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4P2T
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CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) PROTEASE IN COMPLEX WITH A DIMER DISRUPTOR
Descriptor:KSHV Protease, 6-(cyclohexylmethyl)-N-[4-(methylsulfonylcarbamoyl)-2-(phenylmethyl)phenyl]pyridine-2-carboxamide, DIMETHYL SULFOXIDE
Authors:Gable, J.E.
Deposit date:2014-03-04
Release date:2014-07-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Broad-spectrum allosteric inhibition of herpesvirus proteases.
Biochemistry, 53, 2014
4P3H
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CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) PROTEASE IN COMPLEX WITH DIMER DISRUPTOR
Descriptor:KSHV protease, N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide, GLYCEROL, ...
Authors:Gable, J.E.
Deposit date:2014-03-07
Release date:2014-07-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Broad-spectrum allosteric inhibition of herpesvirus proteases.
Biochemistry, 53, 2014
3NJQ
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CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS PROTEASE IN COMPLEX WITH DIMER DISRUPTOR
Descriptor:ORF 17, ACETATE ION, 3-benzyl-4-({[6-(cyclohexylmethyl)pyridin-2-yl]carbonyl}amino)benzoic acid, ...
Authors:Baharuddin, A.
Deposit date:2010-06-17
Release date:2011-08-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzyme inhibition by allosteric capture of an inactive conformation.
J.Mol.Biol., 411, 2011
5V5D
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ROOM TEMPERATURE (280K) CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS PROTEASE IN COMPLEX WITH ALLOSTERIC INHIBITOR (COMPOUND 250)
Descriptor:ORF 17, 4-{[6-(cyclohexylmethyl)pyridine-2-carbonyl]amino}-3-(phenylamino)benzoic acid
Authors:Thompson, M.C., Acker, T.M., Fraser, J.S., Craik, C.S.
Deposit date:2017-03-14
Release date:2017-04-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.
J. Am. Chem. Soc., 139, 2017
5V5E
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ROOM TEMPERATURE (280K) CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS PROTEASE IN COMPLEX WITH ALLOSTERIC INHIBITOR (COMPOUND 733)
Descriptor:ORF 17, 4-{[6-(cyclohexylmethyl)pyridine-2-carbonyl]amino}-3-{[3-(trifluoromethoxy)phenyl]amino}benzoic acid
Authors:Thompson, M.C., Acker, T.M., Fraser, J.S., Craik, C.S.
Deposit date:2017-03-14
Release date:2017-04-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.
J. Am. Chem. Soc., 139, 2017