Author results

4ASI
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CRYSTAL STRUCTURE OF HUMAN ACACA C-TERMINAL DOMAIN
Descriptor:ACETYL-COA CARBOXYLASE 1
Authors:Froese, D.S., Muniz, J.R.C., Kiyani, W., Krojer, T., Vollmar, M., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Oppermann, U., Yue, W.W.
Deposit date:2012-05-01
Release date:2012-08-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Acaca C-Terminal Domain
To be Published
4BZY
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CRYSTAL STRUCTURE OF HUMAN GLYCOGEN BRANCHING ENZYME (GBE1)
Descriptor:1,4-ALPHA-GLUCAN-BRANCHING ENZYME
Authors:Froese, D.S., Krojer, T., Goubin, S., Strain-Damerell, C., Mahajan, P., von Delft, F., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Yue, W.W.
Deposit date:2013-07-30
Release date:2013-09-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis of Glycogen Branching Enzyme Deficiency and Pharmacologic Rescue by Rational Peptide Design.
Hum.Mol.Genet., 24, 2015
4HAS
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CRYSTAL STRUCTURE OF PX DOMAIN OF HUMAN SORTING NEXIN SNX27
Descriptor:Sorting nexin-27, CITRIC ACID, 1,2-ETHANEDIOL
Authors:Froese, D.S., Krojer, T., Strain-Damerell, C., Allerston, C., Kiyani, W., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Bountra, C., Edwards, A., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2012-09-27
Release date:2013-04-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of PX domain of human sorting nexin SNX27
To be Published
2WWW
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CRYSTAL STRUCTURE OF METHYLMALONIC ACIDEMIA TYPE A PROTEIN
Descriptor:METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL, NONAETHYLENE GLYCOL, ...
Authors:Muniz, J.R.C., Gileadi, C., Froese, D.S., Yue, W.W., Pike, A.C.W., von Delft, F., Kochan, G., Sethi, R., Chaikuad, A., Pilka, E., Picaud, S., Phillips, C., Guo, K., Krysztofinska, E., Bray, J., Burgess-Brown, N., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gravel, R.A., Kavanagh, K.L., Oppermann, U.
Deposit date:2009-10-30
Release date:2009-11-17
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIJ
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, 5'-DEOXYADENOSINE, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Vollmar, M., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIQ
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN AND MALONYL-COA
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, COBALAMIN, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Ugochukwu, E., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
3SOM
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CRYSTAL STRUCTURE OF HUMAN MMACHC
Descriptor:Methylmalonic aciduria and homocystinuria type C protein, COBALAMIN, CITRATE ANION, ...
Authors:Krojer, T., Froese, D.S., von Delft, F., Muniz, J.R., Gileadi, C., Vollmar, M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Gravel, R.A., Yue, W.W., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-06-30
Release date:2011-07-27
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Biochemistry, 51, 2012
5A4R
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CRYSTAL STRUCTURE OF A VITAMIN B12 TRAFFICKING PROTEIN
Descriptor:METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE D HOMOLOG, MITOCHONDRIAL
Authors:Kopec, J., Fitzpatrick, F., Froese, D.S., Velupillai, S., Nowak, R., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Fowler, B., Baumgartner, M.R., Yue, W.W.
Deposit date:2015-06-11
Release date:2015-10-28
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Insights Into the Mmachc-Mmadhc Protein Complex Involved in Vitamin B12 Trafficking.
J.Biol.Chem., 290, 2015
6FCX
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STRUCTURE OF HUMAN 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR)
Descriptor:Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Kopec, J., Bezerra, G.A., Oberholzer, A.E., Rembeza, E., Sorrell, F.J., Chalk, R., Borkowska, O., Ellis, K., Kupinska, K., Krojer, T., Burgess-Brown, N., Von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Froese, D.S., Baumgartner, M., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2017-12-21
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Nat Commun, 9, 2018
6FNU
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STRUCTURE OF S. CEREVISIAE METHYLENETETRAHYDROFOLATE REDUCTASE 1, CATALYTIC DOMAIN
Descriptor:Methylenetetrahydrofolate reductase 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kopec, J., Rembeza, E., Bezerra, G.A., Newman, J., Bountra, C., Froese, D.S., Baumgartner, M., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-07
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Nat Commun, 9, 2018
2YL2
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CRYSTAL STRUCTURE OF HUMAN ACETYL-COA CARBOXYLASE 1, BIOTIN CARBOXYLASE (BC) DOMAIN
Descriptor:ACETYL-COA CARBOXYLASE 1
Authors:Muniz, J.R.C., Froese, D.S., Krysztofinska, E., Vollmar, M., Beltrami, A., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Yue, W.W., Oppermann, U.
Deposit date:2011-05-31
Release date:2011-06-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Acetyl-Coa Carboxylase 1, Biotin Carboxylase (Bc) Domain
To be Published
2YPS
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CRYSTAL STRUCTURE OF THE PX DOMAIN OF HUMAN SORTING NEXIN 3
Descriptor:SORTING NEXIN-3
Authors:Canning, P., Kiyani, W., Froese, D.S., Krojer, T., Strain-Damerell, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Yue, W.W.
Deposit date:2012-10-31
Release date:2013-03-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Px Domain of Human Sorting Nexin 3
To be Published
3Q4S
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1), APO FORM
Descriptor:Glycogenin-1, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Chaikuad, A., Froese, D.S., Yue, W.W., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, O., Structural Genomics Consortium (SGC)
Deposit date:2010-12-24
Release date:2011-02-09
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QVB
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE AND UDP
Descriptor:Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Chaikuad, A., Froese, D.S., Yue, W.W., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-02-25
Release date:2011-03-23
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RMU
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA EPIMERASE, MCEE
Descriptor:Methylmalonyl-CoA epimerase, mitochondrial, COBALT (II) ION, ...
Authors:Chaikuad, A., Krysztofinska, E., Froese, D.S., Yue, W.W., Vollmar, M., Muniz, J.R.C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-04-21
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human Methylmalonyl-CoA epimerase, MCEE
To be Published
3RMV
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) T83M MUTANT COMPLEXED WITH MANGANESE AND UDP
Descriptor:Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Chaikuad, A., Froese, D.S., Yue, W.W., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-04-21
Release date:2011-05-18
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RMW
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) T83M MUTANT COMPLEXED WITH MANGANESE AND UDP-GLUCOSE
Descriptor:Glycogenin-1, URIDINE-5'-DIPHOSPHATE-GLUCOSE, MANGANESE (II) ION, ...
Authors:Chaikuad, A., Froese, D.S., Yue, W.W., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-04-21
Release date:2011-05-11
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T7M
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE AND UDP, IN A TRICLINIC CLOSED FORM
Descriptor:Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-07-30
Release date:2011-08-31
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T7N
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE AND UDP, IN A MONOCLINIC CLOSED FORM
Descriptor:Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-07-30
Release date:2011-08-31
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T7O
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE, UDP-GLUCOSE AND GLUCOSE
Descriptor:Glycogenin-1, ALPHA-D-GLUCOSE, MANGANESE (II) ION, ...
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-07-30
Release date:2011-08-31
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U2T
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE
Descriptor:Glycogenin-1, MANGANESE (II) ION, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2011-11-02
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U2U
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE, UDP AND MALTOTETRAOSE
Descriptor:Glycogenin-1, ALPHA-D-GLUCOSE, MANGANESE (II) ION, ...
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2011-11-02
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U2V
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE, UDP AND MALTOHEXAOSE
Descriptor:Glycogenin-1, ALPHA-D-GLUCOSE, MANGANESE (II) ION, ...
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2011-12-07
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U2W
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE AND GLUCOSE OR A GLUCAL SPECIES
Descriptor:Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2011-11-02
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U2X
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) COMPLEXED WITH MANGANESE, UDP AND 1'-DEOXYGLUCOSE
Descriptor:Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2011-11-02
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese, UDP and 1'-deoxyglucose
To be Published
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