Author results

6F4M
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HUMAN JMJD5 IN ITS APO FORM.
Descriptor:JmjC domain-containing protein 5
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4N
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HUMAN JMJD5 IN COMPLEX WITH MN AND 2OG.
Descriptor:JmjC domain-containing protein 5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4O
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HUMAN JMJD5 IN COMPLEX WITH MN(II) AND SUCCINATE.
Descriptor:JmjC domain-containing protein 5, MANGANESE (II) ION, SUCCINIC ACID, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4P
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HUMAN JMJD5 IN COMPLEX WITH MN, NOG AND RPS6 (129-144) (COMPLEX-1)
Descriptor:JmjC domain-containing protein 5, 40S ribosomal protein S6, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4Q
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HUMAN JMJD5 (Q275C) IN COMPLEX WITH MN(II), NOG AND RPS6-A138C (129-144) (COMPLEX-2)
Descriptor:JmjC domain-containing protein 5, 40S ribosomal protein S6, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-29
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4R
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HUMAN JMJD5 (N308C) IN COMPLEX WITH MN(II), NOG AND RCCD1 (139-143) (COMPLEX-3)
Descriptor:JmjC domain-containing protein 5, RCC1 domain-containing protein 1, MANGANESE (II) ION, ...
Authors:CHOWDHURY, R., Islam, M.S., SCHOFIELD, C.J.
Deposit date:2017-11-30
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4S
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HUMAN JMJD5 (N308C) IN COMPLEX WITH MN(II), 2OG AND RCCD1 (139-143) (COMPLEX-4)
Descriptor:JmjC domain-containing protein 5, RCC1 domain-containing protein 1, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-30
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.461 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
6F4T
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HUMAN JMJD5 (W414C) IN COMPLEX WITH MN(II), NOG AND RCCD1 (139-143) (COMPLEX-5)
Descriptor:JmjC domain-containing protein 5, RCC1 domain-containing protein 1, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Islam, M.S., Schofield, C.J.
Deposit date:2017-11-30
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
5NFN
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JMJD7 IN COMPLEX WITH MN AND 2OG IN THE H32 FORM
Descriptor:JmjC domain-containing protein 7, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Chowdhury, R., Markolovic, S., Schofield, C.J.
Deposit date:2017-03-14
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.982 Å)
Cite:(3S)-Lysyl hydroxylation of TRAFAC GTPases is catalyzed by the human Jumonji-C oxygenase JMJD7.
To Be Published
5NFO
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HUMAN JMJD7 IN COMPLEX WITH MN AND 2OG IN THE P21212 FORM
Descriptor:JmjC domain-containing protein 7, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:CHOWDHURY, R., Markolovic, S., SCHOFIELD, C.J.
Deposit date:2017-03-14
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.173 Å)
Cite:(3S)-Lysyl hydroxylation of TRAFAC GTPases is catalyzed by the human Jumonji-C oxygenase JMJD7.
To Be Published
5L9B
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HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-10
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9R
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HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-10
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9V
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-11
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.829 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LA9
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/V314C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-2)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-14
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LAS
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C/R396T) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-3)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-14
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LAT
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) P317R VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LB6
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) R371H VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBB
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) R396T VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBC
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) I280V/R281L/I292V VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.816 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBE
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) G294E VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBF
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) K293K/G294E VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-16
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8995 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5FWE
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JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H4(1-15)R3ME2S PEPTIDE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, SYNTHETIC PEPTIDE, NICKEL (II) ION, ...
Authors:Chowdhury, R., Walport, L.J., Schofield, C.J.
Deposit date:2016-02-15
Release date:2016-04-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Arginine Demethylation is Catalysed by a Subset of Jmjc Histone Lysine Demethylases.
Nat.Commun., 7, 2016
4NHK
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CRYSTAL STRUCTURE OF TPA1P FROM SACCHAROMYCES CEREVISIAE, TERMINATION AND POLYADENYLATION PROTEIN 1, IN COMPLEX WITH PYRIDINE-2,4-DICARBOXYLIC ACID (2,4-PDCA)
Descriptor:PKHD-type hydroxylase TPA1, MANGANESE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Scotti, J.S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
4NHL
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CRYSTAL STRUCTURE OF TPA1P FROM SACCHAROMYCES CEREVISIAE, TERMINATION AND POLYADENYLATION PROTEIN 1, IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:PKHD-type hydroxylase TPA1, MANGANESE (II) ION, N-OXALYLGLYCINE
Authors:Scotti, J.S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
4NHM
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CRYSTAL STRUCTURE OF TPA1P FROM SACCHAROMYCES CEREVISIAE, TERMINATION AND POLYADENYLATION PROTEIN 1, IN COMPLEX WITH N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:PKHD-type hydroxylase TPA1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, MANGANESE (II) ION, ...
Authors:Scotti, J.S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
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