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3EF6
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CRYSTAL STRUCTURE OF TOLUENE 2,3-DIOXYGENASE REDUCTASE
分子名称:Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
著者Friemann, R., Lee, K., Brown, E.N., Gibson, D.T., Eklund, H., Ramaswamy, S.
登録日2008-09-08
公開日2009-03-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system
Acta Crystallogr.,Sect.D, 65, 2009
3EN1
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CRYSTAL STRUCTURE OF TOLUENE 2,3-DIOXYGENASE
分子名称:Benzene 1,2-dioxygenase subunit alpha, Benzene 1,2-dioxygenase subunit beta, FE (II) ION, ...
著者Friemann, R., Lee, K., Brown, E.N., Gibson, D.T., Eklund, H., Ramaswamy, S.
登録日2008-09-25
公開日2009-03-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system
Acta Crystallogr.,Sect.D, 65, 2009
3EQQ
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APO TOLUENE 2,3-DIOXYGENASE
分子名称:Benzene 1,2-dioxygenase subunit alpha, Benzene 1,2-dioxygenase subunit beta, FE2/S2 (INORGANIC) CLUSTER, ...
著者Friemann, R., Lee, K., Brown, E.N., Gibson, D.T., Eklund, H., Ramaswamy, S.
登録日2008-10-01
公開日2009-03-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system
Acta Crystallogr.,Sect.D, 65, 2009
1R26
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CRYSTAL STRUCTURE OF THIOREDOXIN FROM TRYPANOSOMA BRUCEI BRUCEI
分子名称:Thioredoxin
著者Friemann, R., Schmidt, H., Ramaswamy, S., Forstner, M., Krauth-Siegel, R.L., Eklund, H.
登録日2003-09-26
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of thioredoxin from Trypanosoma brucei brucei
FEBS Lett., 554, 2003
2BMO
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THE CRYSTAL STRUCTURE OF NITROBENZENE DIOXYGENASE
分子名称:OXYGENASE-ALPHA NBDO, OXYGENASE-BETA NBDO, FE2/S2 (INORGANIC) CLUSTER, ...
著者Friemann, R., Ivkovic-Jensen, M.M., Lessner, D.J., Yu, C., Gibson, D.T., Parales, R.E., Eklund, H., Ramaswamy, S.
登録日2005-03-15
公開日2005-05-04
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase.
J. Mol. Biol., 348, 2005
2BMQ
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THE CRYSTAL STRUCTURE OF NITROBENZENE DIOXYGENASE IN COMPLEX WITH NITROBENZENE
分子名称:OXYGENASE-ALPHA NBDO, OXYGENASE-BETA NBDO, FE2/S2 (INORGANIC) CLUSTER, ...
著者Friemann, R., Ivkovic-Jensen, M.M., Lessner, D.J., Yu, C., Gibson, D.T., Parales, R.E., Eklund, H., Ramaswamy, S.
登録日2005-03-15
公開日2005-05-04
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase.
J. Mol. Biol., 348, 2005
2BMR
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THE CRYSTAL STRUCTURE OF NITROBENZENE DIOXYGENASE IN COMPLEX WITH 3- NITROTOLUENE
分子名称:OXYGENASE-ALPHA NBDO, OXYGENASE-BETA NBDO, FE2/S2 (INORGANIC) CLUSTER, ...
著者Friemann, R., Ivkovic-Jensen, M.M., Lessner, D.J., Yu, C., Gibson, D.T., Parales, R.E., Eklund, H., Ramaswamy, S.
登録日2005-03-15
公開日2005-05-04
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase.
J. Mol. Biol., 348, 2005
3DQY
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CRYSTAL STRUCTURE OF TOLUENE 2,3-DIOXYGENASE FERREDOXIN
分子名称:Toluene 1,2-dioxygenase system ferredoxin subunit, FE2/S2 (INORGANIC) CLUSTER
著者Friemann, R., Lee, K., Brown, E.N., Gibson, D.T., Eklund, H., Ramaswamy, S.
登録日2008-07-10
公開日2009-03-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system
Acta Crystallogr.,Sect.D, 65, 2009
5NV9
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SUBSTRATE-BOUND OUTWARD-OPEN STATE OF A NA+-COUPLED SIALIC ACID SYMPORTER REVEALS A NOVEL NA+-SITE
分子名称:Putative sodium:solute symporter, SODIUM ION, 5-N-ACETYL-BETA-D-NEURAMINIC ACID, ...
著者Wahlgren, W.Y., North, R.A., Dunevall, E., Paz, A., Goyal, P., Bisignano, P., Grabe, M., Dobson, R., Abramson, J., Ramaswamy, S., Friemann, R.
登録日2017-05-03
公開日2018-04-04
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Nat Commun, 9, 2018
5NVA
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SUBSTRATE-BOUND OUTWARD-OPEN STATE OF A NA+-COUPLED SIALIC ACID SYMPORTER REVEALS A NOVEL NA+-SITE
分子名称:Putative sodium:solute symporter, SODIUM ION, 5-N-ACETYL-BETA-D-NEURAMINIC ACID
著者Wahlgren, W.Y., North, R.A., Dunevall, E., Goyal, P., Grabe, M., Dobson, R., Abramson, J., Ramaswamy, S., Friemann, R.
登録日2017-05-03
公開日2018-04-04
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Nat Commun, 9, 2018
3ZOJ
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HIGH-RESOLUTION STRUCTURE OF PICHIA PASTORIS AQUAPORIN AQY1 AT 0.88 A
分子名称:AQUAPORIN, B-OCTYLGLUCOSIDE, CHLORIDE ION
著者Kosinska-Eriksson, U., Fischer, G., Friemann, R., Enkavi, G., Tajkhorshid, E., Neutze, R.
登録日2013-02-21
公開日2013-06-26
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (0.88 Å)
主引用文献Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions
Science, 340, 2013
5NCK
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THE CRYSTAL STRUCTURE OF N-ACETYLMANNOSAMINE KINASE IN FUSOBACTERIUM NUCLEATUM
分子名称:N-acetylmannosamine kinase
著者Caing-Carlsson, R., Sharma, A., Friemann, R., Ramaswamy, S.
登録日2017-03-06
公開日2017-06-28
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Crystal structure of N-acetylmannosamine kinase from Fusobacterium nucleatum.
Acta Crystallogr F Struct Biol Commun, 73, 2017
2QPZ
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NAPHTHALENE 1,2-DIOXYGENASE RIESKE FERREDOXIN
分子名称:Naphthalene 1,2-dioxygenase system ferredoxin subunit, FE2/S2 (INORGANIC) CLUSTER
著者Brown, E.N., Ramaswamy, S., Karlsson, A., Friemann, R., Parales, J.V., Parales, R., Gibson, D.T.
登録日2007-07-25
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Determining Rieske cluster reduction potentials.
J.Biol.Inorg.Chem., 13, 2008
6F2U
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POTENT AND SELECTIVE ALDO-KETO REDUCTASE 1C3 (AKR1C3) INHIBITORS BASED ON THE BENZOISOXAZOLE MOIETY: APPLICATION OF A BIOISOSTERIC SCAFFOLD HOPPING APPROACH TO FLUFENAMIC ACID
分子名称:Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(4-methoxyphenyl)methyl]-5-oxidanyl-~{N}-[3-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxamide
著者Goyal, P., Wahlgren, W.Y., Friemann, R.
登録日2017-11-27
公開日2018-04-04
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.
Eur J Med Chem, 150, 2018
6F78
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POTENT AND SELECTIVE ALDO-KETO REDUCTASE 1C3 (AKR1C3) INHIBITORS BASED ON THE BENZOISOXAZOLE MOIETY: APPLICATION OF A BIOISOSTERIC SCAFFOLD HOPPING APPROACH TO FLUFENAMIC ACID
分子名称:Aldo-keto reductase family 1 member C3, 4-[[3,5-bis(trifluoromethyl)phenyl]amino]-1,2-benzoxazol-3-one, CHLORIDE ION, ...
著者Goyal, P., Wahlgren, W.Y., Friemann, R.
登録日2017-12-07
公開日2018-04-04
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.
Eur J Med Chem, 150, 2018
6GXK
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CRYSTAL STRUCTURE OF ALDO-KETO REDUCTASE 1C3 (AKR1C3) COMPLEXED WITH INHIBITOR.
分子名称:Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]methyl]-1,2,5-oxadiazol-3-one, ...
著者Goyal, P., Wahlgren, W.Y., Friemann, R.
登録日2018-06-27
公開日2019-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Effective Application of a Bioisosteric Scaffold Hopping Approach to the Indomethacine modulation: design of new and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors
To Be Published
1GQ8
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PECTIN METHYLESTERASE FROM CARROT
分子名称:PECTINESTERASE, CACODYLATE ION
著者Johansson, K., El-Ahmad, M., Friemann, R., Jornvall, H., Markovic, O., Eklund, H.
登録日2001-11-20
公開日2002-04-18
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal Structure of Plant Pectin Methylesterase
FEBS Lett., 514, 2002
2PUK
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CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FERREDOXIN: THIOREDOXIN REDUCTASE AND THIOREDOXIN M
分子名称:Ferredoxin-thioredoxin reductase, catalytic chain, variable chain, ...
著者Dai, S., Friemann, R., Schurmann, P., Eklund, H.
登録日2007-05-09
公開日2007-07-10
最終更新日2013-09-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase.
Nature, 448, 2007
2XKN
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI-EGFR ANTIBODY 7A7
分子名称:ANTI-EGFR ANTIBODY 7A7, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
著者Talavera, A., Mackenzie, J., Friemann, R., Krengel, U.
登録日2010-07-09
公開日2011-06-15
最終更新日2011-08-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of the Fab Fragment of the Anti-Murine Egfr Antibody 7A7 and Exploration of its Receptor Binding Site.
Mol.Immunol., 48, 2011
3GKW
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF NIMOTUZUMAB. AN ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY
分子名称:Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, DI(HYDROXYETHYL)ETHER, ...
著者Talavera, A., Friemann, R., Martinez-Fleites, C., Moreno, E., Krengel, U.
登録日2009-03-11
公開日2009-08-04
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation
Cancer Res., 69, 2009
3NZ8
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CRYSTAL STRUCTURE OF THE HIV-2 NEUTRALIZING FAB FRAGMENT 7C8
分子名称:Mouse anti V3 antibody 7C8 Fab, heavy chain, light chain, ...
著者Uchtenhagen, H., Friemann, R., Raszewski, G., Spetz, A.-L., Nilsson, L., Achour, A.
登録日2010-07-16
公開日2011-05-18
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of the HIV-2 Neutralizing Fab Fragment 7C8 with High Specificity to the V3 Region of gp125.
Plos One, 6, 2011
3QUK
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CRYSTAL STRUCTURES OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH LCMV-DERIVED GP33 ALTERED PEPTIDE LIGAND (Y4A)
分子名称:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
著者Allerbring, E., Duru, A.D., Uchtenhagen, H., Madhurantakam, C., Grimm, S., Tomek, M.B., Mazumdar, P.A., Spetz, A., Friemann, R., Sandalova, T., Uhlin, M., Nygren, P., Achour, A.
登録日2011-02-24
公開日2012-03-21
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.
Eur.J.Immunol., 42, 2012
3QUL
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CRYSTAL STRUCTURES OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH LCMV-DERIVED GP33 ALTERED PEPTIDE LIGAND (Y4S)
分子名称:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
著者Allerbring, E., Duru, A.D., Uchtenhagen, H., Madhurantakam, C., Grimm, S., Tomek, M.B., Mazumdar, P.A., Spetz, A., Friemann, R., Sandalova, T., Uhlin, M., Nygren, P., Achour, A.
登録日2011-02-24
公開日2012-03-21
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.
Eur.J.Immunol., 42, 2012
5KZD
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N-ACETYLNEURAMINATE LYASE FROM METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS WITH BOUND SIALIC ACID ALDITOL
分子名称:N-acetylneuraminate lyase, (2~{S},4~{S},5~{R},6~{R},7~{S},8~{R})-5-acetamido-2,4,6,7,8,9-hexakis(oxidanyl)nonanoic acid
著者North, R.A., Watson, A.J.A., Pearce, F.G., Muscroft-Taylor, A.C., Friemann, R., Fairbanks, A.J., Dobson, R.C.J.
登録日2016-07-25
公開日2017-01-11
実験手法X-RAY DIFFRACTION (2.334 Å)
主引用文献Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.
FEBS Lett., 590, 2016
5KZE
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N-ACETYLNEURAMINATE LYASE FROM METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
分子名称:N-acetylneuraminate lyase, SULFATE ION, GLYCEROL
著者North, R.A., Watson, A.J.A., Pearce, F.G., Muscroft-Taylor, A.C., Friemann, R., Fairbanks, A.J., Dobson, R.C.J.
登録日2016-07-25
公開日2017-01-11
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.
FEBS Lett., 590, 2016
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