Author results

2NT3
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RECEIVER DOMAIN FROM MYXOCOCCUS XANTHUS SOCIAL MOTILITY PROTEIN FRZS (Y102A MUTANT)
Descriptor:Response regulator homolog
Authors:Fraser, J.S., Echols, N., Merlie, J.P., Zusman, D.R., Alber, T.
Deposit date:2006-11-06
Release date:2007-03-13
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS.
Mol.Microbiol., 65, 2007
3K0M
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CRYOGENIC STRUCTURE OF CYPA
Descriptor:Cyclophilin A
Authors:Fraser, J.S., Alber, T.
Deposit date:2009-09-24
Release date:2009-12-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Hidden alternative structures of proline isomerase essential for catalysis.
Nature, 462, 2009
3K0N
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ROOM TEMPERATURE STRUCTURE OF CYPA
Descriptor:Cyclophilin A
Authors:Fraser, J.S., Alber, T.
Deposit date:2009-09-24
Release date:2009-12-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.391 Å)
Cite:Hidden alternative structures of proline isomerase essential for catalysis.
Nature, 462, 2009
3K0O
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ROOM TEMPERATURE STRUCTURE OF CYPA MUTANT SER99THR
Descriptor:Cyclophilin A
Authors:Fraser, J.S., Alber, T.
Deposit date:2009-09-24
Release date:2009-12-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Hidden alternative structures of proline isomerase essential for catalysis.
Nature, 462, 2009
3K0P
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CRYOGENIC STRUCTURE OF CYPA MUTANT SER99THR
Descriptor:Cyclophilin A
Authors:Fraser, J.S., Alber, T.
Deposit date:2009-09-24
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Hidden alternative structures of proline isomerase essential for catalysis.
Nature, 462, 2009
3K0Q
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CRYOGENIC STRUCTURE OF CYPA MUTANT SER99THR (2)
Descriptor:Cyclophilin A
Authors:Fraser, J.S., Alber, T.
Deposit date:2009-09-24
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.317 Å)
Cite:Hidden alternative structures of proline isomerase essential for catalysis.
Nature, 462, 2009
3K0R
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CRYOGENIC STRUCTURE OF CYPA MUTANT ARG55LYS
Descriptor:Cyclophilin A
Authors:Fraser, J.S., Alber, T.
Deposit date:2009-09-25
Release date:2009-12-08
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.424 Å)
Cite:Hidden alternative structures of proline isomerase essential for catalysis.
Nature, 462, 2009
3TGP
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ROOM TEMPERATURE H-RAS
Descriptor:GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Fraser, J.S., Alber, T.
Deposit date:2011-08-17
Release date:2011-10-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3075 Å)
Cite:Accessing protein conformational ensembles using room-temperature X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 108, 2011
4OBV
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RUMINOCOCCUS GNAVUS TRYPTOPHAN DECARBOXYLASE RUMGNA_01526 (ALPHA-FMT)
Descriptor:Pyridoxal-dependent decarboxylase domain protein, alpha-(fluoromethyl)-D-tryptophan, {5-hydroxy-4-[(1E)-4-(1H-indol-3-yl)-3-oxobut-1-en-1-yl]-6-methylpyridin-3-yl}methyl dihydrogen phosphate
Authors:Fraser, J.S., Van Benschoten, A.H.
Deposit date:2014-01-07
Release date:2014-10-29
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
Cell Host Microbe, 16, 2014
5F66
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HIGH-RESOLUTION ISOTROPIC MULTICONFORMER SYNCHROTRON MODEL OF CYPA AT 273 K
Descriptor:Peptidyl-prolyl cis-trans isomerase A
Authors:Fraser, J.S.
Deposit date:2015-12-05
Release date:2015-12-30
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Measuring and modeling diffuse scattering in protein X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 113, 2016
5WC7
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CYPA MUTANT - I97V S99T C115S
Descriptor:Peptidyl-prolyl cis-trans isomerase A
Authors:Fraser, J.S.
Deposit date:2017-06-29
Release date:2018-04-18
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Rescue of conformational dynamics in enzyme catalysis by directed evolution.
Nat Commun, 9, 2018
6BTA
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CYPA MUTANT - S99T C115S
Descriptor:Peptidyl-prolyl cis-trans isomerase A
Authors:Fraser, J.S., Kenner, L.R., Liu, L.
Deposit date:2017-12-06
Release date:2018-04-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Rescue of conformational dynamics in enzyme catalysis by directed evolution.
Nat Commun, 9, 2018
4XV4
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CCP GATELESS CAVITY
Descriptor:Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Fischer, M., Fraser, J.S.
Deposit date:2015-01-26
Release date:2015-02-18
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.
Chembiochem, 16, 2015
4XV5
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CCP GATELESS CAVITY
Descriptor:Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Fischer, M., Fraser, J.S.
Deposit date:2015-01-26
Release date:2015-02-25
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.
Chembiochem, 16, 2015
4XV6
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CCP GATELESS CAVITY
Descriptor:Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Fischer, M., Fraser, J.S.
Deposit date:2015-01-26
Release date:2015-02-18
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.
Chembiochem, 16, 2015
4XV7
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CCP GATELESS CAVITY
Descriptor:Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Fischer, M., Fraser, J.S.
Deposit date:2015-01-26
Release date:2015-02-18
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.
Chembiochem, 16, 2015
4XV8
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CCP GATELESS CAVITY
Descriptor:Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Fischer, M., Fraser, J.S.
Deposit date:2015-01-26
Release date:2015-02-18
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.
Chembiochem, 16, 2015
4XVA
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CRYSTAL STRUCTURE OF WILD TYPE CYTOCHROME C PEROXIDASE
Descriptor:Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Fischer, M., Fraser, J.S.
Deposit date:2015-01-26
Release date:2015-02-25
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.
Chembiochem, 16, 2015
6B90
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MULTICONFORMER MODEL OF APO WT PTP1B WITH GLYCEROL AT 100 K (ALTERNATIVE REFINEMENT OF PDB 1SUG SHOWING CONFORMATIONAL HETEROGENEITY)
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, GLYCEROL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2017-10-09
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
3J9J
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STRUCTURE OF THE CAPSAICIN RECEPTOR, TRPV1, DETERMINED BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY
Descriptor:Transient receptor potential cation channel subfamily V member 1
Authors:Wang, R.Y.-R., Barad, B.A., Fraser, J.S., DiMaio, F.
Deposit date:2015-02-02
Release date:2015-09-02
Last modified:2015-10-14
Method:ELECTRON MICROSCOPY (3.275 Å)
Cite:EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.
Nat.Methods, 12, 2015
4KJJ
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CRYOGENIC WT DHFR
Descriptor:Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:van den Bedem, H., Bhabha, G., Yang, K., Wright, P.E., Fraser, J.S.
Deposit date:2013-05-03
Release date:2013-08-21
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
4KJK
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ROOM TEMPERATURE WT DHFR
Descriptor:Dihydrofolate reductase, FOLIC ACID, CALCIUM ION, ...
Authors:van den Bedem, H., Bhabha, G., Yang, K., Wright, P.E., Fraser, J.S.
Deposit date:2013-05-03
Release date:2013-08-21
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.351 Å)
Cite:Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
4KJL
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ROOM TEMPERATURE N23PPS148A DHFR
Descriptor:Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:van den Bedem, H., Bhabha, G., Yang, K., Wright, P.E., Fraser, J.S.
Deposit date:2013-05-03
Release date:2013-08-21
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
4NVA
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PREDICTING PROTEIN CONFORMATIONAL RESPONSE IN PROSPECTIVE LIGAND DISCOVERY
Descriptor:Cytochrome c peroxidase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Fischer, M., Fraser, J.S.
Deposit date:2013-12-05
Release date:2013-12-18
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery.
Nat Chem, 6, 2014
4NVB
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PREDICTING PROTEIN CONFORMATIONAL RESPONSE IN PROSPECTIVE LIGAND DISCOVERY.
Descriptor:Cytochrome c peroxidase, PROTOPORPHYRIN IX CONTAINING FE, 2-AMINO-5-METHYLTHIAZOLE
Authors:Fischer, M., Fraser, J.S.
Deposit date:2013-12-05
Release date:2013-12-18
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery.
Nat Chem, 6, 2014