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6HJN
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STRUCTURE OF INFLUENZA HEMAGGLUTININ ECTODOMAIN (A/DUCK/ALBERTA/35/76)
分子名称:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Benton, D.J., Rosenthal, P.B.
登録日2018-09-04
公開日2018-09-26
最終更新日2018-10-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Influenza hemagglutinin membrane anchor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HJP
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STRUCTURE OF INFLUENZA HEMAGGLUTININ ECTODOMAIN (A/DUCK/ALBERTA/35/76) IN COMPLEX WITH FISW84 FAB FRAGMENT
分子名称:Hemagglutinin, Heavy chain of FISW84 Fab Fragment, Light chain of FISW84 Fab Fragment, ...
著者Benton, D.J., Rosenthal, P.B.
登録日2018-09-04
公開日2018-09-26
最終更新日2018-10-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Influenza hemagglutinin membrane anchor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HJQ
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STRUCTURE OF FULL-LENGTH INFLUENZA HEMAGGLUTININ (A/DUCK/ALBERTA/35/76) IN COMPLEX WITH FISW84 FAB FRAGMENT
分子名称:Hemagglutinin, Heavy chain of FISW84 Fab, Light chain of FISW84 Fab, ...
著者Benton, D.J., Rosenthal, P.B.
登録日2018-09-04
公開日2018-09-26
最終更新日2018-10-24
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Influenza hemagglutinin membrane anchor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HJR
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STRUCTURE OF FULL-LENGTH INFLUENZA HEMAGGLUTININ WITH TILTED TRANSMEMBRANE (A/DUCK/ALBERTA/35/76[H1N1])
分子名称:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Benton, D.J., Rosenthal, P.B.
登録日2018-09-04
公開日2018-09-26
最終更新日2018-10-10
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Influenza hemagglutinin membrane anchor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HKG
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STRUCTURE OF FISW84 FAB FRAGMENT
分子名称:FISW84 Fab Fragment Heavy Chain, FISW84 Fab Fragment Light Chain, SULFATE ION
著者Benton, D.J., Rosenthal, P.B.
登録日2018-09-06
公開日2018-09-26
最終更新日2018-10-10
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Influenza hemagglutinin membrane anchor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OV3
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STRUCTURE OF THE RBBP5 BETA-PROPELLER DOMAIN
分子名称:Retinoblastoma-binding protein 5, TRIETHYLENE GLYCOL, TETRAETHYLENE GLYCOL
著者Mittal, A., Zhang, Y., Gamblin, S.J., Wilson, J.R.
登録日2017-08-27
公開日2018-03-28
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The structure of the RbBP5 beta-propeller domain reveals a surface with potential nucleic acid binding sites.
Nucleic Acids Res., 46, 2018
5ISO
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STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Xiao, B., Hubbard, J.A., Gamblin, S.J.
登録日2016-03-15
公開日2017-03-29
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
To Be Published
5LS6
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STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH INHIBITOR
分子名称:Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
著者Zhang, Y., Justin, N., Chen, S., Wilson, J., Gamblin, S.
登録日2016-08-22
公開日2017-02-22
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (3.47 Å)
主引用文献Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
5M5G
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CRYSTAL STRUCTURE OF THE CHAETOMIUM THERMOPHILUM POLYCOMB REPRESSIVE COMPLEX 2 (PRC2)
分子名称:putative polycomb protein EED, Putative uncharacterized protein, HISTONE H3 11-Mer peptide, ...
著者Zhang, Y., Justin, N., Wilson, J., Gamblin, S.
登録日2016-10-21
公開日2017-01-11
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
5JW3
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STRUCTURE OF MEDI8852 FAB FRAGMENT IN COMPLEX WITH H7 HA
分子名称:Hemagglutinin, MEDI8852 heavy chain, MEDI8852 light chain, ...
著者Collins, P.J., Neu, U., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J.
登録日2016-05-11
公開日2016-08-03
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (3.75 Å)
主引用文献Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.
Cell, 166, 2016
5JW4
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STRUCTURE OF MEDI8852 FAB FRAGMENT IN COMPLEX WITH H5 HA
分子名称:Hemagglutinin, MEDI8852 heavy chain, MEDI8852 light chain, ...
著者Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J.
登録日2016-05-11
公開日2016-08-03
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.
Cell, 166, 2016
5JW5
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STRUCTURE OF MEDI8852 FAB FRAGMENT
分子名称:MEDI8852 Heavy chain, MEDI8852 Light chain, PHOSPHATE ION
著者Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J.
登録日2016-05-11
公開日2016-08-03
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.
Cell, 166, 2016
5HYN
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STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH ONCOGENIC HISTONE H3K27M PEPTIDE
分子名称:Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
著者Zhang, Y., Justin, N., Wilson, J.R., Gamblin, S.J.
登録日2016-02-01
公開日2016-05-11
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Nat Commun, 7, 2016
5IQP
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14-3-3 PROTEIN TAU ISOFORM
分子名称:14-3-3 protein theta, SULFATE ION
著者Xiao, B., Smerdon, S.J., Gamblin, S.J.
登録日2016-03-11
公開日2016-03-23
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
4Z4P
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STRUCTURE OF THE MLL4 SET DOMAIN
分子名称:Histone-lysine N-methyltransferase 2D, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Zhang, Z., Mittal, A., Reid, J., Reich, S., Gamblin, S.J., Wilson, J.R.
登録日2015-04-02
公開日2015-09-09
最終更新日2015-10-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Evolving Catalytic Properties of the MLL Family SET Domain.
Structure, 23, 2015
5A3I
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CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN FLD194 FAB AND TRANSMISSIBLE MUTANT H5 HAEMAGGLUTININ
分子名称:HEMAGGLUTININ, ANTI-HAEMAGGLUTININ HA1 FAB HEAVY CHAIN, ANTI-HAEMAGGLUTININ HA1 FAB LIGHT CHAIN, ...
著者Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S.R., Lin, Y.P., Walker, P.A., Collins, P.J., Monne, I., Suguitan Jr, A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J.J.
登録日2015-06-01
公開日2015-07-22
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structures of Complexes Formed by H5 Influenza Hemagglutinin with a Potent Broadly Neutralizing Human Monoclonal Antibody.
Proc.Natl.Acad.Sci.USA, 112, 2015
5AJM
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H5 (VN1194) ASN186LYS MUTANT HAEMAGGLUTININ IN COMPLEX WITH AVIAN RECEPTOR ANALOGUE 3'SLN
分子名称:HAEMAGGLUTININ HA1, HAEMAGGLUTININ HA2, N-ACETYL-D-GLUCOSAMINE, ...
著者Xiong, X., Xiao, H., Martin, S.R., Coombs, P.J., Liu, J., Collins, P.J., Vachieri, S.G., Walker, P.A., Lin, Y.P., McCauley, J.W., Gamblin, S.J., Skehel, J.J.
登録日2015-02-25
公開日2015-03-25
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Enhanced Human Receptor Binding by H5 Haemagglutinins.
Virology, 456, 2014
4X3E
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CRYSTAL STRUCTURE OF EED IN COMPLEX WITH A TRIMETHYLATED JARID2 PEPTIDE
分子名称:Polycomb protein EED, ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER
著者Justin, N., Gamblin, S.J., Margueron, R.
登録日2014-11-28
公開日2015-01-21
最終更新日2015-03-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Mol.Cell, 57, 2015
4UNW
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STRUCTURE OF THE A_EQUINE_NEWMARKET_2_93 H3 HAEMAGGLUTININ
分子名称:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
著者Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
登録日2014-05-31
公開日2014-07-23
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UNX
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STRUCTURE OF THE A_EQUINE_NEWMARKET_2_93 H3 HAEMAGGLUTININ IN COMPLEX WITH 3SLN
分子名称:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
著者Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
登録日2014-05-31
公開日2014-07-23
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UNY
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STRUCTURE OF THE A_EQUINE_NEWMARKET_2_93 H3 HAEMAGGLUTININ IN COMPLEX WITH 6SO4-3SLN
分子名称:HAY SUBUNIT OF HAEMAGGLUTININ, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
著者Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
登録日2014-05-31
公開日2014-07-23
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UNZ
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STRUCTURE OF THE A_EQUINE_NEWMARKET_2_93 H3 HAEMAGGLUTININ IN COMPLEX WITH 6SO4-SIALYL LEWIS X
分子名称:HAY SUBUNIT OF HAEMAGGLUTININ, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
著者Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
登録日2014-05-31
公開日2014-07-23
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO0
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STRUCTURE OF THE A_EQUINE_RICHMOND_07 H3 HAEMAGGLUTININ
分子名称:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
登録日2014-05-31
公開日2014-07-23
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO1
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STRUCTURE OF THE A_EQUINE_RICHMOND_07 H3 HAEMAGGLUTININ IN COMPLEX WITH 3SLN
分子名称:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
登録日2014-05-31
公開日2014-07-23
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO2
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STRUCTURE OF THE A_EQUINE_RICHMOND_07 H3 HAEMAGGLUTININ IN COMPLEX WITH SIALYL LEWIS X
分子名称:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
著者Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
登録日2014-05-31
公開日2014-07-23
最終更新日2014-11-19
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014