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1KKU
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BU of 1kku by Molmil
Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase
Descriptor: NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE
Authors:Garavaglia, S, D'Angelo, I, Emanuelli, M, Carnevali, F, Pierella, F, Magni, G, Rizzi, M.
Deposit date:2001-12-10
Release date:2002-06-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis.
J.Biol.Chem., 277, 2002
2WM1
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BU of 2wm1 by Molmil
The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis
Descriptor: 1,3-DIHYDROXYACETONEPHOSPHATE, 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE, GLYCEROL, ...
Authors:Garavaglia, S, Perozzi, S, Galeazzi, L, Raffaelli, N, Rizzi, M.
Deposit date:2009-06-29
Release date:2009-11-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The Crystal Structure of Human Alpha-Amino-Beta-Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3-Dihydroxyacetonephosphate Suggests a Regulatory Link between Nad Synthesis and Glycolysis
FEBS J., 276, 2009
3ZU0
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BU of 3zu0 by Molmil
Structure of Haemophilus influenzae NAD nucleotidase (NadN)
Descriptor: NAD NUCLEOTIDASE, PHOSPHATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M.
Deposit date:2011-07-13
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012
3ZTV
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BU of 3ztv by Molmil
Structure of Haemophilus influenzae NAD nucleotidase (NadN)
Descriptor: ADENOSINE, GLYCEROL, NAD NUCLEOTIDASE, ...
Authors:Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M.
Deposit date:2011-07-12
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012
1U0R
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BU of 1u0r by Molmil
Crystal structure of Mycobacterium tuberculosis NAD kinase
Descriptor: Inorganic polyphosphate/ATP-NAD kinase
Authors:Garavaglia, S, Raffaelli, N, Finaurini, L, Magni, G, Rizzi, M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-07-14
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis
J.Biol.Chem., 279, 2004
1U0T
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BU of 1u0t by Molmil
Crystal structure of Mycobacterium tuberculosis NAD kinase
Descriptor: Inorganic polyphosphate/ATP-NAD kinase
Authors:Garavaglia, S, Raffaelli, N, Finaurini, L, Magni, G, Rizzi, M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-07-14
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis
J.Biol.Chem., 279, 2004
6TGW
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BU of 6tgw by Molmil
Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor
Descriptor: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate
Authors:Garavaglia, S, Rizzi, M.
Deposit date:2019-11-18
Release date:2021-06-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Commun Biol, 4, 2021
1V10
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BU of 1v10 by Molmil
Structure of Rigidoporus lignosus laccase from hemihedrally twinned crystals
Descriptor: COPPER (II) ION, LACCASE
Authors:Rizzi, M, Garavaglia, S, Palmieri, F, Cambria, A.
Deposit date:2004-04-02
Release date:2004-09-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of Rigidoporus Lignosus Laccase Containing a Full Complement of Copper Ions, Reveals an Asymmetrical Arrangement for the T3 Copper Pair
J.Mol.Biol., 342, 2004
4YUB
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BU of 4yub by Molmil
Crystal structure of human Nicotinic Acid Phosphoribosyltransferase
Descriptor: Nicotinate phosphoribosyltransferase
Authors:Garavaglia, S, Rizzi, M, Marletta, A.S.
Deposit date:2015-03-18
Release date:2015-05-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human nicotinic acid phosphoribosyltransferase.
Febs Open Bio, 5, 2015
5MP7
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BU of 5mp7 by Molmil
Crystal structure of phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis
Descriptor: ACETATE ION, Ribose-phosphate pyrophosphokinase
Authors:Donini, S, Garavaglia, S, Ferraris, D.M, Miggiano, R, Mori, S, Shibayama, K, Rizzi, M.
Deposit date:2016-12-16
Release date:2017-04-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis.
PLoS ONE, 12, 2017
6S6W
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BU of 6s6w by Molmil
Crystal Structure of human ALDH1A3 in complex with 2,6-diphenylimidazo[1,2-a]pyridine (compound GA11) and NAD+
Descriptor: 2,6-diphenylimidazo[1,2-a]pyridine, Aldehyde dehydrogenase family 1 member A3, GLYCEROL, ...
Authors:Gelardi, E.L.M, Quattrini, L, LaMotta, C, Ferraris, D.M, Garavaglia, S.
Deposit date:2019-07-03
Release date:2020-04-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.
J.Med.Chem., 63, 2020
5FHZ
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BU of 5fhz by Molmil
Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid
Descriptor: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, RETINOIC ACID
Authors:Moretti, A, Rizzi, M, Garavaglia, S.
Deposit date:2015-12-22
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid.
Sci Rep, 6, 2016
7A6Q
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BU of 7a6q by Molmil
Crystal structure of human aldehyde dehydrogenase 1A3 in complex with selective NR6 inhibitor compound
Descriptor: (3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium, 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile, Aldehyde dehydrogenase family 1 member A3, ...
Authors:Gelardi, E.L.M, Garavaglia, S.
Deposit date:2020-08-26
Release date:2021-02-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro.
Cancers (Basel), 13, 2021
2VGZ
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BU of 2vgz by Molmil
CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE II
Descriptor: IODIDE ION, KYNURENINE/ALPHA-AMINOADIPATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Rossi, F, Garavaglia, S, Montalbano, V, Walsh, M.A, Rizzi, M.
Deposit date:2007-11-16
Release date:2007-12-04
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Kynurenine Aminotransferase II, a Drug Target for the Treatment of Schizophrenia.
J.Biol.Chem., 283, 2008
6TE5
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BU of 6te5 by Molmil
Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with LQ43 inhibitor compound
Descriptor: 6-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine, Aldehyde dehydrogenase family 1 member A3, GLYCEROL, ...
Authors:Gelardi, E.L.M, Garavaglia, S.
Deposit date:2019-11-11
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Imidazo[1,2- a ]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.
J.Med.Chem., 63, 2020
4WXD
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BU of 4wxd by Molmil
Crystal structure of Mycobacterium tuberculosis OGT-R37K
Descriptor: GLYCEROL, Methylated-DNA--protein-cysteine methyltransferase
Authors:Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M.
Deposit date:2014-11-13
Release date:2015-11-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J., 473, 2016
4WX9
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BU of 4wx9 by Molmil
Crystal structure of Mycobacterium tuberculosis OGT in complex with DNA
Descriptor: DNA (5'-D(*GP*CP*CP*AP*TP*GP*(E1X)P*CP*TP*AP*GP*TP*A)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3'), GLYCEROL, ...
Authors:Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M.
Deposit date:2014-11-13
Release date:2015-11-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J., 473, 2016
4WXC
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BU of 4wxc by Molmil
Crystal structure of Mycobacterium tuberculosis OGT-Y139F
Descriptor: 1,2-ETHANEDIOL, Methylated-DNA--protein-cysteine methyltransferase
Authors:Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M.
Deposit date:2014-11-13
Release date:2015-11-04
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J., 473, 2016
2XH1
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BU of 2xh1 by Molmil
Crystal structure of human KAT II-inhibitor complex
Descriptor: (3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE, GLYCEROL, IODIDE ION, ...
Authors:Rossi, F, Casazza, V, Garavaglia, S, Sathyasaikumar, K.V, Schwarcz, R, Kojima, S.I, Okuwaki, K, Ono, S.I, Kajii, Y, Rizzi, M.
Deposit date:2010-06-08
Release date:2010-07-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure-Based Selective Targeting of the Pyridoxal 5'-Phsosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement
J.Med.Chem., 53, 2010
6TRY
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BU of 6try by Molmil
Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with MF13 inhibitor compound
Descriptor: 8-(4-chlorophenyl)-2-phenyl-imidazo[1,2-a]pyridine, Aldehyde dehydrogenase family 1 member A3, GLYCEROL, ...
Authors:Gelardi, E.L.M, Garavaglia, S.
Deposit date:2019-12-19
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2- a ]pyridines against the 1A Family.
Acs Med.Chem.Lett., 11, 2020
2CH2
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BU of 2ch2 by Molmil
Structure of the Anopheles gambiae 3-hydroxykynurenine transaminase in complex with inhibitor
Descriptor: 3-HYDROXYKYNURENINE TRANSAMINASE, 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID, PYRIDOXAL-5'-PHOSPHATE
Authors:Rossi, F, Garavaglia, S, Giovenzana, G.B, Arca, B, Li, J, Rizzi, M.
Deposit date:2006-03-10
Release date:2006-03-28
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Anopheles Gambiae 3-Hydroxykynurenine Transaminase
Proc.Natl.Acad.Sci.USA, 103, 2006
2CH1
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Structure of Anopheles gambiae 3-hydroxykynurenine transaminase
Descriptor: 3-HYDROXYKYNURENINE TRANSAMINASE, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE
Authors:Rossi, F, Garavaglia, S, Giovenzana, G.B, Arca, B, Li, J, Rizzi, M.
Deposit date:2006-03-10
Release date:2006-03-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Anopheles Gambiae 3-Hydroxykynurenine Transaminase
Proc.Natl.Acad.Sci.USA, 103, 2006
4BHC
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BU of 4bhc by Molmil
CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT
Descriptor: METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
Authors:Miggiano, R, Casazza, V, Garavaglia, S, Ciaramella, M, Perugino, G, Rizzi, M, Rossi, F.
Deposit date:2013-04-02
Release date:2013-04-17
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Biochemical and Structural Studies on the M. Tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants.
J.Bacteriol., 195, 2013
4BHB
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BU of 4bhb by Molmil
Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE
Descriptor: GLYCEROL, METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
Authors:Miggiano, R, Casazza, V, Garavaglia, S, Ciaramella, M, Perugino, G, Rizzii, M, Rossi, F.
Deposit date:2013-04-02
Release date:2013-04-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biochemical and Structural Studies of the Mycobacterium Tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants.
J.Bacteriol., 195, 2013

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