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4DO8
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BU of 4do8 by Molmil
Crystal structure of the muscarinic toxin MT1
Descriptor: ACETATE ION, Muscarinic toxin 1, THIOCYANATE ION
Authors:Fruchart-Gaillard, C, Mournier, G, Vera, L, Servent, D, Stura, E.A.
Deposit date:2012-02-09
Release date:2012-06-27
Last modified:2012-07-04
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
2VLW
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BU of 2vlw by Molmil
Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative.
Descriptor: ACETATE ION, MUSCARINIC M1-TOXIN1, SULFATE ION
Authors:Menez, R, Granata, V, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D, Stura, E.A.
Deposit date:2008-01-17
Release date:2008-10-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Different Interactions between Mt7 Toxin and the Human Muscarinic M1 Receptor in its Free and N-Methylscopolamine-Occupied States.
Mol.Pharmacol., 74, 2008
3FEV
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BU of 3fev by Molmil
Crystal structure of the chimeric muscarinic toxin MT7 with loop 1 from MT1.
Descriptor: Fusion of Muscarinic toxin 1, Muscarinic m1-toxin1, SULFATE ION
Authors:Stura, E.A, Menez, R, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D.
Deposit date:2008-12-01
Release date:2009-12-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
3NEQ
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BU of 3neq by Molmil
Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1
Descriptor: SULFATE ION, Three-finger muscarinic toxin 7
Authors:Stura, E.A, Servent, D, Menez, R, Mournier, G, Menez, A, Fruchart-Gaillard, C.
Deposit date:2010-06-09
Release date:2011-08-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
6TI9
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BU of 6ti9 by Molmil
Human transthyretin (TTR) complexed with (E)-3-(((3,5-dibromo-2-hydroxybenzylidene)amino)oxy)propanoic acid.
Descriptor: 3-[(~{E})-[3,5-bis(bromanyl)-2-oxidanyl-phenyl]methylideneamino]oxypropanoic acid, GLYCEROL, S-1,2-PROPANEDIOL, ...
Authors:Ciccone, L, Nencetti, S, Orlandini, E, Rossello, A, Legrand, P, Shepard, W.
Deposit date:2019-11-22
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.
Bioorg.Med.Chem., 28, 2020
6TJN
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BU of 6tjn by Molmil
Human transthyretin (TTR) complexed with (E)-3-(((4-hydroxybenzylidene)amino)oxy)propanoic acid
Descriptor: 3-[(~{E})-(4-hydroxyphenyl)methylideneamino]oxypropanoic acid, Transthyretin
Authors:Ciccone, L, Shepard, W, Nencetti, S, Orlandini, E, Rossello, A.
Deposit date:2019-11-26
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.
Bioorg.Med.Chem., 28, 2020
7Z60
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BU of 7z60 by Molmil
Human transthyretin (TTR) complexed with Quercetin 3-O-beta-D-galactoside
Descriptor: 1,2-ETHANEDIOL, 2-[3,4-bis(oxidanyl)phenyl]-3-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5,7-bis(oxidanyl)chromen-4-one, IMIDAZOLE, ...
Authors:Ciccone, L, Braca, A, Orlandini, E, Nencetti, S.
Deposit date:2022-03-10
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization
Crystals, 12, 2022
2H5F
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BU of 2h5f by Molmil
Denmotoxin: A the three-finger toxin from colubrid snake Boiga dendrophila with bird-specific activity
Descriptor: PHOSPHATE ION, POTASSIUM ION, SODIUM ION, ...
Authors:Pawlak, J, Kini, R.M, Stura, E.A.
Deposit date:2006-05-26
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity.
J.Biol.Chem., 281, 2006
5N5Q
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BU of 5n5q by Molmil
Human TTR altered conformation from soaking in iron chloride.
Descriptor: ACETATE ION, FE (III) ION, Transthyretin, ...
Authors:Ciccone, L, Savko, M, Shepard, W, Stura, E.A.
Deposit date:2017-02-14
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Copper mediated amyloid-beta binding to Transthyretin.
Sci Rep, 8, 2018
5N7C
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BU of 5n7c by Molmil
Human TTR altered conformation from soaking in CuCl2.
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, COPPER (II) ION, ...
Authors:Ciccone, L, Savko, M, Shepard, W, Stura, E.A.
Deposit date:2017-02-20
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Copper mediated amyloid-beta binding to Transthyretin.
Sci Rep, 8, 2018
5N62
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BU of 5n62 by Molmil
Human TTR crystals soaked in manganese chloride.
Descriptor: MANGANESE (II) ION, Transthyretin
Authors:Ciccone, L, Savko, M, Shepard, W, Stura, E.A.
Deposit date:2017-02-14
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Copper mediated amyloid-beta binding to Transthyretin.
Sci Rep, 8, 2018
2H7Z
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BU of 2h7z by Molmil
Crystal structure of irditoxin
Descriptor: Irditoxin subunit A, Irditoxin subunit B
Authors:Pawlak, J, Kini, R.M, Stura, E.A, Le Du, M.H.
Deposit date:2006-06-06
Release date:2006-08-29
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity.
Faseb J., 23, 2009

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