Author results

1D63
  • Download 1d63
  • View 1d63
Molmil generated image of 1d63
CRYSTAL STRUCTURE OF A BERENIL-D(CGCAAATTTGCG) COMPLEX; AN EXAMPLE OF DRUG-DNA RECOGNITION BASED ON SEQUENCE-DEPENDENT STRUCTURAL FEATURES
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), MAGNESIUM ION, BERENIL
Authors:Brown, D.G., Sanderson, M.R., Garman, E., Neidle, S.
Deposit date:1992-03-02
Release date:1993-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features.
J.Mol.Biol., 226, 1992
1RTH
  • Download 1rth
  • View 1rth
Molmil generated image of 1rth
HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-05-03
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1RTI
  • Download 1rti
  • View 1rti
Molmil generated image of 1rti
HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 1-(2-HYDROXYETHYLOXYMETHYL)-6-PHENYL THIOTHYMINE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-05-03
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1VRT
  • Download 1vrt
  • View 1vrt
Molmil generated image of 1vrt
HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, MAGNESIUM ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-04-19
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1VRU
  • Download 1vru
  • View 1vru
Molmil generated image of 1vru
HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2-ACETYL-5-METHYLANILINO)ACETAMIDE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-04-19
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1EM0
  • Download 1em0
  • View 1em0
Molmil generated image of 1em0
COMPLEX OF D(CCTAGG) WITH TETRA-[N-METHYL-PYRIDYL] PORPHYRIN
Descriptor:DNA (5'-D(*(CBR)P*CP*TP*AP*GP*G)-3'), MAGNESIUM ION, TETRA[N-METHYL-PYRIDYL] PORPHYRIN-NICKEL
Authors:Neidle, S., Sanderson, M., Bennett, M., Krah, A., Wien, F., Garman, E., McKenna, R.
Deposit date:2000-03-14
Release date:2000-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling.
Proc.Natl.Acad.Sci.USA, 97, 2000
1HDI
  • Download 1hdi
  • View 1hdi
Molmil generated image of 1hdi
PIG MUSCLE 3-PHOSPHOGLYCERATE KINASE COMPLEXED WITH 3-PG AND MGADP.
Descriptor:PHOSPHOGLYCERATE KINASE, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ...
Authors:Szilagyi, A.N., Ghosh, M., Garman, E., Vas, M.
Deposit date:2000-11-16
Release date:2001-02-26
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A 1.8 A resolution structure of pig muscle 3-phosphoglycerate kinase with bound MgADP and 3-phosphoglycerate in open conformation: new insight into the role of the nucleotide in domain closure.
J. Mol. Biol., 306, 2001
1PPN
  • Download 1ppn
  • View 1ppn
Molmil generated image of 1ppn
STRUCTURE OF MONOCLINIC PAPAIN AT 1.60 ANGSTROMS RESOLUTION
Descriptor:PAPAIN, UNKNOWN LIGAND, METHANOL
Authors:Pickersgill, R.W., Harris, G.W., Garman, E.
Deposit date:1991-10-25
Release date:1994-01-31
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Monoclinic Papain at 1.60 Angstroms Resolution
Acta Crystallogr.,Sect.B, 48, 1992
261D
  • Download 261d
  • View 261d
Molmil generated image of 261d
CRYSTAL STRUCTURE OF THE DNA DECAMER D(CGCAATTGCG) COMPLEXED WITH THE MINOR GROOVE BINDING DRUG NETROPSIN
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*TP*TP*GP*CP*G)-3'), NETROPSIN
Authors:Nunn, C.M., Garman, E., Neidle, S.
Deposit date:1996-11-08
Release date:1997-04-22
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the DNA decamer d(CGCAATTGCG) complexed with the minor groove binding drug netropsin.
Biochemistry, 36, 1997
295D
  • Download 295d
  • View 295d
Molmil generated image of 295d
CRYSTAL AND SOLUTION STRUCTURES OF THE OLIGONUCLEOTIDE D(ATGCGCAT)2: A COMBINED X-RAY AND NMR STUDY
Descriptor:DNA (5'-D(*AP*TP*GP*CP*GP*CP*AP*T)-3')
Authors:Clark, G.R., Brown, D.G., Sanderson, M.R., Chwalinski, T., Neidle, S., Veal, J.M., Jones, R.L., Wilson, W.D., Zon, G., Garman, E., Stuart, D.I.
Deposit date:1991-05-28
Release date:1996-12-04
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.
Nucleic Acids Res., 18, 1990
2DBE
  • Download 2dbe
  • View 2dbe
Molmil generated image of 2dbe
CRYSTAL STRUCTURE OF A BERENIL-DODECANUCLEOTIDE COMPLEX: THE ROLE OF WATER IN SEQUENCE-SPECIFIC LIGAND BINDING
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), BERENIL
Authors:Brown, D.G., Sanderson, M.R., Skelly, J.V., Jenkins, T.C., Brown, T., Garman, E., Stuart, D.I., Neidle, S.
Deposit date:1990-03-19
Release date:1991-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding.
EMBO J., 9, 1990
2VHL
  • Download 2vhl
  • View 2vhl
Molmil generated image of 2vhl
THE THREE-DIMENSIONAL STRUCTURE OF THE N-ACETYLGLUCOSAMINE-6- PHOSPHATE DEACETYLASE FROM BACILLUS SUBTILIS
Descriptor:N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE, GLUCOSAMINE 6-PHOSPHATE, TRIETHYLENE GLYCOL, ...
Authors:Vincent, F., Yates, D., Garman, E., Davies, G.J.
Deposit date:2007-11-22
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Three-Dimensional Structure of the N-Acetylglucosamine-6-Phosphate Deacetylase from Bacillus Subtilis
J.Biol.Chem., 279, 2004
1KIT
  • Download 1kit
  • View 1kit
Molmil generated image of 1kit
VIBRIO CHOLERAE NEURAMINIDASE
Descriptor:SIALIDASE, CALCIUM ION
Authors:Taylor, G.L., Crennell, S.J., Garman, E.F., Vimr, E.R., Laver, W.G.
Deposit date:1996-06-21
Release date:1997-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Vibrio cholerae neuraminidase reveals dual lectin-like domains in addition to the catalytic domain.
Structure, 2, 1994
1DIL
  • Download 1dil
  • View 1dil
Molmil generated image of 1dil
SIALIDASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH APANA AND EPANA INHIBITORS
Descriptor:SIALIDASE, (4-ACETAMIDO-2,4-DIDEOXY-D-GLYCERO-ALPHA-D-GALACTO-1-OCTOPYRANOSYL)PHOSPHONIC ACID, 4-ACETAMIDO-2,4-DIDEXOY-D-GLYCERO-BETA-D-GALACTO-OCTOPYRANOSYLPHOSPHONIC ACID (AN AXIAL PHOSPHONATE), ...
Authors:Garman, E.F., Crennell, S.C., Vimr, E.R., Laver, W.G., Taylor, G.L.
Deposit date:1996-04-23
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
J.Mol.Biol., 259, 1996
1DIM
  • Download 1dim
  • View 1dim
Molmil generated image of 1dim
SIALIDASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH EPANA INHIBITOR
Descriptor:SIALIDASE, POTASSIUM ION, (4-ACETAMIDO-2,4-DIDEOXY-D-GLYCERO-ALPHA-D-GALACTO-1-OCTOPYRANOSYL)PHOSPHONIC ACID
Authors:Garman, E.F., Crennell, S.C., Vimr, E.R., Laver, W.G., Taylor, G.L.
Deposit date:1996-04-23
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
J.Mol.Biol., 259, 1996
1C0T
  • Download 1c0t
  • View 1c0t
Molmil generated image of 1c0t
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), (R)-(+)9B-(3-METHYL)PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-5(9BH)-ONE
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1C0U
  • Download 1c0u
  • View 1c0u
Molmil generated image of 1c0u
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), (R)-(+) 5(9BH)-OXO-9B-PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-3-CARBOXYLIC ACID METHYL ESTER
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1C1B
  • Download 1c1b
  • View 1c1b
Molmil generated image of 1c1b
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), 6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL
Authors:Hopkins, A.L., Ren, J., Tanaka, H., Baba, B., Okamato, M., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-21
Release date:2000-07-21
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
J.Med.Chem., 42, 1999
1C1C
  • Download 1c1c
  • View 1c1c
Molmil generated image of 1c1c
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), 6-(cyclohexylsulfanyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione
Authors:Hopkins, A.L., Ren, J., Tanaka, H., Baba, M., Okamato, M., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-21
Release date:2000-07-21
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
J.Med.Chem., 42, 1999
1FK9
  • Download 1fk9
  • View 1fk9
Molmil generated image of 1fk9
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor:HIV-1 RT, A-CHAIN, B-CHAIN, ...
Authors:Ren, J., Milton, J., Weaver, K.L., Short, S.A., Stuart, D.I., Stammers, D.K.
Deposit date:2000-08-09
Release date:2000-11-03
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
STRUCTURE FOLD.DES., 8, 2000
1FKO
  • Download 1fko
  • View 1fko
Molmil generated image of 1fko
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor:HIV-1 RT, A-CHAIN, B-CHAIN, ...
Authors:Ren, J., Milton, J., Weaver, K.L., Short, S.A., Stuart, D.I., Stammers, D.K.
Deposit date:2000-08-10
Release date:2000-11-03
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure Fold.Des., 8, 2000
1FKP
  • Download 1fkp
  • View 1fkp
Molmil generated image of 1fkp
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 RT, A-CHAIN, B-CHAIN, ...
Authors:Ren, J., Milton, J., Weaver, K.L., Short, S.A., Stuart, D.I., Stammers, D.K.
Deposit date:2000-08-10
Release date:2000-11-03
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure Fold.Des., 8, 2000
1JKH
  • Download 1jkh
  • View 1jkh
Molmil generated image of 1jkh
CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor:HIV-1 RT, A-CHAIN, B-CHAIN, ...
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-12
Release date:2001-10-03
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLA
  • Download 1jla
  • View 1jla
Molmil generated image of 1jla
CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
Descriptor:HIV-1 RT A-chain, HIV-1 RT B-chain, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLB
  • Download 1jlb
  • View 1jlb
Molmil generated image of 1jlb
CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 RT A-chain, HIV-1 RT B-chain, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
<123>