULFONAMIDE-THIQ AND ADOMET
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE, (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
Authors:Tyndall, J.D.A., Gee, C.L., Martin, J.L.
Deposit date:2006-02-27
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
J.Med.Chem., 50, 2007
3SBO
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STRUCTURE OF E.COLI GDH FROM NATIVE SOURCE
Descriptor:NADP-specific glutamate dehydrogenase, CHLORIDE ION
Authors:Gee, C.L., Zubieta, C., Echols, N., Totir, M.
Deposit date:2011-06-06
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.204 Å)
Cite:Macro-to-Micro Structural Proteomics: Native Source Proteins for High-Throughput Crystallization.
Plos One, 7, 2012
3UQC
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STRUCTURE OF THE INTRACELLULAR KINASE HOMOLOGY DOMAIN OF RV3910 AT 2.2 A RESOLUTION
Descriptor:PROBABLE CONSERVED TRANSMEMBRANE PROTEIN, SUCCINIC ACID
Authors:Alber, T., Gee, C.L., Blair, S.R., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-11-20
Release date:2012-02-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.256 Å)
Cite:A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.
Sci.Signal., 5, 2012
1YZ3
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STRUCTURE OF HUMAN PNMT COMPLEXED WITH COFACTOR PRODUCT ADOHCY AND INHIBITOR SK&F 64139
Descriptor:Phenylethanolamine N-methyltransferase, 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Wu, Q., Gee, C.L., Lin, F., Martin, J.L., Grunewald, G.L., McLeish, M.J.
Deposit date:2005-02-27
Release date:2006-02-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
J.Med.Chem., 48, 2005
2G8N
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STRUCTURE OF HPNMT WITH INHIBITOR 3-HYDROXYMETHYL-7-(N-4-CHLOROPHENYLAMINOSULFONYL)-THIQ AND ADOHCY
Descriptor:Phenylethanolamine N-methyltransferase, (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Drinkwater, N., Gee, C.L., Martin, J.L.
Deposit date:2006-03-02
Release date:2006-09-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase
J.Med.Chem., 49, 2006
2OZ5
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PROTEIN TYROSINE PHOSPHATASE PTPB IN COMPLEX WITH THE SPECIFIC INHIBITOR OMTS
Descriptor:Phosphotyrosine protein phosphatase ptpb, {(3-CHLOROBENZYL)[(5-{[(3,3-DIPHENYLPROPYL)AMINO]SULFONYL}-2-THIENYL)METHYL]AMINO}(OXO)ACETIC ACID
Authors:Grundner, C., Gee, C.L., Alber, T., TB Structural Genomics Consortium (TBSGC)
Deposit date:2007-02-23
Release date:2007-05-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB.
Structure, 15, 2007
2XHY
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CRYSTAL STRUCTURE OF E.COLI BGLA
Descriptor:6-PHOSPHO-BETA-GLUCOSIDASE BGLA, BROMIDE ION, SULFATE ION
Authors:Totir, M., Zubieta, C., Echols, N., May, A.P., Gee, C.L., nanao, M., alber, T.
Deposit date:2010-06-24
Release date:2011-07-06
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Macro-to-Micro Structural Proteomics: Native Source Proteins for High-Throughput Crystallization.
Plos One, 7, 2012
3HCB
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CRYSTAL STRUCTURE OF HPNMT IN COMPLEX WITH NORADRENOCHROME AND ADOHCY
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (3S)-3-hydroxy-2,3-dihydro-1H-indole-5,6-dione
Authors:Drinkwater, N., Martin, J.L., Gee, C.L.
Deposit date:2009-05-06
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.
Biochem.J., 422, 2009
3HCC
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CRYSTAL STRUCTURE OF HPNMT IN COMPLEX WITH ANTI-9-AMINO-5-(TRIFLUROMETHYL) BENZONORBORNENE AND ADOHCY
Descriptor:Phenylethanolamine N-methyltransferase, (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Drinkwater, N., Martin, J.L., Gee, C.L., Puri, M.
Deposit date:2009-05-06
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.
Biochem.J., 422, 2009
4KH3
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STRUCTURE OF A BACTERIAL SELF-ASSOCIATING PROTEIN
Descriptor:Antigen 43, MALONATE ION
Authors:Heras, B., Gee, C.L., Schembri, M.A., Totsika, M.
Deposit date:2013-04-30
Release date:2014-01-15
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping.
Proc.Natl.Acad.Sci.USA, 111, 2014
5IG0
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CRYSTAL STRUCTURE OF S. ROSETTA CAMKII HUB
Descriptor:CAMK/CAMK2 protein kinase, SULFATE ION, GLYCEROL
Authors:Bhattacharyya, M., Gee, C.L., Barros, T., Kuriyan, J.
Deposit date:2016-02-26
Release date:2016-03-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.
Elife, 5, 2016
5IG1
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CRYSTAL STRUCTURE OF S. ROSETTA CAMKII KINASE DOMAIN
Descriptor:CAMK/CAMK2 protein kinase, PHOSPHATE ION
Authors:Bhattacharyya, M., Gee, C.L., Barros, T., Kuriyan, J.
Deposit date:2016-02-26
Release date:2016-03-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.
Elife, 5, 2016
5IG3
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CRYSTAL STRUCTURE OF THE HUMAN CAMKII-ALPHA HUB
Descriptor:Calcium/calmodulin-dependent protein kinase type II subunit alpha
Authors:McSpadden, E., Cao, Y.M., Bhattacharyya, M., Gee, C.L., Barros, T., Kuriyan, J.
Deposit date:2016-02-26
Release date:2016-03-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.
Elife, 5, 2016
5IG4
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CRYSTAL STRUCTURE OF N. VECTENSIS CAMKII-A HUB
Descriptor:Predicted protein, GLYCEROL
Authors:Bhattacharyya, M., Pappireddi, N., Gee, C.L., Barros, T., Kuriyan, J.
Deposit date:2016-02-26
Release date:2016-03-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.
Elife, 5, 2016
5IG5
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CRYSTAL STRUCTURE OF N. VECTENSIS CAMKII-B HUB AT PH 4.2
Descriptor:CaMKII-B hub
Authors:Bhattacharyya, M., Gee, C.L., Barros, T., Kuriyan, J.
Deposit date:2016-02-26
Release date:2016-03-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.
Elife, 5, 2016
5WDO
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H-RAS BOUND TO GMP-PNP AT 277K
Descriptor:GTPase HRas, CALCIUM ION, MAGNESIUM ION, ...
Authors:Cofsky, J.C., Bandaru, P., Gee, C.L., Kuriyan, J.
Deposit date:2017-07-05
Release date:2017-07-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
5WDP
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H-RAS MUTANT L120A BOUND TO GMP-PNP AT 277K
Descriptor:GTPase HRas, CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Cofsky, J.C., Bandaru, P., Gee, C.L., Kuriyan, J.
Deposit date:2017-07-05
Release date:2017-07-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
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