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3U15
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BU of 3u15 by Molmil
Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443
Descriptor: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, Protein Mdm4, SULFATE ION
Authors:Lukacs, C.M, Janson, C.A, Graves, B.J.
Deposit date:2011-09-29
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc.Natl.Acad.Sci.USA, 109, 2012
3VBG
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BU of 3vbg by Molmil
Structure of hDM2 with Dimer Inducing Indolyl Hydantoin RO-2443
Descriptor: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, E3 ubiquitin-protein ligase Mdm2
Authors:Lukacs, C.M, Janson, C.A, Graves, B.J.
Deposit date:2012-01-02
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc.Natl.Acad.Sci.USA, 109, 2012
7L28
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BU of 7l28 by Molmil
Crystal structure of the catalytic domain of human PDE3A bound to Trequinsin
Descriptor: (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one, ACETATE ION, MAGNESIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-12-16
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
7L29
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BU of 7l29 by Molmil
Crystal structure of the catalytic domain of human PDE3A bound to AMP
Descriptor: ACETATE ION, ADENOSINE MONOPHOSPHATE, CALCIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-12-16
Release date:2021-06-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
7L27
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BU of 7l27 by Molmil
Crystal structure of the catalytic domain of human PDE3A
Descriptor: ACETATE ION, CALCIUM ION, MAGNESIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-12-16
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
7KWE
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BU of 7kwe by Molmil
Crystal structure of the catalytic domain of human PDE3A bound to DNMDP
Descriptor: (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one, ACETATE ION, MAGNESIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-11-30
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
4MQ2
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BU of 4mq2 by Molmil
The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor
Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L.
Deposit date:2013-09-15
Release date:2013-12-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4MQ1
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BU of 4mq1 by Molmil
The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor
Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, PENTAETHYLENE GLYCOL, ...
Authors:Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L.
Deposit date:2013-09-15
Release date:2013-12-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013

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