Author results

3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
5FO4
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CRYSTAL STRUCTURE OF THE P.FALCIPARUM CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (SPACE GROUP P1)
分子名称:LEUCYL TRNA SYNTHASE
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-18
公開日2016-06-22
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOC
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CRYSTAL STRUCTURE OF THE P.FALCIPARUM CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (SPACE GROUP P21)
分子名称:LEUCYL-TRNA SYNTHETASE
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-19
公開日2016-06-22
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOD
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CRYSTAL STRUCTURE OF THE P.FALCIPARUM CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (SPACE GROUP P1) CONTAINING DELETIONS OF INSERTIONS 1 AND 3
分子名称:LEUCYL-TRNA SYNTHETASE, 1,2-ETHANEDIOL
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-19
公開日2016-06-22
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOF
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CRYSTAL STRUCTURE OF THE P.KNOWLESI CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN
分子名称:LEUCYL-TRNA SYNTHETASE
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-19
公開日2016-06-22
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
3O0J
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PDE4B IN COMPLEX WITH LIGAND AN2898
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
著者Alley, M.R.K., Zhou, Y.
登録日2010-07-19
公開日2011-08-10
最終更新日2013-01-23
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
Febs Lett., 586, 2012
5FOG
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CRYSTAL STRUCTURE OF HTE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH A POST-TRANSFER EDITING ANALOGUE OF NORVALINE (NV2AA)
分子名称:LEUCYL-TRNA SYNTHETASE, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 1,2-ETHANEDIOL, ...
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-20
公開日2016-08-03
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOL
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH A POST-TRANSFER EDITING ANALOGUE OF ISOEUCINE (ILE2AA)
分子名称:LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION, 2'-(L-ISOLEUCYL)AMINO-2'-DEOXYADENOSINE
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOM
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH THE ADDUCT AMP-AN6426
分子名称:LEUCYL-TRNA SYNTHETASE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, PHOSPHATE ION
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FON
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (APO STRUCTURE)
分子名称:LEUCYL-TRNA SYNTHETASE
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5NNO
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STRUCTURE OF TBALDH3 COMPLEXED WITH NAD AND AN3057 ALDEHYDE
分子名称:Aldehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-[(1-oxidanyl-3~{H}-2,1-benzoxaborol-5-yl)oxy]benzaldehyde
著者Zoltner, M., Zhang, N., Horn, D., Field, M.C.
登録日2017-04-10
公開日2017-04-19
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.
PLoS Pathog., 14, 2018