Author results

6F4Q
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HUMAN JMJD5 (Q275C) IN COMPLEX WITH MN(II), NOG AND RPS6-A138C (129-144) (COMPLEX-2)
Descriptor:JmjC domain-containing protein 5, 40S ribosomal protein S6, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
4CQH
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STRUCTURE OF INFRARED FLUORESCENT PROTEIN IFP2.0
Descriptor:BACTERIOPHYTOCHROME, 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium-2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, SODIUM ION
Authors:Lafaye, C., Yu, D., Noirclerc-Savoye, M., Shu, X., Royant, A.
Deposit date:2014-02-17
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:An Improved Monomeric Infrared Fluorescent Protein for Neuronal and Tumour Brain Imaging.
Nat.Commun., 5, 2014
6F4T
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HUMAN JMJD5 (W414C) IN COMPLEX WITH MN(II), NOG AND RCCD1 (139-143) (COMPLEX-5)
Descriptor:JmjC domain-containing protein 5, RCC1 domain-containing protein 1, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-30
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4O
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HUMAN JMJD5 IN COMPLEX WITH MN(II) AND SUCCINATE.
Descriptor:JmjC domain-containing protein 5, MANGANESE (II) ION, SUCCINIC ACID, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4R
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HUMAN JMJD5 (N308C) IN COMPLEX WITH MN(II), NOG AND RCCD1 (139-143) (COMPLEX-3)
Descriptor:JmjC domain-containing protein 5, RCC1 domain-containing protein 1, MANGANESE (II) ION, ...
Authors:CHOWDHURY, R., Islam, M.S., SCHOFIELD, C.J.
Deposit date:2017-11-30
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
2VBB
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ISOPENICILLIN N SYNTHASE WITH SUBSTRATE ANALOGUE ACOMP (35MINUTES OXYGEN EXPOSURE)
Descriptor:ISOPENICILLIN N SYNTHETASE, N^6^-{(1R)-2-{[(1S,2R)-1-carboxy-2-hydroxy-2-(methylsulfanyl)ethyl]oxy}-1-[(oxidosulfanyl)methyl]-2-oxoethyl}-6-oxo-L-lysine, FE (II) ION, ...
Authors:Ge, W., Clifton, I.J., Adlington, R.M., Baldwin, J.E., Rutledge, P.J.
Deposit date:2007-09-07
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?
J.Am.Chem.Soc., 130, 2008
2Y60
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ISOPENICILLIN N SYNTHASE WITH AC-D-METHIONINE
Descriptor:ISOPENICILLIN N SYNTHASE, N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-methionine, FE (III) ION, ...
Authors:Rutledge, P.J., Clifton, I.J., Ge, W.
Deposit date:2011-01-19
Release date:2012-02-08
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of Isopenicillin N Synthase with Delta((L)-Alpha-Aminoadipoyl)-(L)-Cysteinyl-(D)-Methionine Reveals Thioether Coordination to Iron.
Arch.Biochem.Biophys., 516, 2011
6F4P
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HUMAN JMJD5 IN COMPLEX WITH MN, NOG AND RPS6 (129-144) (COMPLEX-1)
Descriptor:JmjC domain-containing protein 5, 40S ribosomal protein S6, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4S
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HUMAN JMJD5 (N308C) IN COMPLEX WITH MN(II), 2OG AND RCCD1 (139-143) (COMPLEX-4)
Descriptor:JmjC domain-containing protein 5, RCC1 domain-containing protein 1, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-30
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.461 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
2VBP
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ISOPENICILLIN N SYNTHASE WITH SUBSTRATE ANALOGUE L,L,L-ACAB (UNEXPOSED)
Descriptor:ISOPENICILLIN N SYNTHETASE, FE (II) ION, N^6^-[(1R)-2-{[(1S)-1-carboxypropyl]amino}-2-oxo-1-(sulfanylmethyl)ethyl]-6-oxo-L-lysine, ...
Authors:Ge, W., Clifton, I.J., Adlington, R.M., Baldwin, J.E., Rutledge, P.J.
Deposit date:2007-09-14
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallographic Studies on the Binding of Selectively Deuterated Lld- and Lll-Substrate Epimers by Isopenicillin N Synthase.
Biochem.Biophys.Res.Commun., 398, 2010
2VCM
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ISOPENICILLIN N SYNTHASE WITH SUBSTRATE ANALOGUE ASMCOV
Descriptor:ISOPENICILLIN N SYNTHETASE, FE (II) ION, N^6^-[(1R,2S)-1-({[(1R)-1-carboxy-2-methylpropyl]oxy}carbonyl)-2-sulfanylpropyl]-6-oxo-L-lysine, ...
Authors:Ge, W., Clifton, I.J., Adlington, R.M., Baldwin, J.E., Rutledge, P.J.
Deposit date:2007-09-25
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue.
Chembiochem, 10, 2009
5LB6
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) R371H VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBB
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) R396T VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
6F4M
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HUMAN JMJD5 IN ITS APO FORM.
Descriptor:JmjC domain-containing protein 5
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
5LBE
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) G294E VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
2Y6F
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ISOPENICILLIN N SYNTHASE WITH AC-D-S-METHYL-3R-METHYLCYSTEINE
Descriptor:ISOPENICILLIN N SYNTHASE, (2S)-2-AMINO-6-[[(2R)-1-[[(2S)-1-HYDROXY-3-METHYLSULFANYL-1-OXO-BUTAN-2-YL]AMINO]-1-OXO-3-SULFANYL-PROPAN-2-YL]AMINO]-6-OXO-HEXANOIC ACID, FE (III) ION, ...
Authors:Rutledge, P.J., Clifton, I.J., Ge, W.
Deposit date:2011-01-21
Release date:2011-08-31
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Isopenicillin N Synthase Binds Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D-Thia-Allo-Isoleucine Through Both Sulfur Atoms.
Chembiochem, 12, 2011
2VAU
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ISOPENICILLIN N SYNTHASE WITH SUBSTRATE ANALOGUE ACOMP (UNEXPOSED)
Descriptor:ISOPENICILLIN N SYNTHETASE, FE (II) ION, N6^-[(1R)-2-[(1S)-1-CARBOXY-2-(METHYLSULFANYL)ETHOXY]-2-OXO-1-(SULFANYLMETHYL)ETHYL]-6-OXO-L-LYSINE
Authors:Ge, W., Clifton, I.J., Adlington, R.M., Baldwin, J.E., Rutledge, P.J.
Deposit date:2007-09-04
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?
J.Am.Chem.Soc., 130, 2008
5L9R
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HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-10
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBC
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) I280V/R281L/I292V VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.816 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
3ZOI
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ISOPENICILLIN N SYNTHASE WITH AC-O-METHYL-D-THREONINE
Descriptor:ISOPENICILLIN N SYNTHASE, DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-O-METHYL-D-THREONINE, FE (III) ION, ...
Authors:Rutledge, P.J., Clifton, I.J., Ge, W.
Deposit date:2013-02-21
Release date:2013-06-26
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The Crystal Structure of an Isopenicillin N Synthase Complex with an Ethereal Substrate Analogue Reveals Water in the Oxygen Binding Site.
FEBS Lett., 587, 2013
5L9V
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-11
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.829 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBF
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) K293K/G294E VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-16
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8995 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
4NHK
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CRYSTAL STRUCTURE OF TPA1P FROM SACCHAROMYCES CEREVISIAE, TERMINATION AND POLYADENYLATION PROTEIN 1, IN COMPLEX WITH PYRIDINE-2,4-DICARBOXYLIC ACID (2,4-PDCA)
Descriptor:PKHD-type hydroxylase TPA1, MANGANESE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Scotti, J.S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
4NHM
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CRYSTAL STRUCTURE OF TPA1P FROM SACCHAROMYCES CEREVISIAE, TERMINATION AND POLYADENYLATION PROTEIN 1, IN COMPLEX WITH N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:PKHD-type hydroxylase TPA1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, MANGANESE (II) ION, ...
Authors:Scotti, J.S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
5LAT
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) P317R VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
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