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3HVT
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STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Steitz, T.A., Smerdon, S.J., Jaeger, J., Wang, J., Kohlstaedt, L.A., Chirino, A.J., Friedman, J.M., Rice, P.A.
Deposit date:1994-07-25
Release date:1994-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
Proc.Natl.Acad.Sci.Usa, 91, 1994
1KFD
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CRYSTAL STRUCTURES OF THE KLENOW FRAGMENT OF DNA POLYMERASE I COMPLEXED WITH DEOXYNUCLEOSIDE TRIPHOSPHATE AND PYROPHOSPHATE
Descriptor:DNA POLYMERASE I KLENOW FRAGMENT, CYTIDINE-5'-TRIPHOSPHATE
Authors:Beese, L.S., Friedman, J.M., Steitz, T.A.
Deposit date:1993-09-23
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate.
Biochemistry, 32, 1993
1XYE
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T-TO-THIGH TRANSITIONS IN HUMAN HEMOGLOBIN: ALPHA Y42A DEOXY LOW SALT
Descriptor:Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
Authors:Kavanaugh, J.S., Rogers, P.H., Arnone, A., Hui, H.L., Wierzba, A., DeYoung, A., Kwiatkowski, L.D., Noble, R.W., Juszczak, L.J., Peterson, E.S., Friedman, J.M.
Deposit date:2004-11-09
Release date:2004-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Intersubunit interactions associated with tyr42alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin
Biochemistry, 44, 2005
1XZ2
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WILD-TYPE HEMOGLOBIN DEOXY NO-SALT
Descriptor:Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
Authors:Kavanaugh, J.S., Rogers, P.H., Arnone, A., Hui, H.L., Wierzba, A., DeYoung, A., Kwiatkowski, L.D., Noble, R.W., Juszczak, L.J., Peterson, E.S., Friedman, J.M.
Deposit date:2004-11-11
Release date:2004-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Intersubunit interactions associated with tyr42alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin
Biochemistry, 44, 2005
1XZ4
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INTERSUBUNIT INTERACTIONS ASSOCIATED WITH TYR42ALPHA STABILIZE THE QUATERNARY-T TETRAMER BUT ARE NOT MAJOR QUATERNARY CONSTRAINTS IN DEOXYHEMOGLOBIN: ALPHAY42A DEOXYHEMOGLOBIN NO-SALT
Descriptor:Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
Authors:Kavanaugh, J.S., Rogers, P.H., Arnone, A., Hui, H.L., Wierzba, A., DeYoung, A., Kwiatkowski, L.D., Noble, R.W., Juszczak, L.J., Peterson, E.S., Friedman, J.M.
Deposit date:2004-11-11
Release date:2004-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Intersubunit interactions associated with tyr42alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin
Biochemistry, 44, 2005
1G7U
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CRYSTAL STRUCTURES OF KDO8P SYNTHASE IN ITS BINARY COMPLEX WITH SUBSTRATE PHOSPHOENOL PYRUVATE
Descriptor:2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE, PHOSPHOENOLPYRUVATE
Authors:Asojo, O.A., Friedman, J.M., Belakhov, V., Shoham, Y., Adir, N., Baasov, T.
Deposit date:2000-11-14
Release date:2001-05-16
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor.
Biochemistry, 40, 2001
1G7V
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CRYSTAL STRUCTURES OF KDO8P SYNTHASE IN ITS BINARY COMPLEXES WITH THE MECHANISM-BASED INHIBITOR
Descriptor:2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE, {[(2,2-DIHYDROXY-ETHYL)-(2,3,4,5-TETRAHYDROXY-6-PHOSPHONOOXY-HEXYL)-AMINO]-METHYL}-PHOSPHONIC ACID
Authors:Asojo, O.A., Friedman, J.M., Belakhov, V., Shoham, Y., Adir, N., Baasov, T.
Deposit date:2000-11-14
Release date:2001-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor.
Biochemistry, 40, 2001
1AX8
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HUMAN OBESITY PROTEIN, LEPTIN
Descriptor:OBESITY PROTEIN
Authors:Zhang, F., Beals, J.M., Briggs, S.L., Clawson, D.K., Wery, J.-P., Schevitz, R.W.
Deposit date:1997-10-31
Release date:1998-11-25
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the obese protein leptin-E100.
Nature, 387, 1997
1TV6
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH CP-94,707
Descriptor:reverse transcriptase p66 subunit, reverse transcriptase p51 subunit, 3-[4-(2-METHYL-IMIDAZO[4,5-C]PYRIDIN-1-YL)BENZYL]-3H-BENZOTHIAZOL-2-ONE
Authors:Pata, J.D., Stirtan, W.G., Goldstein, S.W., Steitz, T.A.
Deposit date:2004-06-28
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant RTs resistant to other non-nucleoside inhibitors
Proc.Natl.Acad.Sci.USA, 101, 2004
1KLN
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DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(*GP*CP*CP*TP*CP*GP*CP*GP*GP*CP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*GP*CP*GP*AP*GP*GP*C)-3'), PROTEIN (DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7)), ...
Authors:Beese, L.S., Derbyshire, V., Steitz, T.A.
Deposit date:1994-05-24
Release date:1994-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of DNA polymerase I Klenow fragment bound to duplex DNA.
Science, 260, 1993
4HBI
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SCAPHARCA DIMERIC HEMOGLOBIN, MUTANT T72I, DEOXY FORM
Descriptor:HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Royer Junior, W.E.
Deposit date:1998-06-24
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: structural basis for altered allosteric activity.
J.Mol.Biol., 284, 1998
5HBI
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SCAPHARCA DIMERIC HEMOGLOBIN, MUTANT T72I, CO-LIGANDED FORM
Descriptor:HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Royer Junior, W.E.
Deposit date:1998-06-24
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: structural basis for altered allosteric activity.
J.Mol.Biol., 284, 1998
6HBI
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SCAPHARCA DIMERIC HEMOGLOBIN, MUTANT T72V, DEOXY FORM
Descriptor:HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Royer Junior, W.E.
Deposit date:1998-06-25
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: structural basis for altered allosteric activity.
J.Mol.Biol., 284, 1998
7HBI
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SCAPHARCA DIMERIC HEMOGLOBIN, MUTANT T72V, CO-LIGANDED FORM
Descriptor:HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Royer Junior, W.E.
Deposit date:1998-06-25
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: structural basis for altered allosteric activity.
J.Mol.Biol., 284, 1998