Author results

4AO6
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NATIVE STRUCTURE OF A NOVEL COLD-ADAPTED ESTERASE FROM AN ARCTIC INTERTIDAL METAGENOMIC LIBRARY
Descriptor:ESTERASE
Authors:Fu, J., Leiros, H.-K.S., Pascale, D.d., Johnson, K.A., Blencke, H.M., Landfald, B.
Deposit date:2012-03-23
Release date:2012-08-08
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Functional and Structural Studies of a Novel Cold-Adapted Esterase from an Arctic Intertidal Metagenomic Library.
Appl.Microbiol.Biotechnol., 97, 2013
4AO7
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ZINC BOUND STRUCTURE OF A NOVEL COLD-ADAPTED ESTERASE FROM AN ARCTIC INTERTIDAL METAGENOMIC LIBRARY
Descriptor:ESTERASE, ZINC ION
Authors:Fu, J., Leiros, H.-K.S., Pascale, D.d., Johnson, K.A., Blencke, H.M., Landfald, B.
Deposit date:2012-03-23
Release date:2012-08-08
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Functional and Structural Studies of a Novel Cold-Adapted Esterase from an Arctic Intertidal Metagenomic Library.
Appl.Microbiol.Biotechnol., 97, 2013
4AO8
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PEG-BOUND COMPLEX OF A NOVEL COLD-ADAPTED ESTERASE FROM AN ARCTIC INTERTIDAL METAGENOMIC LIBRARY
Descriptor:ESTERASE, DI(HYDROXYETHYL)ETHER
Authors:Fu, J., Leiros, H.-K.S., Pascale, D.d., Johnson, K.A., Blencke, H.M., Landfald, B.
Deposit date:2012-03-23
Release date:2012-08-08
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Functional and Structural Studies of a Novel Cold-Adapted Esterase from an Arctic Intertidal Metagenomic Library.
Appl.Microbiol.Biotechnol., 97, 2013
3IZ4
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MODIFIED E. COLI TMRNA IN THE RESUME STATE WITH THE TRNA-LIKE DOMAIN IN THE RIBOSOMAL P SITE INTERACTING WITH THE SMPB
Descriptor:Modified E. coli transfer-messenger RNA, SsrA-binding protein
Authors:Hashem, Y., Fu, J., Frank, J.
Deposit date:2010-09-21
Release date:2010-10-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (13.6 Å)
Cite:Visualizing the transfer-messenger RNA as the ribosome resumes translation.
Embo J., 29, 2010
4V6N
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STRUCTURAL CHARACTERIZATION OF MRNA-TRNA TRANSLOCATION INTERMEDIATES (50S RIBOSOME OF CLASS2 OF THE SIX CLASSES)
Descriptor:5S ribosomal RNA, 23S ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Agirrezabala, X., Liao, H., Schreiner, E., Fu, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-12-07
Release date:2014-07-09
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (12.1 Å)
Cite:Structural characterization of mRNA-tRNA translocation intermediates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4V6O
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STRUCTURAL CHARACTERIZATION OF MRNA-TRNA TRANSLOCATION INTERMEDIATES (CLASS 4A OF THE SIX CLASSES)
Descriptor:16S ribosomal RNA, A site tRNA, mRNA, ...
Authors:Agirrezabala, X., Liao, H., Schreiner, E., Fu, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-12-07
Release date:2014-07-09
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (14.7 Å)
Cite:Structural characterization of mRNA-tRNA translocation intermediates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4V6P
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STRUCTURAL CHARACTERIZATION OF MRNA-TRNA TRANSLOCATION INTERMEDIATES (CLASS 4B OF THE SIX CLASSES)
Descriptor:16S ribosomal RNA, A site tRNA, mRNA, ...
Authors:Agirrezabala, X., Liao, H., Schreiner, E., Fu, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-12-08
Release date:2014-07-09
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (13.5 Å)
Cite:Structural characterization of mRNA-tRNA translocation intermediates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4V6Q
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STRUCTURAL CHARACTERIZATION OF MRNA-TRNA TRANSLOCATION INTERMEDIATES (CLASS 5 OF THE SIX CLASSES)
Descriptor:16S ribosomal RNA, A site tRNA, mRNA, ...
Authors:Agirrezabala, X., Liao, H., Schreiner, E., Fu, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-12-08
Release date:2014-07-09
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Structural characterization of mRNA-tRNA translocation intermediates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4V6R
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STRUCTURAL CHARACTERIZATION OF MRNA-TRNA TRANSLOCATION INTERMEDIATES (CLASS 6 OF THE SIX CLASSES)
Descriptor:16S ribosomal RNA, A site tRNA, mRNA, ...
Authors:Agirrezabala, X., Liao, H., Schreiner, E., Fu, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-12-08
Release date:2014-07-09
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Structural characterization of mRNA-tRNA translocation intermediates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4V6S
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STRUCTURAL CHARACTERIZATION OF MRNA-TRNA TRANSLOCATION INTERMEDIATES (CLASS 3 OF THE SIX CLASSES)
Descriptor:5S ribomosomal RNA, 23S ribomosomal RNA, 50S ribosomal protein L1, ...
Authors:Agirrezabala, X., Liao, H., Schreiner, E., Fu, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-12-09
Release date:2014-07-09
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (13.1 Å)
Cite:Structural characterization of mRNA-tRNA translocation intermediates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4V8M
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HIGH-RESOLUTION CRYO-ELECTRON MICROSCOPY STRUCTURE OF THE TRYPANOSOMA BRUCEI RIBOSOME
Descriptor:40S RIBOSOMAL PROTEIN S3A, PUTATIVE, 40S RIBOSOMAL PROTEIN S4, ...
Authors:Hashem, Y., des Georges, A., Fu, J., Buss, S.N., Jossinet, F., Jobe, A., Zhang, Q., Liao, H.Y., Grassucci, R.A., Bajaj, C., Westhof, E., Madison-Antenucci, S., Frank, J.
Deposit date:2012-12-09
Release date:2014-07-09
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (5.57 Å)
Cite:High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
Nature, 494, 2013
2B8K
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12-SUBUNIT RNA POLYMERASE II
Descriptor:DNA-directed RNA polymerase II largest subunit, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 45 kDa polypeptide, ...
Authors:Meyer, P.A., Ye, P., Zhang, M., Suh, M.H., Fu, J.
Deposit date:2005-10-07
Release date:2006-06-20
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (4.15 Å)
Cite:Phasing RNA Polymerase II Using Intrinsically Bound Zn Atoms: An Updated Structural Model.
Structure, 14, 2006
3FKI
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12-SUBUNIT RNA POLYMERASE II REFINED WITH ZN-SAD DATA
Descriptor:DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Meyer, P.A., Ye, P., Suh, M.H., Zhang, M., Fu, J.
Deposit date:2008-12-16
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.88 Å)
Cite:Structure of the 12-Subunit RNA Polymerase II Refined with the Aid of Anomalous Diffraction Data
J.Biol.Chem., 284, 2009
3LD1
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CRYSTAL STRUCTURE OF IBV NSP2A
Descriptor:Replicase polyprotein 1a
Authors:Xu, Y., Cong, L., Wei, L., Fu, J., Chen, C., Yang, A., Tang, H., Bartlam, M., Rao, Z.
Deposit date:2010-01-12
Release date:2011-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:IBV nsp2 is an endosome-associated protein and viral pathogenicity factor
To be Published
4YTK
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STRUCTURE OF THE KOW1-LINKER1 DOMAIN OF TRANSCRIPTION ELONGATION FACTOR SPT5
Descriptor:Transcription elongation factor SPT5
Authors:Meyer, P.A., Li, S., Zhang, M., Yamada, K., Takagi, Y., Hartzog, G.A., Fu, J.
Deposit date:2015-03-17
Release date:2015-08-12
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.0904 Å)
Cite:Structures and Functions of the Multiple KOW Domains of Transcription Elongation Factor Spt5.
Mol.Cell.Biol., 35, 2015
4YTL
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STRUCTURE OF THE KOW2-KOW3 DOMAIN OF TRANSCRIPTION ELONGATION FACTOR SPT5.
Descriptor:Transcription elongation factor SPT5, SULFATE ION, GLYCEROL
Authors:Meyer, P.A., Li, S., ZHang, M., Yamada, K., Takagi, Y., Hartzog, G.A., Fu, J.
Deposit date:2015-03-17
Release date:2015-08-12
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structures and Functions of the Multiple KOW Domains of Transcription Elongation Factor Spt5.
Mol.Cell.Biol., 35, 2015
4TOT
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CRYSTAL STRUCTURE OF RAT CYCLOPHILIN D IN COMPLEX WITH A POTENT NONIMMUNOSUPPRESSIVE INHIBITOR
Descriptor:Peptidyl-prolyl cis-trans isomerase F, mitochondrial, nonimmunosuppressive inhibitor, ...
Authors:Knapp, M.S., Elling, R.A.
Deposit date:2014-06-06
Release date:2014-11-12
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
J.Med.Chem., 57, 2014
1I6H
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RNA POLYMERASE II ELONGATION COMPLEX
Descriptor:5'-D(P*AP*AP*AP*TP*GP*CP*CP*TP*GP*GP*TP*CP*T)-3', 5'-R(P*GP*AP*CP*CP*AP*GP*GP*CP*A)-3', DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT, ...
Authors:Gnatt, A.L., Cramer, P., Kornberg, R.D.
Deposit date:2001-03-02
Release date:2001-04-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.
Science, 292, 2001
4OAS
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CO-CRYSTAL STRUCTURE OF MDM2 (17-111) IN COMPLEX WITH COMPOUND 25
Descriptor:E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-1-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid, SULFATE ION
Authors:Huang, X.
Deposit date:2014-01-06
Release date:2014-02-19
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2-p53 Inhibitor in Clinical Development.
J.Med.Chem., 57, 2014
4OBA
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHIBITOR COMPOUND 4
Descriptor:E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid
Authors:Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
Deposit date:2014-01-07
Release date:2014-03-19
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction.
J.Med.Chem., 57, 2014
4OCC
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CO-CRYSTAL STRUCTURE OF MDM2(17-111) IN COMPLEX WITH COMPOUND 48
Descriptor:E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid
Authors:Huang, X.
Deposit date:2014-01-08
Release date:2014-04-02
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4ODE
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHIBITOR COMPOUND 4
Descriptor:E3 ubiquitin-protein ligase Mdm2, (2-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}-1,3-thiazol-5-yl)acetic acid, SULFATE ION
Authors:Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
Deposit date:2014-01-10
Release date:2014-04-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4ODF
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHIBITOR COMPOUND 47
Descriptor:E3 ubiquitin-protein ligase Mdm2, 6-{[(2S,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid
Authors:Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
Deposit date:2014-01-10
Release date:2014-04-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2006 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4OGN
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHBITOR COMPOUND 3
Descriptor:E3 ubiquitin-protein ligase Mdm2, 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid, SULFATE ION
Authors:Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
Deposit date:2014-01-16
Release date:2014-04-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.377 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4OGT
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHBITOR COMPOUND 46
Descriptor:E3 ubiquitin-protein ligase Mdm2, 6-{[(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, SULFATE ION
Authors:Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
Deposit date:2014-01-16
Release date:2014-04-02
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (1.5361 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
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