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1PB7
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH GLYCINE AT 1.35 ANGSTROMS RESOLUTION
Descriptor:N-methyl-D-aspartate Receptor Subunit 1, GLYCINE
Authors:Furukawa, H., Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB8
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-SERINE AT 1.45 ANGSTROMS RESOLUTION
Descriptor:N-methyl-D-aspartate Receptor Subunit 1, D-SERINE
Authors:Furukawa, H., Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB9
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-CYCLOSERINE AT 1.60 ANGSTROMS RESOLUTION
Descriptor:N-methyl-D-aspartate Receptor Subunit 1, (R)-4-AMINO-ISOXAZOLIDIN-3-ONE
Authors:Furukawa, H., Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PBQ
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (DCKA) AT 1.90 ANGSTROMS RESOLUTION
Descriptor:N-methyl-D-aspartate Receptor Subunit 1, 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
Authors:Furukawa, H., Gouaux, E.
Deposit date:2003-05-14
Release date:2003-07-29
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
2A5S
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CRYSTAL STRUCTURE OF THE NR2A LIGAND BINDING CORE IN COMPLEX WITH GLUTAMATE
Descriptor:N-methyl-D-aspartate receptor NMDAR2A subunit, GLUTAMIC ACID
Authors:Furukawa, H., Singh, S.K., Mancusso, R., Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2A5T
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CRYSTAL STRUCTURE OF THE NR1/NR2A LIGAND-BINDING CORES COMPLEX
Descriptor:N-methyl-D-aspartate receptor NMDAR1-4a subunit, N-methyl-D-aspartate receptor NMDAR2A subunit, GLYCINE, ...
Authors:Furukawa, H., Singh, S.K., Mancusso, R., Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
6CNA
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GLUN1-GLUN2B NMDA RECEPTORS WITH EXON 5
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2B, ...
Authors:Furukawa, H., Grant, T., Grigorieff, N.
Deposit date:2018-03-07
Release date:2018-10-03
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
6E7R
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HETERODIMER OF THE GLUN1B-GLUN2B NMDA RECEPTOR AMINO-TERMINAL DOMAINS BOUND TO ALLOSTERIC INHIBITOR 93-4
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2B, ...
Authors:Regan, M.C., Furukawa, H.
Deposit date:2018-07-27
Release date:2019-01-30
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Nat Commun, 10, 2019
2QTS
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STRUCTURE OF AN ACID-SENSING ION CHANNEL 1 AT 1.9 A RESOLUTION AND LOW PH
Descriptor:Acid-sensing ion channel, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Jasti, J., Furukawa, H., Gonzales, E.B., Gouaux, E.
Deposit date:2007-08-02
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
3H5V
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CRYSTAL STRUCTURE OF THE GLUR2-ATD
Descriptor:Glutamate receptor 2, N-ACETYL-D-GLUCOSAMINE
Authors:Jin, R., Singh, S.K., Gu, S., Furukawa, H., Sobolevsky, A., Zhou, J., Jin, Y., Gouaux, E.
Deposit date:2009-04-22
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal structure and association behaviour of the GluR2 amino-terminal domain.
Embo J., 28, 2009
3H5W
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CRYSTAL STRUCTURE OF THE GLUR2-ATD IN SPACE GROUP P212121 WITHOUT SOLVENT
Descriptor:Glutamate receptor 2
Authors:Jin, R., Singh, S.K., Gu, S., Furukawa, H., Sobolevsky, A., Zhou, J., Jin, Y., Gouaux, E.
Deposit date:2009-04-22
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.686 Å)
Cite:Crystal structure and association behaviour of the GluR2 amino-terminal domain.
Embo J., 28, 2009
3JPW
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CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAIN OF THE NMDA RECEPTOR SUBUNIT NR2B
Descriptor:Glutamate [NMDA] receptor subunit epsilon-2, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Karakas, E., Simorowski, N., Furukawa, H.
Deposit date:2009-09-04
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
3JPY
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CRYSTAL STRUCTURE OF THE ZINC-BOUND AMINO TERMINAL DOMAIN OF THE NMDA RECEPTOR SUBUNIT NR2B
Descriptor:Glutamate [NMDA] receptor subunit epsilon-2, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Karakas, E., Simorowski, N., Furukawa, H.
Deposit date:2009-09-04
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.209 Å)
Cite:Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
3OEK
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CRYSTAL STRUCTURE OF GLUN2D LIGAND-BINDING CORE IN COMPLEX WITH L-ASPARTATE
Descriptor:Glutamate [NMDA] receptor subunit epsilon-4, ASPARTIC ACID
Authors:Simorowski, N., Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3OEL
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CRYSTAL STRUCTURE OF GLUN2D LIGAND-BINDING CORE IN COMPLEX WITH D-GLUTAMATE
Descriptor:Glutamate [NMDA] receptor subunit epsilon-4, D-GLUTAMIC ACID
Authors:Simorowski, N., Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3OEM
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CRYSTAL STRUCTURE OF GLUN2D LIGAND-BINDING CORE IN COMPLEX WITH N-METHYL-D-ASPARTATE
Descriptor:Glutamate [NMDA] receptor subunit epsilon-4, N-methyl-D-aspartic acid
Authors:Simorowski, N., Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3OEN
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CRYSTAL STRUCTURE OF GLUN2D LIGAND-BINDING CORE IN COMPLEX WITH L-GLUTAMATE
Descriptor:Glutamate [NMDA] receptor subunit epsilon-4, GLUTAMIC ACID
Authors:Simorowski, N., Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3QEK
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CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAIN OF THE NMDA RECEPTOR SUBUNIT GLUN1
Descriptor:NMDA glutamate receptor subunit, POTASSIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Karakas, E., Simorowski, N., Furukawa, H.
Deposit date:2011-01-20
Release date:2011-06-15
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
3QEL
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CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH IFENPRODIL
Descriptor:NMDA glutamate receptor subunit, Glutamate [NMDA] receptor subunit epsilon-2, SODIUM ION, ...
Authors:Karakas, E., Simorowski, N., Furukawa, H.
Deposit date:2011-01-20
Release date:2011-06-15
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
3QEM
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CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH RO 25-6981
Descriptor:NMDA glutamate receptor subunit, Glutamate [NMDA] receptor subunit epsilon-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Karakas, E., Simorowski, N., Furukawa, H.
Deposit date:2011-01-20
Release date:2011-06-15
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (3.003 Å)
Cite:Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
4JWX
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GLUN2A LIGAND-BINDING CORE IN COMPLEX WITH PROPYL-NHP5G
Descriptor:GluN2A, (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid
Authors:Hansen, K.B., Tajima, N., Risgaard, R., Perszyk, R.E., Jorgensen, L., Vance, K.M., Ogden, K.K., Clausen, R.P., Furukawa, H., Traynelis, S.F.
Deposit date:2013-03-27
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
4JWY
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GLUN2D LIGAND-BINDING CORE IN COMPLEX WITH PROPYL-NHP5G
Descriptor:Glutamate receptor ionotropic, NMDA 2D, (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid
Authors:Hansen, K.B., Tajima, N., Risgaard, R., Perszyk, R.E., Jorgensen, L., Vance, K.M., Ogden, K.K., Clausen, R.P., Furukawa, H., Traynelis, S.F.
Deposit date:2013-03-27
Release date:2013-05-29
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
4NF4
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CRYSTAL STRUCTURE OF GLUN1/GLUN2A LIGAND-BINDING DOMAIN IN COMPLEX WITH DCKA AND GLUTAMATE
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A, ...
Authors:Annie, J., Tajima, N., Furukawa, H.
Deposit date:2013-10-30
Release date:2014-03-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
4NF5
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CRYSTAL STRUCTURE OF GLUN1/GLUN2A LIGAND-BINDING DOMAIN IN COMPLEX WITH GLYCINE AND D-AP5
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A, ...
Authors:Jespersen, A., Tajima, N., Furukawa, H.
Deposit date:2013-10-30
Release date:2014-03-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
4NF6
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CRYSTAL STRUCTURE OF GLUN1/GLUN2A LIGAND-BINDING DOMAIN IN COMPLEX WITH GLYCINE AND PPDA
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A, ...
Authors:Jespersen, A., Tajima, N., Furukawa, H.
Deposit date:2013-10-30
Release date:2014-03-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
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