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4HAS
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BU of 4has by Molmil
Crystal structure of PX domain of human sorting nexin SNX27
Descriptor: 1,2-ETHANEDIOL, CITRIC ACID, Sorting nexin-27
Authors:Froese, D.S, Krojer, T, Strain-Damerell, C, Allerston, C, Kiyani, W, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Bountra, C, Edwards, A, Yue, W.W, Structural Genomics Consortium (SGC)
Deposit date:2012-09-27
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of PX domain of human sorting nexin SNX27
To be Published
4ASI
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BU of 4asi by Molmil
Crystal structure of human ACACA C-terminal domain
Descriptor: ACETYL-COA CARBOXYLASE 1
Authors:Froese, D.S, Muniz, J.R.C, Kiyani, W, Krojer, T, Vollmar, M, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, Yue, W.W.
Deposit date:2012-05-01
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Acaca C-Terminal Domain
To be Published
4BZY
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BU of 4bzy by Molmil
Crystal structure of human glycogen branching enzyme (GBE1)
Descriptor: 1,4-ALPHA-GLUCAN-BRANCHING ENZYME
Authors:Froese, D.S, Krojer, T, Goubin, S, Strain-Damerell, C, Mahajan, P, von Delft, F, Burgess-Brown, N, Bountra, C, Arrowsmith, C.H, Edwards, A, Yue, W.W.
Deposit date:2013-07-30
Release date:2013-09-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis of Glycogen Branching Enzyme Deficiency and Pharmacologic Rescue by Rational Peptide Design.
Hum.Mol.Genet., 24, 2015
6FCX
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BU of 6fcx by Molmil
Structure of human 5,10-methylenetetrahydrofolate reductase (MTHFR)
Descriptor: CITRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase, ...
Authors:Kopec, J, Bezerra, G.A, Oberholzer, A.E, Rembeza, E, Sorrell, F.J, Chalk, R, Borkowska, O, Ellis, K, Kupinska, K, Krojer, T, Burgess-Brown, N, Von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Froese, D.S, Baumgartner, M, Yue, W.W, Structural Genomics Consortium (SGC)
Deposit date:2017-12-21
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Nat Commun, 9, 2018
6FNU
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BU of 6fnu by Molmil
Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase 1
Authors:Kopec, J, Rembeza, E, Bezerra, G.A, Newman, J, Bountra, C, Froese, D.S, Baumgartner, M, Yue, W.W, Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-07
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Nat Commun, 9, 2018
5A4R
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BU of 5a4r by Molmil
Crystal structure of a vitamin B12 trafficking protein
Descriptor: METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE D HOMOLOG, MITOCHONDRIAL
Authors:Kopec, J, Fitzpatrick, F, Froese, D.S, Velupillai, S, Nowak, R, Chalk, R, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Fowler, B, Baumgartner, M.R, Yue, W.W.
Deposit date:2015-06-11
Release date:2015-10-28
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Insights Into the Mmachc-Mmadhc Protein Complex Involved in Vitamin B12 Trafficking.
J.Biol.Chem., 290, 2015
2WWW
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BU of 2www by Molmil
Crystal Structure of Methylmalonic Acidemia Type A Protein
Descriptor: GUANOSINE-5'-DIPHOSPHATE, METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL, ...
Authors:Muniz, J.R.C, Gileadi, C, Froese, D.S, Yue, W.W, Pike, A.C.W, von Delft, F, Kochan, G, Sethi, R, Chaikuad, A, Pilka, E, Picaud, S, Phillips, C, Guo, K, Krysztofinska, E, Bray, J, Burgess-Brown, N, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gravel, R.A, Kavanagh, K.L, Oppermann, U.
Deposit date:2009-10-30
Release date:2009-11-17
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIQ
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BU of 2xiq by Molmil
Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin and malonyl-CoA
Descriptor: 5'-DEOXYADENOSINE, COBALAMIN, MALONYL-COENZYME A, ...
Authors:Yue, W.W, Froese, D.S, Kochan, G, Chaikuad, A, Krojer, T, Muniz, J, Ugochukwu, E, Arrowsmith, C, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIJ
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BU of 2xij by Molmil
Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-DEOXYADENOSINE, ...
Authors:Yue, W.W, Froese, D.S, Kochan, G, Chaikuad, A, Krojer, T, Muniz, J, Vollmar, M, Arrowsmith, C, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
3SOM
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BU of 3som by Molmil
crystal structure of human MMACHC
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-ETHANETHIOL, 5'-DEOXYADENOSINE, ...
Authors:Krojer, T, Froese, D.S, von Delft, F, Muniz, J.R, Gileadi, C, Vollmar, M, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Gravel, R.A, Yue, W.W, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2011-06-30
Release date:2011-07-27
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Biochemistry, 51, 2012
8QA5
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BU of 8qa5 by Molmil
MTHFR + SAH asymmetric dis-inhibited state
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase (NADPH), S-ADENOSYL-L-HOMOCYSTEINE
Authors:Blomgren, L.K.M, Yue, W.W, Froese, D.S, McCorvie, T.J.
Deposit date:2023-08-22
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase
To Be Published
8QA6
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BU of 8qa6 by Molmil
MTHFR + SAM inhibited state
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase (NADPH), S-ADENOSYLMETHIONINE
Authors:Blomgren, L.K.M, Yue, W.W, Froese, D.S, McCorvie, T.J.
Deposit date:2023-08-22
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase
To Be Published
8QA4
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BU of 8qa4 by Molmil
MTHFR + SAH symmetric dis-inhibited state
Descriptor: Methylenetetrahydrofolate reductase (NADPH), S-ADENOSYL-L-HOMOCYSTEINE
Authors:Blomgren, L.K.M, Yue, W.W, Froese, D.S, McCorvie, T.J.
Deposit date:2023-08-22
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase
To Be Published
4UEG
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BU of 4ueg by Molmil
Crystal structure of human glycogenin-2 catalytic domain
Descriptor: GLYCOGENIN-2, MAGNESIUM ION
Authors:Fairhead, M, Strain-Damerell, C, Krojer, T, Froese, D.S, Kopec, J, Nowak, R, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
Deposit date:2014-12-17
Release date:2014-12-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal Structure of Human Glycogenin-2 Catalytic Domain
To be Published
6QH4
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BU of 6qh4 by Molmil
Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
Descriptor: COBALT (II) ION, Methylmalonyl-CoA epimerase, mitochondrial
Authors:Bailey, H.J, Chaikuid, A, Krysztofinska, E, Froese, D.S, Sorrell, F.J, Diaz-Saez, L, Kennedy, E, Edwards, A.M, Bountra, C, Yue, W.W.
Deposit date:2019-01-15
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.922 Å)
Cite:Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
To Be Published
7Q0S
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BU of 7q0s by Molmil
Human GYS1-GYG1 complex inhibited-like state bound to glucose-6-phosphate
Descriptor: 6-O-phosphono-alpha-D-glucopyranose, Glycogen [starch] synthase, muscle, ...
Authors:McCorvie, T.J, Shrestha, L, Froese, D.S, Ferreira, I.M, Yue, W.W.
Deposit date:2021-10-16
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
Nat.Struct.Mol.Biol., 29, 2022
7Q0B
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BU of 7q0b by Molmil
Human GYS1-GYG1 complex inhibited state
Descriptor: Glycogen [starch] synthase, muscle, Glycogenin-1
Authors:McCorvie, T.J, Shrestha, L, Froese, D.S, Ferreira, I.M, Yue, W.W.
Deposit date:2021-10-14
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
Nat.Struct.Mol.Biol., 29, 2022
7Q12
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BU of 7q12 by Molmil
Human GYS1-GYG1 complex activated state bound to glucose-6-phosphate
Descriptor: 6-O-phosphono-alpha-D-glucopyranose, Glycogen [starch] synthase, muscle, ...
Authors:McCorvie, T.J, Shrestha, L, Froese, D.S, Ferreira, I.M, Yue, W.W.
Deposit date:2021-10-17
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
Nat.Struct.Mol.Biol., 29, 2022
7Q13
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BU of 7q13 by Molmil
Human GYS1-GYG1 complex activated state bound to glucose-6-phosphate, uridine diphosphate, and glucose
Descriptor: 6-O-phosphono-alpha-D-glucopyranose, Glycogen [starch] synthase, muscle, ...
Authors:McCorvie, T.J, Shrestha, L, Froese, D.S, Ferreira, I.M, Yue, W.W.
Deposit date:2021-10-17
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
Nat.Struct.Mol.Biol., 29, 2022
5CLW
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BU of 5clw by Molmil
Crystal structure of human glycogen branching enzyme (GBE1) in complex with maltoheptaose
Descriptor: 1,4-alpha-glucan-branching enzyme, SODIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Krojer, T, Froese, D.S, Goubin, S, Strain-Damerell, C, Mahajan, P, Burgess-Brown, N, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Yue, W, Structural Genomics Consortium (SGC)
Deposit date:2015-07-16
Release date:2015-10-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human glycogen branching enzyme (GBE1) in complex with maltoheptaose
To be published
5CLT
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BU of 5clt by Molmil
Crystal structure of human glycogen branching enzyme (GBE1) in complex with acarbose
Descriptor: 1,4-alpha-glucan-branching enzyme, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Krojer, T, Froese, D.S, Goubin, S, Strain-Damerell, C, Mahajan, P, Burgess-Brown, N, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Yue, W, Structural Genomics Consortium (SGC)
Deposit date:2015-07-16
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Crystal structure of human glycogen branching enzyme (GBE1) in complex with acarbose
To be published
3Q4S
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BU of 3q4s by Molmil
Crystal Structure of Human Glycogenin-1 (GYG1), apo form
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Glycogenin-1
Authors:Chaikuad, A, Froese, D.S, Yue, W.W, Krysztofinska, E, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Oppermann, O, Structural Genomics Consortium (SGC)
Deposit date:2010-12-24
Release date:2011-02-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QVB
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BU of 3qvb by Molmil
Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP
Descriptor: 1,2-ETHANEDIOL, Glycogenin-1, MANGANESE (II) ION, ...
Authors:Chaikuad, A, Froese, D.S, Yue, W.W, Krysztofinska, E, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2011-02-25
Release date:2011-03-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RMW
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BU of 3rmw by Molmil
Crystal Structure of Human Glycogenin-1 (GYG1) T83M mutant complexed with manganese and UDP-glucose
Descriptor: 1,2-ETHANEDIOL, Glycogenin-1, MAGNESIUM ION, ...
Authors:Chaikuad, A, Froese, D.S, Yue, W.W, Krysztofinska, E, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2011-04-21
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YL2
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BU of 2yl2 by Molmil
Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain
Descriptor: ACETYL-COA CARBOXYLASE 1
Authors:Muniz, J.R.C, Froese, D.S, Krysztofinska, E, Vollmar, M, Beltrami, A, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Yue, W.W, Oppermann, U.
Deposit date:2011-05-31
Release date:2011-06-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Acetyl-Coa Carboxylase 1, Biotin Carboxylase (Bc) Domain
To be Published

 

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