1XBA | | CRYSTAL STRUCTURE OF APO SYK TYROSINE KINASE DOMAIN | | 分子名称: | Tyrosine-protein kinase SYK | | 著者 | Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G. | | 登録日 | 2004-08-30 | | 公開日 | 2004-11-02 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
J.Biol.Chem., 279, 2004
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1XBB | | CRYSTAL STRUCTURE OF THE SYK TYROSINE KINASE DOMAIN WITH GLEEVEC | | 分子名称: | Tyrosine-protein kinase SYK, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | | 著者 | Nienaber, V.L., Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G. | | 登録日 | 2004-08-30 | | 公開日 | 2004-11-02 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase
J.Biol.Chem., 279, 2004
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1XBC | | CRYSTAL STRUCTURE OF THE SYK TYROSINE KINASE DOMAIN WITH STAUROSPORIN | | 分子名称: | Tyrosine-protein kinase SYK, STAUROSPORINE | | 著者 | Badger, J., Atwell, S., Adams, J.M., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G. | | 登録日 | 2004-08-30 | | 公開日 | 2004-11-02 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase
J.Biol.Chem., 279, 2004
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5DI8 | | FC KNOB-HOLE HETERODIMER T366W + T366S/L368A/Y407V | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-08-31 | | 公開日 | 2016-03-30 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJ0 | | FC HETERODIMER DESIGN 11.2 Y349S/K370Y + E357D/S364Q | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-01 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJ2 | | FC HETERODIMER DESIGN 7.4 Y407A + T366V/K409V | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-01 | | 公開日 | 2016-03-30 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJ6 | | FC HETERODIMER DESIGN 6.1 F405W/Y407A + T366M | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-01 | | 公開日 | 2016-03-30 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJ8 | | FC HETERODIMER DESIGN 7.7 D399M/Y407A + T366V/K409I | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-01 | | 公開日 | 2016-03-30 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJA | | FC HETERODIMER DESIGN 9.1 Y407M + T366I | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-01 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJC | | FC HETERODIMER DESIGN 8.1 L368V/Y407A + T366V/K409F | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-01 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJD | | FC HETERODIMER DESIGN 5.1 T366V + Y407F | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJX | | FC HETERODIMER DESIGN 2.9 L368M/K370E + E357A/S364G | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJY | | FC HETERODIMER DESIGN 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DJZ | | FC HETERODIMER DESIGN 7.8 D399M/Y407A + T366V/K409V | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DK0 | | FC HETERODIMER DESIGN 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DK2 | | FC HETERODIMER E356K/D399K + K392D/K409D | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DVK | | FC DESIGN 7.7 B CHAIN HOMODIMER T366V/K409I | | 分子名称: | Ig gamma-1 chain C region | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-21 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DVL | | FC DESIGN 20.8.37 A CHAIN HOMODIMER Y349S/T366M/K370Y/K409V | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-21 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-07-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DVM | | FC DESIGN 20.8.37 B CHAIN HOMODIMER E357D/S364R/Y407A | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-21 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-07-06 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DVN | | FC K392D/K409D HOMODIMER | | 分子名称: | Ig gamma-1 chain C region, Fc-III peptide | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-21 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-07-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5DVO | | FC K392D/K409D HOMODIMER | | 分子名称: | Ig gamma-1 chain C region, SULFATE ION | | 著者 | Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B. | | 登録日 | 2015-09-21 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5VR9 | | CH1/CKAPPA FAB BASED ON MATUZUMAB | | 分子名称: | CH1/Ckappa Fab heavy chain, CH1/Ckappa Fab light chain | | 著者 | Hendle, J. | | 登録日 | 2017-05-10 | | 公開日 | 2017-08-02 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies.
Protein Sci., 26, 2017
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5VSH | | CH1/CLAMBDA FAB BASED ON PERTUZUMAB | | 分子名称: | CH1/Clambda Fab heavy chain, CH1/Clambda Fab light chain, SULFATE ION | | 著者 | Hendle, J. | | 登録日 | 2017-05-11 | | 公開日 | 2017-08-02 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies.
Protein Sci., 26, 2017
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5VSI | | CH1/CKAPPA FAB MUTANT 15.1 | | 分子名称: | CH1/Ckappa Fab heavy chain, CH1/Ckappa Fab light chain, SULFATE ION, ... | | 著者 | Hendle, J. | | 登録日 | 2017-05-11 | | 公開日 | 2017-08-02 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies.
Protein Sci., 26, 2017
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3DKC | | STRUCTURE OF MET RECEPTOR TYROSINE KINASE IN COMPLEX WITH ATP | | 分子名称: | Hepatocyte growth factor receptor, MAGNESIUM ION, CHLORIDE ION, ... | | 著者 | Hendle, J. | | 登録日 | 2008-06-24 | | 公開日 | 2009-07-07 | | 最終更新日 | 2015-04-22 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
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