Author results

1P6X
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CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH THY AND SO4
Descriptor:Thymidine kinase, SULFATE ION, THYMIDINE
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P72
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CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH THY AND ADP
Descriptor:Thymidine kinase, SULFATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P73
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CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH TP4A
Descriptor:Thymidine kinase, SULFATE ION, P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P75
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CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH TP5A
Descriptor:Thymidine kinase, SULFATE ION, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P7C
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CRYSTAL STRUCTURE OF HSV1-TK COMPLEXED WITH TP5A
Descriptor:Thymidine kinase, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, ...
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-05-01
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
6DI3
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CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH FRAGMENT LIGAND
Descriptor:Tyrosine-protein kinase BTK, 6-[(3S)-3-(acryloylamino)pyrrolidin-1-yl]-2-(4-phenoxyphenoxy)pyridine-3-carboxamide
Authors:GARDBERG, A.
Deposit date:2018-05-22
Release date:2018-09-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Bioorg. Med. Chem. Lett., 28, 2018
6DI5
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CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT INHIBITOR
Descriptor:Tyrosine-protein kinase BTK, 2-(4-phenoxyphenoxy)-6-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyridine-3-carboxamide, DIMETHYL SULFOXIDE
Authors:Gardberg, A.
Deposit date:2018-05-22
Release date:2018-09-05
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Bioorg. Med. Chem. Lett., 28, 2018
6DI9
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CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT INHIBITOR
Descriptor:Tyrosine-protein kinase BTK, 6-[(3S)-3-(acryloylamino)pyrrolidin-1-yl]-2-{[4-(tert-butylcarbamoyl)phenyl]amino}pyridine-3-carboxamide, DIMETHYL SULFOXIDE
Authors:GARDBERG, A.
Deposit date:2018-05-23
Release date:2018-09-05
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Bioorg. Med. Chem. Lett., 28, 2018
3VFI
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CRYSTAL STRUCTURE OF A METAGENOMIC THIOREDOXIN
Descriptor:thioredoxin
Authors:Craig, T.K., Gardberg, A., Lorimer, D.D., Burgin Jr., A.B., Segall, A., Rohwer, F.
Deposit date:2012-01-09
Release date:2013-01-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of a Metagenomic Thioredoxin
To be Published
3MEQ
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CRYSTAL STRUCTURE OF ALCOHOL DEHYDROGENASE FROM BRUCELLA MELITENSIS
Descriptor:Alcohol dehydrogenase, zinc-containing, ZINC ION, ...
Authors:Arakaki, T.L., Staker, B.L., Gardberg, A., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of alcohol dehydrogenase from Brucella melitensis
To be Published
3EYS
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PFA1 FAB FRAGMENT COMPLEXED WITH PYRO-GLU3-A-BETA (3-8)
Descriptor:If kappa light chain, PFA1 Fab Heavy Chain, pyro-Glu3-A-Beta (3-8) peptide, ...
Authors:Gardberg, A.S., Dealwis, C.G.
Deposit date:2008-10-21
Release date:2009-05-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of Abeta-related peptide--monoclonal antibody complexes.
Biochemistry, 48, 2009
3EYU
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PFA1 FAB FRAGMENT COMPLEXED WITH ROR2(518-525)
Descriptor:If kappa light chain, PFA1 Fab Heavy Chain, ROR2(518-525) peptide
Authors:Gardberg, A.S., Dealwis, C.G.
Deposit date:2008-10-21
Release date:2009-05-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structures of Abeta-related peptide--monoclonal antibody complexes.
Biochemistry, 48, 2009
3M1X
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CRYSTAL STRUCTURE OF A PUTATIVE ENDORIBONUCLEASE L-PSP FROM ENTAMOEBA HISTOLYTICA, RHOMOBOHEDRAL FORM
Descriptor:putative Endoribonuclease L-PSP, CITRATE ANION, CHLORIDE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-03-05
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of a putative endoribonuclease L-PSP from Entamoeba histolytica, rhomobohedral form
To be Published
3M4S
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CRYSTAL STRUCTURE OF A PUTATIVE ENDORIBONUCLEASE L-PSP FROM ENTAMOEBA HISTOLYTICA, ORTHORHOMBIC FORM
Descriptor:putative Endoribonuclease L-PSP, CHLORIDE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-03-11
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a putative endoribonuclease L-PSP from Entamoeba histolytica, orthorhombic form
To be Published
3MBD
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CRYSTAL STRUCTURE OF FRUCTOSE BISPHOSPHATE ALDOLASE FROM ENCEPHALITOZOON CUNICULI, BOUND TO PHOSPHATE
Descriptor:Fructose-bisphosphate aldolase, PHOSPHATE ION, CHLORIDE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-03-25
Release date:2010-04-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi.
Acta Crystallogr.,Sect.F, 67, 2011
3MBF
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CRYSTAL STRUCTURE OF FRUCTOSE BISPHOSPHATE ALDOLASE FROM ENCEPHALITOZOON CUNICULI, BOUND TO FRUCTOSE 1,6-BISPHOSPHATE
Descriptor:Fructose-bisphosphate aldolase, 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-03-25
Release date:2010-04-07
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi.
Acta Crystallogr.,Sect.F, 67, 2011
3MMT
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CRYSTAL STRUCTURE OF FRUCTOSE BISPHOSPHATE ALDOLASE FROM BARTONELLA HENSELAE, BOUND TO FRUCTOSE BISPHOSPHATE
Descriptor:Fructose-bisphosphate aldolase, 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-04-20
Release date:2010-05-19
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1,6-bisphosphate.
Acta Crystallogr.,Sect.F, 67, 2011
3MPD
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CRYSTAL STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE FROM ENCEPHALITOZOON CUNICULI, CUBIC FORM, APO
Descriptor:Nucleoside diphosphate kinase, 1,2-ETHANEDIOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-04-26
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal structure of nucleoside diphosphate kinase from encephalitozoon cuniculi
To be published
3MQW
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CRYSTAL STRUCTURE OF A PUTATIVE ENDORIBONUCLEASE L-PSP FROM ENTAMOEBA HISTOLYTICA WITH HIGHER SOLVENT CONTENT AND AN ORDERED N-TERMINAL TAG
Descriptor:putative Endoribonuclease L-PSP, CITRATE ANION, GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-04-28
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a putative endoribonuclease L-PSP from Entamoeba histolytica
To be published
3RMI
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CRYSTAL STRUCTURE OF CHORISMATE MUTASE FROM BARTONELLA HENSELAE STR. HOUSTON-1 IN COMPLEX WITH MALATE
Descriptor:Chorismate mutase protein, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-04-20
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Chorismate mutase from Bartonella henselae str. Houston-1 in complex with malate
To be Published
3TSM
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CRYSTAL STRUCTURE OF INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE FROM BRUCELLA MELITENSIS
Descriptor:Indole-3-glycerol phosphate synthase, GLYCEROL, SULFATE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-09-13
Release date:2011-10-05
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of Indole-3-glycerol phosphate synthase from Brucella melitensis
To be Published
5P9F
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BTK IN COMPLEX WITH GDC-0834
Descriptor:Tyrosine-protein kinase BTK, N-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide, 1,2-ETHANEDIOL, ...
Authors:Gardberg, A.S.
Deposit date:2016-09-20
Release date:2017-05-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol. Pharmacol., 91, 2017
5P9G
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STRUCTURE OF BTK WITH RN486
Descriptor:Tyrosine-protein kinase BTK, 6-cyclopropyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridin-3-yl]phenyl]isoquinolin-1-one
Authors:Gardberg, A.S.
Deposit date:2016-09-20
Release date:2017-05-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol. Pharmacol., 91, 2017
5P9H
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BTK1 COCRYSTALLIZED WITH RN983
Descriptor:Tyrosine-protein kinase BTK, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one
Authors:Gardberg, A.S.
Deposit date:2016-09-20
Release date:2017-05-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol. Pharmacol., 91, 2017
5P9I
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BTK1 SOAKED WITH IBRUTINIB-REV
Descriptor:Tyrosine-protein kinase BTK, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, DIMETHYL SULFOXIDE
Authors:Gardberg, A.S.
Deposit date:2016-09-20
Release date:2017-05-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol. Pharmacol., 91, 2017
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