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1BMA
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BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE
Descriptor:Chymotrypsin-like elastase family member 1, CALCIUM ION, SULFATE ION, ...
Authors:Peisach, E., Casebier, D., Gallion, S.L., Furth, P., Petsko, G.A., Hogan Jr., J.C., Ringe, D.
Deposit date:1995-05-01
Release date:1995-12-07
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interaction of a peptidomimetic aminimide inhibitor with elastase.
Science, 269, 1995
1B0E
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CRYSTAL STRUCTURE OF PORCINE PANCREATIC ELASTASE WITH MDL 101,146
Descriptor:PROTEIN (ELASTASE), CALCIUM ION, 1-{3-METHYL-2-[4-(MORPHOLINE-4-CARBONYL)-BENZOYLAMINO]-BUTYRYL}-PYRROLIDINE-2-CARBOXYLIC ACID (3,3,4,4,4-PENTAFLUORO-1-ISOPROPYL-2-OXO-BUTYL)-AMIDE
Authors:Schreuder, H.A., Metz, W.A., Peet, N.P., Pelton, J.T., Tardif, C.
Deposit date:1998-11-09
Release date:1998-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
J.Med.Chem., 41, 1998
1B0F
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CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE WITH MDL 101, 146
Descriptor:PROTEIN (ELASTASE), N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Schreuder, H.A., Metz, W.A., Peet, N.P., Pelton, J.T., Tardif, C.
Deposit date:1998-11-09
Release date:1998-11-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
J.Med.Chem., 41, 1998
3AID
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A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE
Descriptor:HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, BENZOYLAMINO-BENZYL-METHYL-[2-HYDROXY-3-[1-METHYL-ETHYL-OXY-N-FORMAMIDYL]-4-PHENYL-BUTYL]-AMMONIUM
Authors:Rutenber, E.E., Stroud, R.M.
Deposit date:1997-05-15
Release date:1997-09-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.
Bioorg.Med.Chem., 4, 1996
3OCS
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CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH INHIBITOR CGI1746
Descriptor:Tyrosine-protein kinase BTK, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Davies, D.R., Gallion, S.L., Staker, B.L.
Deposit date:2010-08-10
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel, specific Btk inhibitor antagonizes BCR and Fc[gamma]R signaling and suppresses inflammatory arthritis
To be Published
3P08
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CRYSTAL STRUCTURE OF THE HUMAN BTK KINASE DOMAIN
Descriptor:Tyrosine-protein kinase BTK
Authors:Yu, C.L., Hymowitz, S.G.
Deposit date:2010-09-27
Release date:2010-11-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A novel, specific BTK inhibitor antagonizes BCR and FcgR signaling and suppresses inflammatory arthritis
To be Published