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3B0B
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-S/CENP-X COMPLEX
Descriptor:Centromere protein S, Centromere protein X
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3B0C
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W COMPLEX, CRYSTAL FORM I
Descriptor:Centromere protein T, Centromere protein W, CITRIC ACID
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3B0D
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W COMPLEX, CRYSTAL FORM II
Descriptor:Centromere protein T, Centromere protein W, CITRIC ACID
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3VH5
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W/CENP-S/CENP-X HETEROTETRAMERIC COMPLEX, CRYSTAL FORM I
Descriptor:CENP-S, CENP-X, CENP-T, ...
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-08-23
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold
Cell(Cambridge,Mass.), 148, 2012
3VH6
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W/CENP-S/CENP-X HETEROTETRAMERIC COMPLEX, CRYSTAL FORM II
Descriptor:CENP-S, CENP-X, CENP-T, ...
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-08-23
Release date:2012-03-07
Method:X-RAY DIFFRACTION (3.351 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold
Cell(Cambridge,Mass.), 148, 2012
5KTU
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO PYRAZOLOPIPERIDINE SCAFFOLD
Descriptor:CREB-binding protein, 1-(3-phenylazanyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone, DIMETHYL SULFOXIDE
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5KTW
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD 44 (3-((5-ACETYL-1-(CYCLOPROPYLMETHYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-YL)AMINO)-N-ISOPROPYLBENZAMIDE)
Descriptor:CREB-binding protein, 3-[[1-(cyclopropylmethyl)-5-ethanoyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]amino]-~{N}-propan-2-yl-benzamide, 1,2-ETHANEDIOL
Authors:Murray, J.M., Boenig, G.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.087 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5KTX
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD59 ((S)-1-(3-((2-FLUORO-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)AMINO)-1-(TETRAHYDROFURAN-3-YL)-6,7-DIHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-5(4H)-YL)ETHANONE)
Descriptor:CREB-binding protein, 1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone, 1,2-ETHANEDIOL, ...
Authors:Murray, J.M., Noland, C.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5KU3
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BRD4 BROMODOMAIN IN COMPLEX WITH CPD59 ((S)-1-(3-((2-FLUORO-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)AMINO)-1-(TETRAHYDROFURAN-3-YL)-6,7-DIHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-5(4H)-YL)ETHANONE)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Murray, J.M., Huang, W.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5W0F
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD3 ((S)-1-(3-(6-(1-METHYL-1H-PYRAZOL-4-YL)-3,4-DIHYDROQUINOLIN-1(2H)-YL)-1-(TETRAHYDROFURAN-3-YL)-1,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDIN-5-YL)ETHAN-1-ONE)
Descriptor:CREB-binding protein, 1-{3-[6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one
Authors:Murray, J.M.
Deposit date:2017-05-30
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
5W0I
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD8 (1-(3-(7-(DIFLUOROMETHYL)-6-(1-METHYL-1H-PYRAZOL-4-YL)-3,4-DIHYDROQUINOLIN-1(2H)-YL)-1-(TETRAHYDROFURAN-3-YL)-1,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDIN-5-YL)ETHAN-1-ONE)
Descriptor:CREB-binding protein, 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, DIMETHYL SULFOXIDE, ...
Authors:Murray, J.M.
Deposit date:2017-05-30
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
5W0L
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD10 (1-(3-(7-(DIFLUOROMETHYL)-6-(1-METHYL-1H-PYRAZOL-4-YL)-3,4-DIHYDROQUINOLIN-1(2H)-YL)-1-(TETRAHYDRO-2H-PYRAN-4-YL)-1,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDIN-5-YL)ETHAN-1-ONE)
Descriptor:CREB-binding protein, 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one
Authors:Murray, J.M.
Deposit date:2017-05-31
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.549 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
5W0Q
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD17 (N,2,7-TRIMETHYL-2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZINE-4-CARBOXAMIDE)
Descriptor:CREB-binding protein, SULFATE ION, (2R)-N,2,7-trimethyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide
Authors:Murray, J.M.
Deposit date:2017-05-31
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017