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5Y25
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BU of 5y25 by Molmil
EGFR kinase domain mutant (T790M/L858R) with covalent ligand NS-062
Descriptor: (2R)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide, Epidermal growth factor receptor
Authors:Shiroishi, M, Abe, Y, Caaveiro, J.M.M, Sakamoto, S, Morimoto, S, Fuchida, H, Shindo, N, Ojida, A.
Deposit date:2017-07-24
Release date:2018-07-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Nat.Chem.Biol., 15, 2019

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