Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4JNM
DownloadVisualize
BU of 4jnm by Molmil
Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
Descriptor: 1,2-ETHANEDIOL, 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea, Nicotinamide phosphoribosyltransferase, ...
Authors:Gunzner-Toste, J, Zhao, G, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Fu, B, Han, B, Ho, Y, Kley, N, Liederer, B, Lin, J, Mukadam, S, O'Brien, T, Reynolds, D.J, Sharma, G, Skelton, N, Smith, C.C, Oh, A, Wang, W, Wang, Z, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X, Bair, K.W, Dragovich, P.S.
Deposit date:2013-03-15
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg.Med.Chem.Lett., 23, 2013
6MWY
DownloadVisualize
BU of 6mwy by Molmil
The Prp8 intein of Cryptococcus gattii
Descriptor: Pre-mRNA-processing-splicing factor 8
Authors:Li, Z, Fu, B, Green, C.M, Lang, Y, Zhang, J, Oven, T.S, Li, X, Callahan, B.P, Chaturvedi, S, Belfort, M, Liao, G, Li, H.
Deposit date:2018-10-30
Release date:2019-11-06
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (2.594 Å)
Cite:Cisplatin protects mice from challenge ofCryptococcus neoformansby targeting the Prp8 intein.
Emerg Microbes Infect, 8, 2019
6BJ9
DownloadVisualize
BU of 6bj9 by Molmil
Crystal structure of Acat2 thiolase from Ascaris suum
Descriptor: Acetyl-CoA acetyltransferase A, POTASSIUM ION
Authors:Blaisse, M.R, Fu, B, Chang, M.C.Y.
Deposit date:2017-11-05
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.53014076 Å)
Cite:Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases.
Biochemistry, 57, 2018
6BJA
DownloadVisualize
BU of 6bja by Molmil
Crystal structure of Acat5 thiolase from Ascaris suum in complex with coenzyme A
Descriptor: ACETATE ION, Acetyl-CoA acetyltransferase A, COENZYME A
Authors:Blaisse, M.R, Fu, B, Chang, M.C.Y.
Deposit date:2017-11-05
Release date:2018-02-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.60001445 Å)
Cite:Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases.
Biochemistry, 57, 2018
6BJB
DownloadVisualize
BU of 6bjb by Molmil
Crystal structure of Acat2-C91S thiolase from Ascaris suum in complex with propionyl-CoA and nitrate
Descriptor: Acetyl-CoA acetyltransferase A, NITRATE ION, propionyl Coenzyme A
Authors:Blaisse, M.R, Fu, B, Chang, M.C.Y.
Deposit date:2017-11-05
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.50000632 Å)
Cite:Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases.
Biochemistry, 57, 2018
4WQ6
DownloadVisualize
BU of 4wq6 by Molmil
The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)
Descriptor: 1,2-ETHANEDIOL, N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ...
Authors:Li, D, Wang, W.
Deposit date:2014-10-21
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg.Med.Chem.Lett., 25, 2015
6MYL
DownloadVisualize
BU of 6myl by Molmil
The Prp8 intein-cisplatin complex
Descriptor: PLATINUM (II) ION, Pre-mRNA-processing-splicing factor 8
Authors:Li, Z, Li, H.
Deposit date:2018-11-01
Release date:2019-11-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Cisplatin protects mice from challenge ofCryptococcus neoformansby targeting the Prp8 intein.
Emerg Microbes Infect, 8, 2019

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon